Strained Rings

Ru(II)-catalyzed peri-C–H activation harnesses the ring strain of alkylidene β-lactones/lactams to unlock divergent annulations—delivering rare 7- & 4-membered heterocycles with high selectivity. ⚡ @JOC_OL @MBaidyaGroup @iitmadras pubs.acs.org/doi/10.1021/ac…

🦋Double strain, double impact 💥! A dual strain-release cascade builds azetidine–bicyclopentane frameworks packed with quaternary centers—turning ring strain into powerful 3D complexity ⚡ @JOC_OL @dturesh @iiserkol pubs.acs.org/doi/10.1021/ac…

Francis Gosselin has recently joined #OrgLett as an Associate Editor. Dr. Gosselin is an industry leader with extensive experience in pharmaceutical development. He specializes in process chem, asymm. catal., flow methods, and data‑driven optimization. go.acs.org/dWF

🦋 Pd-catalyzed tandem cascade transforms highly strained bicyclobutyl amides into fused spiroquinolinones, harnessing BCB strain for rapid skeletal assembly—small rings driving big, elegant polycycle construction ⚡ @JOC_OL pubs.acs.org/doi/10.1021/ac…

The work of @josh_wwu @TobiasMilzarek and Matt on the synthesis of CF3-cycloproprenes using hypervalent iodine reagents and Cu(III) complexes is now published in Org. Lett. doi.org/10.1021/acs.or…

Happy to share our first preprint @ChemRxiv Base-Mediated (4+3) Strain-Release Cycloaddition of Indoles BCBs. Congratulations to @SayantanKundu16 @pragati_kisan Thank you, Satish and group, @cdriacademy for computational studies @IISER_BERHAMPUR | chemrxiv.org/doi/full/10.26…

Happy to share that our latest work is now published in @J_A_C_S ! 🎉 Congratulations to Noam Orbach and Rahul Suresh (@rahul_suresh9) on this achievement! 💐 pubs.acs.org/doi/10.1021/ja…

Everything about small bicycles, and their use in Medchem! With Vladimir Kubyshkin (@polyproline), we have summarized that for you in this @ACSChemRev: bit.ly/4760Vrc

💥 Small ring, big reactivity! FLP activation enables heteronuclear dual-atom insertion into strained oxetanes, forging new heterocycles via strain-release skeletal editing ⚡ @NatureSynthesis @MJKoh87 @NUSingapore doi.org/10.1038/s44160…

Six BCP-containing molecules are in clinical trials now. We might see a first BCP-containing drug real soon!

💥Flat benzene → 3D bioisosteres! 🦋 Strained bicyclobutanes power cycloadditions to thia-bicyclo[3.1.1]heptanes, delivering precise mimics of meta, ortho and 1,2,4-trisubstituted arenes for modern medicinal chemistry @NatureChemistry @Jian_Jun_Feng doi.org/10.1038/s41557…

⚡Big 3D chemistry, tiny catalyst loadings ! Enantioselective catalysis builds spirolactones & spirolactams— 🔺rigid, strain-laden spiro scaffolds forged with remarkable efficiency 💥🧪 @J_A_C_S @Huw78347000 pubs.acs.org/doi/10.1021/ja…

🦋Tiny ring, huge energy ⚡Strained azabicyclo[1.1.0]butyl carbinols undergo catalytic enantioselective N-allylation, triggering ring-opening to sculpt chiral tertiary amines—ABB strain unleashed for 3D synthesis 🧪 @angew_chem @IITKgp @SantanuPan15325 onlinelibrary.wiley.com/doi/10.1002/an…

🦋 Ir-catalyzed asymmetric functionalization of strained bicyclo[1.1.0]butane boronic esters uses ring strain to drive 1,2-oxygen migration, delivering enantioenriched cis-cyclobutanes with precision and elegance ⚡ @NatureComms doi.org/10.1038/s41467…

💥 Strained BN-benzvalene at a crossroads — catalyst-controlled rearomatization unlocks divergent BN-arene topologies, converting pent-up strain into programmable reactivity ⚡🔬 @J_A_C_S @ChemistryBC @BostonCollege pubs.acs.org/doi/10.1021/ja…

🔺Catalytic Re(I)-mediated vinylcarbene cyclopropanation delivers architecturally crisp cyclopropanes—strain sculpted with organometallic elegance ⚙️ @JOC_OL pubs.acs.org/doi/10.1021/ac…

⚡ Pd-catalyzed C–C arylation of strained azabicyclo[4.1.1]octanols unlocks multifunctional azepines—turning ring strain into diverse N-heterocycles with elegance 🧨✨ @JOC_OL pubs.acs.org/doi/10.1021/ac…

🦋 Strain unleashed! 💥 Iron-catalyzed radical 1,3-azidoalkylation of bicyclo[1.1.0]butanes harnesses ring strain to build 1,1,3,3-tetrasubstituted cyclobutanes—elegant strain-release for complex scaffolds ✨ @JOC_OL pubs.acs.org/doi/10.1021/ac…

💫 @EdAndersonGroup unveil hetero[3.1.1]propellanes — strained small-ring systems with O/N/S handles. Radical ring-opening unlocks diverse 3-hetero-BCHeps for drug design, turning strain into utility. 🧨 @NatureChemistry @UniofOxford doi.org/10.1038/s41557…

@EdAndersonGroup unveil hetero[3.1.1]propellanes — strained small-ring systems with O/N/S handles. Radical ring-opening unlocks diverse 3-hetero-BCHeps for drug design, turning strain into utility. 🧨 @NatureChemistry @UniofOxford doi.org/10.1038/s41557… doi.org/10.1038/s41557…