@bowtiedpup

If you have a CFO at a private biotech, it is in no way a full time job. Don’t overpay someone to fake work on spreadsheets. True even before AI… @BowTiedBiotech

@BowTiedBiotech - "mental health" is mostly astrology (outside of CBT). I'm not sure that therapy is net positive for most people at all. That's before they give people very dangerous/dependency creating and ineffective SSRI/SNRIs/etc. Actually effective drugs are def. needed.

@BowTiedBiotech biospace.com/drug-developme… Big Pharma in psychedelics with the best in class and actual ip will matter more than Compass or MindMed….

Israel should stop treating Muslims as citizens with full rights, they think it gives them political protection, but it’s slow motion demographic disaster and they get zero credit anyway from Jew haters.

Look guys, I don’t know much but it’s a huge miss that this is isn’t called Clankster

@BowTiedBiotech The greatest flex for a small biotech is not even going. Few

JPM Isn’t a Conference. It’s an Audit. What 1,000 companies and 6 years of data quietly tell you about biotech translation. Part 1. Why you should care. JPM decides who looks fundable before a single new dataset drops. That sounds backward, but it is how capital actually moves. If you build drugs, JPM shapes which programs survive long enough to matter. If you invest, JPM shows you where translation friction hides before trials fail. This thread breaks down what the data says. And what it implies for how drugs should be built going forward. Data from Kevin Thomas from Gosset on the HR App

@BowTiedBiotech Never

@theworldmad I thought you retired???

Earlier this week…. $PYXS -60% The signal is real enough to warrant enthusiasm, but it’s built on sand until we see DoR and how AIBW dosing tames the 56% grade≥3 / 28% discontinuation problem. If those two points resolve favorably, MICVO has a plausible path to a registrational mono study in 2L+ HNSCC; if not, this stalls as “interesting Phase 1 biology. The market continues to punish the encouraging but show me more story

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Suck on this peasants. 🇺🇸 circa 2011

Rules for making it in 2025 and beyond. 1) You don’t “make it” by begging for raises. You make it by becoming your own boss: own time, equity and optionality 2) W-2 is fixed income with obligations. Owner = variable income *and* unlimited upside. Risk = Reward 3) A flex isn’t materials it's no alarm clock. This is how leverage is made 4) Ownership mentality: sales, code and marketing. Distribution you control and Products with recurring revenue. Making money in your sleep. Reinvest profits 5) Start simple: Solve *one* problem for *one niche group. Deliver faster than expected. Repeat 6) Ideas are worth nothing, execution is everything 7) Your first $1K/month, idea is proven. First $10K/month, you're free. Scale to infinity 8) Three Nos: No meetings without purpose. No projects without timeline. No revenue generation? Pass. 9) Learn to sell or AI eats your lunch. Sales is proof of revenue. Everything else is an L. 10) KPI Tracking: monthly metrics kill bad days/weeks. Quarterly review vs. last year 11) Ads are a license to print money: Target market x Offer x Conversion x Profit = Freedom 12) Risk management: W-2 is a single point of failure. Owner risk is under your control. Diversify through skills 13) Lifestyle in check: Inflate assets yearly vs expenses. Expanding profit line always 14/ Freedom stack: time for money -> performance based -> earning when you're not working - ads run in background 15) You will have many losses. It's the only way to learn and get better. Good luck.

@Josh__Hardman @Psyched_Alpha Love to see it, well deserved

Nice problem to wake up to: upgrading our @Psyched_Alpha web hosting as we have exceeded our monthly traffic quota. Another proxy for surging interest in the space?

Mamdani Moves Mayor's Office Under Children's Hospital buff.ly/r6XKMWR

@WallStreetMav Is this captured in the inflation metrics?

$200 per protestor doesn’t go as far as it used to.

Another day another no difference whatsoever in your life because of the government shut down.

They aren’t happy about this. The Trump coalition was always fragile one but due to their arrogance they pushed too hard.

@charliekirk11 This matches another video i saw where most African languages don't have a word for the concept of maintenance.

I strongly recommend watching this, I really learned a lot.

Boomers will sacrifice the young every chance they can get (see Covid), and we are shocked why people don't have kids... Boomers will always be the worse. Basically free communism for them and poverty for the young.

Democrats During Covid: Shut down the schools and economy, saving the life of 1 white grandma is our obligation Democrats Now: Lettings black people get killed in cities is normal and good, we must not complain about violence. Soooo, white supremacy? @Cernovich @JoshuaLisec

@george__mack Yeah… I follow, but you should delete this