TEXIMMED2- Freiburg Labs

@druppygill @Uniklinik_Fr @blizard_inst @BartsHepatology Thanks @druppygill for coming and sharing your expertise.

Huge thanks Tobias Böttler & all @teximmed2 for the invitation to @Uniklinik_Fr as external speaker. Big honour and great hospitality. Brilliant to talk science & all things #HBV #HDV #Tcells #NKcells. Looking forward to some new collaborations! @blizard_inst @BartsHepatology

Exhaustion of CD39-Expressing CD8+ T Cells in #Crohn’s Disease Is Linked to Clinical Outcome ow.ly/ka4y50LfZPZ

7/7: However, Omicron-breakthrough infections induced superior antibody neutralization against Omicron compared to 4th vaccination.

We are very happy to share our latest data on SARS-CoV-2 boost vaccinations & breakthrough infections in @NatureComms - great collaboration with the @MartinSchwemmle Lab! nature.com/articles/s4146… Key points: (1/7)

6/7: Breakthrough infections (after 3rd vaccination) also induced a short-lived CD8+ T cell effector response, which was compareable in phenotype and dynamics to a 4th vaccination.

5/7: Importantly, this memory pool was already formed after the 2nd vaccine dose and shows limited phenotypic changes after boosting, regardless whether specific memory subsets (TSCM & TCM) or more comprehensive measures to define memory cells (CD127+ & BCL-2) were analyzed.

4/7: Further analysis revealed the presence of classical memory cells throughout the effector phase upon boost vaccination, suggesting effector responses are built on top of a stable memory pool.

3/7: Phenotypically, the effector responses induced after each vaccination are indistinctive. Importantly, CD8 T cells with high BCL-2 expression were maintained upon boost vaccination.

2/7: Spike-specific CD8+ T cells are efficiently activated (CD38+, Ki67+, T-bet high) and expanded by a 3rd mRNA vaccination. This boosting effect lasts approx. 2 months.

Very happy to see this out in @NatureComms! 🥳🎉 We identify a distinct Tc17 cell population in Crohn’s disease with proinflammatory features linked to disease activity. Check out the paper here: nature.com/articles/s4146… Huge thank you to everyone involved @teximmed2

Excited to share our work on T cell exhaustion in Crohn’s disease. @AGA_Gastro @AnnaGlobig @Therealbbengsch CD39+ CD8 T cells in the blood are associated with Crohn's activity ⬆️T cell exhaustion 🟰 Crohn's disease activity⬇️ full paper here: gastrojournal.org/article/S0016-…

Next week, he will pass on his knowledge to the next generation at the @EASLedu School in Freiburg. easl.eu/event/decompen…

Robert Thimme giving the laudatory speech for Martin Rössle who is receiving the @EASLnews Innovation award in hepatology. A true giant in field and the godfather of TIPS. #ILC2022

#liverimmunology high profile session at the #ILC2022 and filled with experts in the audience. Great fun!

Very much enjoyed the @TRR179_2 viral #hepatitis conference in @Freiburg. Fantastic presentations by @jschoggins @EJohnWherry @EranElinav @jbaileylab @julie_lucifora @alexandrovteam @MartinSchwemmle @luglilab @teximmed2 and many others. Thanks Robert for your great hospitality!

@TheBinderLab @fireskyer @JohannHolzmann @fitterhappierAJ @bertoletti_lab Sicher valide Hypothese, die weiter untersucht gehört. @bertoletti_lab ist exzellent. Sehr gute Arbeiten zur Epitop-Diversität und Immundominanz von SARS-CoV-2 spezifischen T-Zellen auch von @profshanecrotty und @SetteLab vom LJI in San Diego.

@fireskyer @JohannHolzmann @fitterhappierAJ Einfach mal in Google oder Twitter nach T cells SARSCoV2 oder COVID suchen- da gibt’s ja viel zu. Auch immer gut: Reviewartikel zum Thema! Exzellente T-Zell-Immunologen zb in Freiburg: @teximmed2! Tobias, Maike, habt ihr noch Follow-Tips? Mir fällt noch @bertoletti_lab ein.

Hepatitis in Kinder - Superantigen mediated disease? Was zum Geier ist ein Superantigen? Damit der spezifische Teil des Immunsystems in Gang gesetzt wird, muss der Fremdling (Antigen) zuerstmal naiven T Zellen präsentiert werden. 1/

@druppygill @BritSocGastro @DrPKennedy @Peppa_Group @maini_lab @bertoletti_lab @pallett_lab @blizard_inst @BartsHepatology Congrats Uppy!

Thrilled to receive the prestigious Sir Francis Avery Jones award! Thanks @BritSocGastro & all my mentors/collaborators; @DrPKennedy @Peppa_Group @maini_lab @bertoletti_lab @pallett_lab @blizard_inst @BartsHepatology. Looking forward to giving my lecture in the plenary #HBVcure

This is going to be really good! Make sure you do not miss #ILC2022 in London. It's been a loooong time!

Once again, congrats Maike Hofmann. This prestigious research award is so very well deserved! 👏 @TRR179_2

@joostphdrenth Thanks all and congrats! Important study for self-monitoring of diet mistakes. Positive tests in placebo arm due to diet mistakes or specificity of the assay?

We did a #RCT in #celiac disease ✅We used a urine self-test to detect gluten-immunogenic-peptides (GIP) in celiac disease 📍Commercial #iVYCHECK-GIP-Urine rapid lateral flow test bit.ly/3vQADWc