Tirso Pons

@twitamit_es: El 50% de los Jefes de Investigación del CNIO (la mitad mujeres), hemos solicitado un proceso de recambio de la dirección científica del centro. Esta petición está basada en argumentos contrastables que de ninguna manera incluyen un componente de género. @CienciaGob

Updated reversions.icr.ac.uk to include lots of new cases, including from our recent paper (doi.org/10.1016/j.anno…). Now includes 759 reversions from 382 patients. Big thanks to @LorenaMagraner and @RachelAlcraft for annotations & maintenance @ICR_London @BreastCancerNow!

@eportacangen @victoriaISruiz Another tool that isn't listed in Table S1 is Structure-PPi (doi.org/10.1093/bioinf…)

Want to use protein structures to understand the impact of coding variants? Check out 3Dmapper by @victoriaISruiz Neat tool with great documentation! academic.oup.com/bioinformatics…

Circulating microRNA signature predicts cancer incidence in Lynch syndrome – a pilot study Interesting: BMI-associated c-miRs predict LS cancer incidence within four years. aacrjournals.org/cancerpreventi…

Dido1 and diet-induced obesity 1- PNAS: doi.org/10.1073/pnas.2… 2- EL PAÍS: elpais.com/salud-y-bienes…

A guidebook of spatial transcriptomic technologies, data resources & analysis approaches🤠 A great ending for my 2-wk learning of #SpatialTranscriptomics tools Start reading real-world #SpatialOmics & preparing for @IVBM2024😆 @CSB_Journal 👉Jan 2023 sciencedirect.com/science/articl…

¿Cómo que no hay investigadores en Biociencias de menos de 40 años en la @ComunidadMadrid a quien pueda merecer premiar? ¡No se puede creer! elpais.com/espana/madrid/…

R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response dlvr.it/StNZND

Clustering algorithms report clusters even when none exist. In single-cell RNA-Seq pipelines, novel cell types are often identified by clustering algorithms. Expanding on Kimes et al.'s work, we introduce significance analysis for single-cell RNA-Seq data: nature.com/articles/s4159…

Top 50 most popular tools for pathway analysis. 1. Overrepresentation analysis (ORA) using a gene list 2. Functional class scoring (FCS) using expression data or some metrics. Based on a survey by @mdziemann's group journals.plos.org/ploscompbiol/a…

This is AMAZING; a piece of art that puts into historical context the discovery of the pathogenetic basis of colorectal cancer: RAS, APC, MSI, MMR genes in Lynch syndrome. Thank you Rick Boland, @MattYurgelun et al. for this article. pubmed.ncbi.nlm.nih.gov/37402979/

A draft human pangenome reference nature.com/articles/s4158…

Lynch syndrome: a single hereditary cancer syndrome or multiple syndromes defined by different mismatch repair gene… pubmed.ncbi.nlm.nih.gov/37142200/

NCBI just released the count matrices for thousands of RNA-Seq 🧬 experiments on GEO 🎉 an amazing resource 🤩 #RNASeq #Transcriptomics #Bioinformatics #OpenScience #OpenData ncbiinsights.ncbi.nlm.nih.gov/2023/04/19/hum…

New data from our group and analysis of previous evidence question the causal role of germline WWP1 variants in PTEN-hamartoma-tumor syndrome (PHTS)-like and gastrointestinal polyposis predisposition as an alternative to PTEN mutations. authors.elsevier.com/sd/article/S23…

Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer cell.com/cell-reports-m…

R for Biologists ! Follow the link #R #rprogram #classroom_vipin #biotech #bioinformatics youtube.com/playlist?list=…

RNA-seq preprocessing and sample size considerations for gene network inference biorxiv.org/cgi/content/sh… #biorxiv_bioinfo

Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond dlvr.it/SfrYxF

It’s finally out! Go check how we’ve integrated genomic, transcriptomic & methylomic data to obtain the most comprehensive map of CRC genetic predisposition ⁦@idis_research⁩ ⁦@GMXenomica⁩ nature.com/articles/s4158…