Subhi Marwari

NeuraClick Welcomes Biotech Veteran Daniel M. Bradbury as Strategic and Metabolic Programs Advisor globenewswire.com/news-release/2…

career advice: the fastest route is not always a straight line.

It's better to be the wisest person in the room than the smartest. People prove their intelligence by showing what they know. They reveal their wisdom by integrating what everyone knows. Intelligence can be used to advance personal agendas. Wisdom guides groups to shared goals.

New paper alert @BrJPharmacol! Exploring pharmacological inhibition of Gq/11 as an analgesic strategy doi.org/10.1111/bph.15… Using mouse models of acute pain, the present study demonstrated the analgesic properties of YM (Gq inhibitor) treatment and its synergy with opioids

So happy and excited to finally see this paper coming! Many thanks @KLabGPCR for amazing ideas, great science, and outstanding mentorship. Congrats @CodyKowalski -wonderful collaboration.

A gem for those who still debate academia “versus” industry. The present reality is that all in industry were once in academia, as trainees or scholars, and many in industry will return to teach, advise, investigate. The era of the One Way ticket is firmly over, buy the bus pass!

Please, join me in raising funds for bringing life-transforming, innovative therapies, rare disease awareness, and patient advocacy for our little warriors. @cureSYNGAP1 @Syngap1Fnd @SyngapNetwork @JMGraglia secure.givelively.org//donate/syngap…

Three proteins found that help fine tune movement sciencedaily.com/releases/2022/…

Our latest on new elements controlling #GPCR signaling to #cAMP. CRISPR screen in striatal neurons identified major role of KCTD5 in the process. It controls Gbetagamma inputs to cyclase and unexpectedly also its modulation by zinc! pnas.org/content/119/1/…

सफल होने के लिए परिवार और दोस्तों की ज़रूरत होती है. पर महान बनने के लिए दुश्मनों और आपको चुनौती देने वालों की ज़रूरत होती है.

Can a #GPCR structure still surprise you? Happy to present #CryoEM structure of an orphan receptor GPR158. science.org/doi/10.1126/sc… Couples to RGS instead of G proteins. Features an extracellular Cache domain for ligand binding Forms a unique tight dimer stapled by phospholipids

G protein Go couples to virtually all #GPCRs. It is one of the most abundant proteins in the brain and mutations in it cause #GNAO1 disorder. Here we describe how it regulates neuromodulatory signaling in the striatum. @gnao1research cell.com/cell-reports/f…

The Mental Life of Plants and Worms, Among Others nybooks.com/articles/2014/… via @nybooks

Erwin Schrödinger published his famous thought experiment, Schrödinger's cat #OTD in 1935. It illustrates the problem of the Copenhagen interpretation of quantum mechanics. In 1933 Schrödinger was awarded the #NobelPrize in Physics.

Intranasal administration of a stapled relaxin-3 mimetic has anxiolytic- and antidepressant-like activity in rats. dlvr.it/RhFc0j

Such an inspirational and interesting drug development strategy insights! ted.com/talks/jay_brad… via @TEDTalks @jaybradner

Take a look at how #remdesivir and other inhibitors interact with SARS-CoV-2 RNA polymerase (RdRp).  youtu.be/5a8FrFRqZqM

Denali Therapeutics unveils blood-brain barrier delivery system cen.acs.org/content/cen/ar… via @cenmag

The pangolin #coronavirus was highly similar to #SARSCoV2 in several key proteins, including a remarkably similar spike protein RBD that differs from the SARS-CoV-2 RBD at only ONE amino acid position out of ~457 amino acids. (3/5)

A key piece of the #COVID19 #SARSCoV2 origin puzzle emerges: where did the virus's unusual spike protein RBD—the receptor-binding domain that engages human ACE2 protein and allows the virus to enter human cells—come from? A new study from Shen & coworkers provides an answer.(1/5)