Karsten Eastman

@yamanakanobody DBZ, JJK and One Piece are more popular

海外で1番流行った日本のアニメはナルトで良いんだよね！

@Dongurihou FF7

親愛なるアメリカのフォロワー様たちへ このポストが見えているのなら、 好きな日本のテレビゲームを教えてほしいです！ ちょっと知ってみたい……

What if we could make next-gen peptide drugs (think supercharged Ozempic) more stable, longer-lasting, and able to hit "undruggable" diseases? 💊💉⚗️ A radical enzyme called PapB just unlocked that - one enzymatic step to staple peptides into durable rings. Interview w/ discoverer Dr. Karsten Eastman @Taikade - CEO @SetheraTx drops today! 🔥 Watch: youtube.com/watch?v=ZnRRFK… #PeptideTherapeutics #Biotech #GLP1 #DrugDiscovery @JVPR_NY

What if we could make next-gen peptide drugs (think supercharged Ozempic) more stable, longer-lasting, and able to hit "undruggable" diseases? 💊💉⚗️ A radical enzyme called PapB just unlocked that - one enzymatic step to staple peptides into durable rings. Interview w/ discoverer Dr. Karsten Eastman @Taikade - CEO @SetheraTx drops today! 🔥 #PeptideTherapeutics #Biotech #GLP1 #DrugDiscovery @JVPR_NY

Enzymes as design tools, not just catalysts. This interview covers how we harness rSAM chemistry to create recombinant polymacrocyclic peptides with drug-like properties. drugdiscoveryonline.com/doc/how-sether… #Peptides #DrugDiscovery #Enzymology

Enzyme PapB could boost diabetes and obesity peptide drugs drugtargetreview.com/news/189749/en…

Check out our recent publication on enzymatic modification of GLP1 analogs! We think this is really exciting because it opens many unique doors for architectural changes in late-stage peptide development. pubs.acs.org/doi/10.1021/ac…

Sethera's first paper has released at PNAS. Check it out here! pnas.org/doi/10.1073/pn… #peptides #enzymes #science

@Vahooster and I were interviewed about the unusual enzyme that we have been working with. Check it out here: bioxconomy.com/modalities/pap…

Natural enzyme expands possibilities for peptide drug discovery phys.org/news/2025-08-n… via @physorg_com

@MinteerLab Thank you!

Nice work, Karsten!!!!

A promiscuous #rSAM enzyme enables diverse peptide cross-linking doi.org/10.1021/acsbio… Working together with @taikade @MCMChem Paul Oblad, and @Vahooster (Bandarian) we show that PapB has a high tolerance for variations in the peptide substrate. @UtahChemistry @UUtah

New in JBC press: "Scientists' findings lead to a new paradigm involving intermolecular electron transfer steps in the activation of rSAM enzymes that require multiple iron-sulfur clusters for turnover." Learn more: jbc.org/article/S0021-…

@ACSBioMed @Vahooster @UtahChemistry Very glad to see this out!

A Promiscuous #rSAM Enzyme Enables Diverse Peptide Crosslinking By Vahe Bandarian @Vahooster @UtahChemistry  🔓 Open access in ACS Bio & Med Chem Au 👉 go.acs.org/5RN #ACSBioMedChemAu

Another publication from my son, Karsten @Taikade, and others at @jbiolchem. Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation. jbc.org/article/S0021-…

Paper #3 is out! We were able to build and generate evidence for a new model for reductive activation in rSAM enzymes. We really hope other labs try the FMN + NADPH experiments! jbc.org/article/S0021-…

Starting to understand how a radical SAM enzyme makes a thioether crosslink - the auxiliary iron-sulfur cluster binds the substrate! pubs.acs.org/doi/10.1021/ja…

Peptide Selenocysteine Substitutions Reveal Direct Substrate–Enzyme Interactions at Auxiliary Clusters in Radical S-Adenosyl-l-methionine Maturases @OHSUNews @UtahChemistry @Vahooster @UUtah #Peptide #Selenocysteine #Clusters #Radical #SAM #Maturases pubs.acs.org/doi/10.1021/ja…

@J_A_C_S @OHSUNews @UtahChemistry @Vahooster @UUtah I am so glad this work is finally out!