aadi

@xtinacomputes 🔥

my march madness bracket is rank 71 out of 26,600,000 holy

Im so fucking excited about people finding out about orexin's role in other conditions like ADHD because so long as it was relegated to an issue for a rare disease (narcolepsy) that conveniently makes its sufferers pretty unemployable, and thus theres no financial incentive to cure it, we were kinda fucked

ah what the hell the anti-adhd peptide thing is REAL. they might have found the causal driver for 'adhd', and it's basically entirely sleep-wake-cycle stuff (???) which explains a lot tbh

@tucciarone2026 conservatives canNOT have fun

I used to WORK for TPUSA TPUSA Faith exists to equip Christians to live out biblical truth, fight cultural degeneracy, and be salt and light. But at AmFest 2024's after-party (hosted by James O'Keefe – the 'Make America Rave Again' blowout), this is what went down: a half-naked woman in a giant wine glass full of water, grinding sexually, splashing the crowd while booze flows everywhere – and she wraps our American flag around her like a cape. Straight-up Flag Code disrespect and total cultural compromise. This is the 'party of the decade' our youth are funneled into? Where's the biblical modesty? The respect for sacred symbols? The consistency on fighting degeneracy? Former insider here – this doesn't align with what TPUSA preaches. Video is real, unedited, from the event I was at. Judge for yourself. Thoughts, @TPUSA

@PseudoAeschines @HellenicVibes @lgngrvs @realityarb If Stanford undergrads aren’t having fun it’s because they haven’t met me yet

@HellenicVibes @lgngrvs @realityarb @techbrahh this true?

Hearing a lot of reports that Stanford undergrads are now antisocial and kinda depressive… is this true?? Back when I used to visit Stanford seemed like paradise, frat parties were awesome, everyone was tan & happy.

Imagine you were a class clown who kept getting yelled at by all the adults in your life about needing to grow up, so you finally take the meds and kill your inner child and learn to code Then all those same adults build a trillion dollar supercomputer that codes better than you and takes your job, and the only profitable role left in the economy is 'streaming'

@alexkesin Based cell

Broke: Gene therapy with viral vectors Woke: CRISPR gene editing Bespoke: One random cell waking up and choosing to simply not have a genetic disease anymore

HAMILTON SOCIETY TONIGHT Remember: if you want to speak you have to come ONE HOUR early to audition. If you are bad we will say NO. ALSO: bring your government ID. Nobody gets in without one. LINK IN THE REPLIES BECAUSE IDK IF NIKITA STILL DEBOOSTS TWEETS WITH LINKS

This meme was originally meant as pejorative satire and ended up describing uncomfortable reality.

this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get

It's genuinely insane how much progress biotech has made in the last 90 days: - Two years ago I watched Lucy Therapeutics shut down after 7 years and $42M from Bill Gates, never reached human trials. Last month DeSci crowdfunded €2.5M in 72 hours for Dr Barbacid cancer trials and went straight to human trials. Zero VCs and zero committees in the middle. And it's not even about the money. The goodwill - Gene therapy cost $2-4M per treatment a year ago because manufacturing was artisanal and nobody was actually solving it. Now automation's dropping costs toward $200. Turns out it was an engineering problem all along. - Just a year ago, the FDA wouldn't touch longevity. In January 2026, first FDA-approved human trial reversing cellular age launched (ER-100). We're testing age reversal in humans right now. Not mice. - Psychedelics stuck in regulatory hell for 50 years. In February 2026, Compass crushed Phase III for psilocybin in treatment-resistant depression. - In 2023, AI drug discovery was hype. $17B got invested, zero approved drugs. Early 2026, Ginkgo x OpenAI ran over 200k autonomous experiments, 36K of those were unique. Protein costs dropped by 40% and they're already shipping commercially. Discovery timelines collapsed. - Just last year, FDA required full GMP pre-Phase 2, moved at 1950s speed. This quarter,we're fast-tracking frontier therapies, relaxing requirements, launching pilots. Something shifted and the regulatory wall is cracking. - In 2024, clinical trials had to run in US at 2x cost, half the speed. Right now in Singapore and China running trials 50% cheaper, 2x faster. Companies routing around FDA entirely. The US model is optional. I could keep going on with these, but you realize that the bottleneck was never the science. It was funding models, regulatory speed, manufacturing, geography etc And most of them are breaking since last October. Biotech has shed 30 years of broken infrastructure in 5 months and I can't be more bullish. bio/acc.

please bro just join a healthtech startup, cmon bro. 150M people with chronic illness and no real solutions bro. what if we actually made a difference bro.

I am so glad I grew up in the era of Xanax and Mango Juul pods. I am absolutely NOT hitting the THC-A LSD-25 Granny Apple Express

The Hamilton Society is pleased to announce our next debate: Resolved, that Californians Should Vote Against the Billionaire Tax. Moved by Trae Stephens (@traestephens), opposed by Brian Galle (@BDGesq). Dress code strictly formal: suit and tie for men, equivalent for ladies. Chatham House Rule. Next Saturday, 3/14, 6:30pm. Registration is mandatory. Link below.

To put things in perspective, Biden’s FDA was trying to ban otc NAC (Amazon had even stopped selling it), Curcumin, and many other supplements. We’ve come a long way.

Meet BioMedLM: a specialized language model trained on PubMed's vast biomedical literature. It's like having a medical researcher in your pocket, fine-tuned to understand complex scientific language and concepts.

@livgorton if its big enough of a lecture u can lwk just walk in

I'd go back to college just to LARP as a mech interp student. This sounds so delightful. Can one sneak in to such a class?

@danielgothits patriot

I have openclaw sending lowball offers on Zillow all day just to make boomers start panicking lol

me happily getting played by a white girl who isn't interested in me