Strained Rings

"Strained ring preprint hat trick" at @LcsoLab with the last work of @CarloBalda97 with @IBMResearch @NCCR_Catalysis on the aminoarylation of cyclopropanes using complementary photo- and copper-catalyzed approaches now available at @ChemRxiv doi.org/10.26434/chemr…

🦋Radicals and diradicaloids harness the latent energy of strained cycloalkanes, revealing how diradical character and strain release dictate reactivity, selectivity, and molecular complexity 🧪🚀 @J_A_C_S @GargLab @houk1000 pubs.acs.org/doi/10.1021/ja…

🦋 Tunable Pd catalysis exploits vinylbicyclo[1.1.0]butanes to orchestrate divergent [2π+2σ] cycloaddition/Alder-ene pathways, forging architecturally sophisticated, strain-rich heterocycles with precision ⚡️ @JOC_OL doi.org/10.1021/acs.jo…

Triple energy transfer-enabled dearomative cycloaddition/rearrangement cascade of bicyclic azaarenes to structurally complex products dlvr.it/TTQv91

A convergent access to medium-size rigidified nitrogen heterocycles: Have a look at the last work of Stefano Nicolai and Daphne Lucidarme on the annulation of bicyclobutanes and azadienes to give azabicyclooctanes now as a preprint at @ChemRxiv chemrxiv.org/doi/full/10.26…

🦋 Enantioselective diastereodivergent coupling of aldehydes with highly strained bicyclo[1.1.0]butanes unlocks precise access to architecturally complex cyclobutanes with exceptional chemo- and stereoselectivity 🚀 @OrgChemFront doi.org/10.1039/D6QO00…

C═C/N═O metathesis enables oxidative decarboxylation, rapidly forming strain-rich molecular intermediate via elegant bond reorganization and expanding the horizons of modern synthetic chemistry ✨ @J_A_C_S @morandilab doi.org/10.1021/jacs.6…

🦋⃤ Cyclopropene–allene metathesis exploits the exceptional reactivity of strained cyclopropenes to forge axially chiral skipped ene–allenes bearing quaternary stereocenters with remarkable diastereocontrol ⚡️ @angew_chem onlinelibrary.wiley.com/doi/10.1002/an…

🦋 Harnessing ring strain with elegance ⚡️: Stereoselective Lewis acid-catalyzed chloroamidation transforms BCBs into architecturally complex 2-oxa-4-azabicyclo[3.1.1]hept-3-enes, expanding access to valuable 3D heterocyclic space 🚀 @JOC_OL doi.org/10.1021/acs.or…

Enantiospecific Homo-Boron-Wittig Reaction: Direct Conversion of Chiral Epoxides to Cyclopropanes | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Iron-Catalyzed Synthesis of Conformationally Restricted Bicyclic N-Heterocycles via [2+2]-Cycloaddition: Exploring Ring Expansion─Mechanistic Insights and Challenges pubs.acs.org/doi/10.1021/ac…

𖣘 arnesses the extraordinary reactivity of highly strained [1.1.1]propellane, enabling alkylalkynylation under photocatalyst- and ligand-free conditions to rapidly access versatile BCP architectures @JOC_OL doi.org/10.1021/acs.or…

𖣘 Light unlocks strain ✨: Photocatalytic activation of bench-stable saccharides enables direct access to C-glycosyl bicyclo[1.1.1]pentanes, transforming highly strained Propellane into sophisticated glycomimetic architectures @JOC_OL @DellAmico_group doi.org/10.1021/acs.or…

🦋Harnessing ring strain with photons ✨: A visible-light photocatalytic, phosphine-mediated strategy merges bicyclo[1.1.0]butane activation with in situ Wittig olefination, rapidly generating architecturally complex cyclobutane derivatives @JOC_OL doi.org/10.1021/acs.or…

𖣘 Transforming strain into complexity : Multicomponent dicarbofunctionalization of [1.1.1]propellane enables rapid assembly of BCP–aryl scaffolds, converting a highly strained cage into richly functionalized 3D molecular architectures ⚡️ @JOC_OL doi.org/10.1021/acs.or…

🟨 ✨ Ti catalysis transforms silacyclobutanes into versatile functionalized hydrosilanes through selective C(sp³)–Si bond hydroboration and hydrogenation—turning strained frameworks into synthetic opportunity @NatureComms doi.org/10.1038/s41467…

Harnessing the power of light✨, EnT catalysis enables a dearomative (5+4) cycloaddition between furans and oxazoles, constructing strain-rich medium-sized bridged heterocycles and expanding access to valuable 3D chemical space @J_A_C_S @GloriusGroup doi.org/10.1021/jacs.6…

Strain-release ingenuity: Harnessing the exceptional reactivity of bicyclo[1.1.0]butanes, a base-mediated (3+3) annulation delivers architecturally intricate 3-azabicyclo[3.1.1]heptanes, expanding the frontier of 3D scaffold synthesis @JOC_OL @ATBijuLab doi.org/10.1021/acs.or…

🦋Strain illuminated by light ✨⚡️: Organophotocatalytic hydrosilylation harnesses the latent energy of highly strained BCBs, enabling efficient C–Si bond construction and rapid access to architecturally sophisticated cyclobutanes @JOC_OL doi.org/10.1021/acs.or…

Very happy to introduce BCB-Bx as an electrophilic bicyclobutane synthon! Have a look at the preprint at @ChemRxiv A great teamwork of @najung_lee_ @josh_wwu Philipp Schoch, @DuncanBrownsey @JozefKristek1 and Matt Wodrich. chemrxiv.org/doi/full/10.26…