Gabriele Cerutti

32 posts

Gabriele Cerutti

@theGABcerutti

Postdoctoral Research Scientist @ZuckermanBrain, Columbia University. Biochemistry/Biophysics/Structural Biology 🔬

New York, NY Katılım Şubat 2019

71 Takip Edilen68 Takipçiler

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Gabriele Cerutti@theGABcerutti·7 Kas

(1/6) Excited to share my latest paper published in @MolecularCell ! Combining structural and developmental biology @ZuckermanBrain we investigated the function of the sevenless receptor tyrosine kinase. authors.elsevier.com/c/1k3563vVUPRn…

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Molecular Cell@MolecularCell·5 Ara

Structures and pH-dependent dimerization of the sevenless receptor tyrosine kinase dlvr.it/TGchvC

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Gabriele Cerutti@theGABcerutti·7 Kas

(6/6) Big thank you to my mentor @lawrenceshapiro @ColumbiaBiochem, Andrew Tomlinson @ColumbiaGenDev, @NatEyeInstitute @SEMC_NYSBC @Frances84469032 @BobGrassucci @zhang_zhening for your support!

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Gabriele Cerutti@theGABcerutti·7 Kas

(5/6) Sevenless belongs to the ROS family of RTKs, which includes the human ROS1 involved in tissue development and non-small cell lung #cancer.

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Gabriele Cerutti@theGABcerutti·7 Kas

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Francesca Vallese@Frances84469032·3 Eki

Today I celebrate my first month as Assistant Professor at @asrc_gc . I am not great at making announcements, but I am incredibly grateful for this opportunity and to @OliBClarke for his mentorship that helped me get here. The Vallese Lab is opening its doors! Be prepared 💥

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Gabriele Cerutti@theGABcerutti·7 Haz

Such an honor to present my latest research at the 4th NYC area Cryo-EM meeting! ✨ A great collaboration between @lawrenceshapiro🔬 and Andrew Tomlinson 🪰 at @ZuckermanBrain Thanks to the organizers @RieNygaard and @OliBClarke for a fully immersive day in #cryoEM!

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Fitzpatrick Laboratory@FitzpatrickLab·6 Şub

Excited to share the structural basis of pH-activated #endocytosis by LRP2 using #cryoem now online @CellCellPress: tinyurl.com/mud8856c Great collaboration with Andrew Beenken @theGABcerutti Jonathan Barasch @ColumbiaKidney @lawrenceshapiro @ZuckermanBrain @ColumbiaBiochem

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Fitzpatrick Laboratory@FitzpatrickLab·13 Oca

Exciting times in quad 4C @ZuckermanBrain @ColumbiaBiochem!

Biochemistry & Molecular Biophysics@ColumbiaBiochem

Full Professor @Columbiabiochemistry Dr. Larry Shapiro working at his latest protein prep; photo courtesy of his partner in crime Prof. Anthony Fitzpatrick @Fitzpatricklab; something good is cooking! They are hiring, join them for exciting science!

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Francesca Vallese@Frances84469032·11 Şub

You were waiting for me ankyrin-1 complex 🤩

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Gabriele Cerutti@theGABcerutti·29 Ara

@AaronOwji Thanks! That is a possibility but I think the 1-RBD up is just very mobile as we see in 3DVA. Not sure why the preferred orientation though, we haven't seen it with other ligand-free SARS-CoV-2 spikes.

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Aaron Owji@AaronOwji·24 Ara

@theGABcerutti Great work! 1-RBD up conformation has preferred orientation in your work and Gobeil et al. Any idea whether this region is adsorbing to the AWI and locally denaturing?

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Gabriele Cerutti@theGABcerutti·24 Ara

Check out our biorxiv preprint on the #cryoem #structure of SARS-CoV-2 #omicron spike! Our analysis reveals conformational changes by mutations, providing insights into omicron’s extraordinary (and scary) antibody resistance. #COVID19 biorxiv.org/content/10.110…

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Gabriele Cerutti@theGABcerutti·8 Kas

Paper out @CellReports! We report the #CryoEM structure of a fascinating antibody that binds to a hydrophobic pocket in #SARSCoV2 spike NTD away from the NTD supersite. The structure explains tolerance to some variants of concern.

Cell Reports@CellReports

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain dlvr.it/SBz300

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The Nobel Prize@NobelPrize·5 Eki

Giorgio Parisi, @giorgioparisi – awarded this year’s #NobelPrize in Physics – was born in 1948 in Rome, Italy. He is a professor at Sapienza University of Rome, @SapienzaRoma, Italy. web.uniroma1.it/sssas/sssas/pe…

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Structure@Structure_CP·1 Tem

Check out the article by @theGABcerutti and colleagues from Lawrence Shapiro lab at @Columbia reporting #cryoEM #structures of two potent neutralizing #antibodies that bind to the #SARSCoV2 spike #protein #openaccess dlvr.it/S2sl6k

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Filippo Mancia@pippomancia·23 Haz

It's a real pleasure for #ManciaLab to be part of this superb international collaborative effort lead by @MoronisLab! Congratulations to all those involved!

Paolo Swuec@PS_cryoEM

Excited to finally share my first #cryoEM adventure in Membrane Protein-land 🍾 out now in @MolecularCell! We captured key gating movements of HCN4 ion channel. This also my last structure on my previous Talos Arctica 🥰#TEaM200kV 👉sciencedirect.com/science/articl…

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Rosemary Cater, PhD@RosemaryJCater·16 Haz

1/9 Did you know that your brain has tons of #omega3 fatty acids like DHA in it but can’t make them? Here @Nature is our #cryoEM structure of MFSD2A that transports DHA across the #BloodBrainBarrier to fuel your brain! 🐠➡️🧠 @pippomancia #ManciaLab go.nature.com/3xtQhpE

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Filippo Mancia@pippomancia·16 Haz

#ManciaLab latest in @Nature! Check out our structure of #DHA lysolipid transporter MFSD2A go.nature.com/3zAao7Q - Congrats @RosemaryCater1 & fantastic team of collaborators @columbiaps @WeillCornell @GeorgeKhelashv1 @dukenus @OliBClarke @uazresearch @michaeltmarty @UChicago

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Keşfet

@lawrenceshapiro @ColumbiaBiochem @ColumbiaGenDev @NatEyeInstitute @SEMC_NYSBC @Frances84469032 @BobGrassucci @zhang_zhening