Max Tischfield

@jonykipnis I started to read her perspective piece on work-life-balance and found it interesting. She brings up some interesting points. Timely subject for discussion!

My wife will be giving TEDx tomorrow. If you’re on campus, stop by for an inspiring talk!

@ChrisMurphyCT Lucky kids. I would have loved this experience as a child and I’m sure they appreciate your time. 👏

My “kitchen cabinet” isn’t a group of DC advisors. It’s a a group of Hartford middle schoolers that live in my neighborhood and I meet with regularly. We met today and talked about the federal budget. They were surprised we spend more on the military than their education!

Beautiful work from Da Mesquita group ⁦@MayoClinic⁩ || Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron cell.com/neuron/fulltex…

@SD_Ackerman Congrats!!

Thank you so much for the support, and congratulations to all! 🥳

@jonykipnis Indeed, he did a great job! This work is exciting, with tons of potential....i think Zach may test the technique on our models. He definitely has the engineering mindeset, as you said. Great review in Neuron BTW, mandatory reading for my lab👌

@tischfield Yes, I figured that out after I read the paper. Very well written! 👏

somehow I missed this exciting work. Sounds very promising. Wow!!! || nature.com/articles/s4158…

Excited to share new work by ⁦@lcdsmyth⁩ et al in collaboration with Rupal Mehta ⁦@RushUniversity⁩. ACE points drain amyloid in mice and humans || Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease rupress.org/jem/article/22…

Happy to share this recent commentary by our lab (Dr. Zach Papadopoulos) on the use of low-intensity focused ultrasound to treat insults to CSF drainage and neuroinflammation following stroke. I am excited about the potential applications of this system for stroke and much more!

A postdoc position is open in the @AgalliuLab for a scientist with a strong PhD background in Neuroscience, Neuroimmunology or Vascular Biology and interest in neurovascular / BBdysfunction in CNS disorders. Please contact me with your CV and cover letter if you are interested.

Thanks to @RutgersU_News for highlighting Dad's election as a fellow of @BiophysicalSoc. Dr. Kenneth Breslauer's entire academic & research career has been spent at #Rutgers & this honor brings pride to our family and the University community at large! rutgers.edu/news/rutgers-c…

@ralfhadams Thank you, and same to you, Ralf. Your work over the years has been inspiring and I learned a lot from your upcoming magnum opus that is about to be published in Angiogenesis. Given the new direction of our work, I may need to also venture into the skull bone marrow field😉🤔

@tischfield @jonykipnis Thank you so much, Max. Looking forward to meet you in person at a conference or elsewhere

Much earlier than expected, it is time for another short thread on a recent preprint at bioRxiv (Yang et al., doi.org/10.1101/2025.1…) by a group of authors led by Dr Anjali Kusumbe. Today, I want to cover some of the bioinformatics results presented in their preprint. As a reminder, based on the reanalysis of our scRNA-seq data from Koh et al. (PMID: 39537918), it is claimed in Fig. 1 and the accompanying text that lymphangiogenic markers are downregulated in aged skull samples. We now had the chance to closely examine the relevant data, which has uncovered a couple of major issues. 1/4

@ralfhadams @jonykipnis Our experience has been the same. It’s very, very difficult to sort these cells—and contamination is abundant—if not done carefully. I am hoping for better yields next month, adhering to protocols derived from Jony’s lab🤞 Appreciate this thread—something useful again on X!

@jonykipnis Very interesting! Thank you for sharing this information, Jony.

@ralfhadams @HaoYin20 @KusumbeLab Indeed, Ralf is correct. No doubt about it.

@KusumbeLab These are vessels in the dura mater!

Endomucin immunostaining of a cleared young mouse skull reveals a continuous vascular network in the parietal bone, enabling high-resolution 3D visualization of cranial blood vessels.

@jonykipnis @AmericanAir @JAL_Official_jp I had similar problems last week on my return flight home from Japan but at least United reimbursed me without asking—or maybe that was due to my premier status🤷 too long a flight w/o internet. $35 is ridiculous.

Why is it that on my way to Japan on @AmericanAir I pay $35 for internet, which is down 80% of the time and the remaining 20% it is extremely slow, but on my way from Japan on @JAL_Official_jp, I pay $18, and the internet is solid and fast the entire flight? And I am not comparing the food and the service, because there the scale is totally different...

@PTenigma At this point all we can do is hope for a miracle. I am at the 12% for ADRD with new investigator status. Have you heard anything re: new investigator paylines? I will contact my PO next week to see what advice, if any, there is heading into the next fiscal year.

I'm not sure - like anyone else, I'm only listening to the news and talking to people I meet and at NIH, but ~40% of people I talk to think 44% cut will happen, ~20% think no cut will happen and politicians will fix it (I doubt it) +40% think something in between (~20% cut to NIH for the NIH Fiscal Year starting Oct 1 2025). The plan I saw from NINDS (link below) assumes the cut will go ahead, see page 5, so now (after my conversation on Friday with the NIA PO) it looks to me that there is some evidence that it is being built into current decisions re funding between now and Sep 30 - officeofbudget.od.nih.gov/pdfs/FY26/inst… as well as the known multiplier effect of a cut on new grants [1] which depends on the planned ratio of new to continuing grants which I simulated here [2] and is also in the NINDS FY26 plan above [1] x.com/PTenigma/statu… [2] x.com/PTenigma/statu…

I spoke with an NIH program officer yesterday who said that, given the massive 44% cut planned for NIH, they were only planning to award about 12 new grants before the end of the year, which are mainly ones in the 1st and 2nd percentile, so the 3 grants we had with good scores (usually fundable: 4th percentile, 13th percentile, and Impact Score=21) are not likely to be funded. 🤯The logic was that they are trying to maintain funding for clinical trials that are already in progress, as well as funding for ADRCs (30 or so Alzheimer's Centers across the U.S.). This also means that noncompeting continuations (of active grants) are likely to be awarded to the extent possible (which would be great if we had any), i.e. keep those going rather than award new grants. 🤯One group of people replying to the thread below (about limiting grant submissions) think that PIs who write a lot of grants are gaming the system, but most of the grants we get funded are on about the 3rd attempt (3rd submission) and we used to win about 1/4 of them after 3 tries, so it would take 12 tries to finally win one R01, often after many years of improving it. And in some of the R01s where I was PI, I would allocate 90k-100k USD to my own lab, while helping several other labs to get money (which is presumably a good idea, as our studies are collaborative). 🤯The new rule might actually be a good idea (I can't tell, several +'s and -'s are noted in the thread below) but it's not like we're winning them very often...

@jonykipnis “I was stuck on the phone with the business office” Lately, more true than ever🤨

Physicians are often late and they always have a great excuse of “I had a patient”. Surgeons, and especially neurosurgeons, think it’s mauvais ton being on time… Those of us with PhDs need to come up with an excuse equivalent to “I had a patient”/“OR took much longer”… Ideas?

@jonykipnis Thoughts and prayers, wishing safety for your family and everyone else. Very, very concerning times--for all jews, everywhere🙏🙏

I never wanted to be in a war zone as much as I want now… my wife and son are in Israel and all I wish is to be there with them and with the rest of my family and friends during these horrible times 🥲😞🤦‍♂️🙏

@lcdsmyth @jonykipnis Best of luck to you, Leon!! You will do great. May your prospects in Australia look better than what we currently face in the US.

@jonykipnis @MonashUni It's been a blast! Will miss y'all!

These goodbyes are never easy. Another pillar (Leon Smyth) is leaving us to start his own lab at ⁦@MonashUni⁩. The science in Australia just got even better! Best of luck, Leon! Can’t wait to witness your lab’s future discoveries! 🙏🥹❤️🥂

👏👏👏