Tony Soprano
113 posts


この変化すごすぎない????


















We built a topical dutasteride designed to block DHT at the follicle instead of across your whole body. Now we have human data. Oral dutasteride works, but it suppresses DHT everywhere, which is what drives the sexual and mood side effects people worry about. We wanted the DHT blockade where hair grows, and nowhere else. So we screened more than 60 delivery systems. The winning vehicle routed the drug down the follicle canal into the sebum reservoir instead of through the skin barrier. Ex vivo, it delivered 2–3× more drug to the follicle than the alternatives, while the amount taking the route into the bloodstream was too small to even measure. Then we checked human blood. In 6 patients on the topical, serum DHT showed no significant movement. For comparison, oral dutasteride suppresses blood DHT by ~90%. This is not proof of better hair growth or fewer side effects. The follicle data is ex vivo and the blood data is observational (n=6). But it's an early signal that our topical may keep DHT blockade local in a way oral dutasteride can't. We're now launching a 60-person trial in India to measure serum and scalp DHT after 8 weeks of applying Precision Dutasteride. Full report here → anagen.xyz/treatment-scie…












The first AI-designed hair loss drug on the market now has human data. We measured what MINX, our 5 mg oral minoxidil lipid-matrix capsule, does in the bloodstream. Most oral minoxidil hits your blood fast, peaks, then comes down. That sharp spike is hypothesized to be part of what drives side effects. But when MINX was taken after food, the release curve was still going up 8 hours later. The highest measured level was only ~6 ng/mL, about 6x lower than published immediate-release 5 mg oral minoxidil data, with near-complete relative bioavailability. For comparison, published standard 5 mg oral minoxidil data peaks around ~35 ng/mL in ~30 minutes. This is not proof of better hair growth or fewer side effects. But it is an early signal that MINX may behave very differently in the blood than immediate-release oral minoxidil. The data was strong enough that we filed our 10th provisional patent yesterday. Full report here → anagen.xyz/treatment-scie…

An alien who is in the U.S. temporarily and wants a Green Card must return to their home country to apply. This policy allows our immigration system to function as the law intended instead of incentivizing loopholes. The era of abusing our nation’s immigration system is over.








