Trinity Cookis

281 posts

Trinity Cookis

@trincookis

PhD Candidate in the Nogales & Tjian/Darzacq groups @berkeleyMCB

Katılım Eylül 2010

297 Takip Edilen467 Takipçiler

Sabitlenmiş Tweet

Trinity Cookis@trincookis·3 Oca

Streptavidin grids have saved my PhD! Hope others find our protocol useful for their own samples!

The Nogales Lab@NogalesLab

We have received a lot of requests for help with making streptavidin affinity grids. We are happy to finally share our protocol for robust in-house fabrication of streptavidin affinity grids. Stay tuned for the accompanying video that is coming soon! app.jove.com/t/66197/strept…

English

8.7K

Trinity Cookis retweetledi

Armand@armandcognetta·11 Mar

Announcing General Proximity's $12M, 2x over-subscribed, pre-Series A round. Medicine is in the dark ages. Our understanding of biology far exceeds our ability to perturb it therapeutically.

English

119

10K

Trinity Cookis retweetledi

Armand@armandcognetta·6 Mar

There’s an enormous gap in the longevity field that almost no one is talking about. No existing therapeutic modalities are capable of both systemic distribution and complex transformations. Until we solve this, we won’t solve aging. 🧵

English

122

26.8K

Trinity Cookis retweetledi

The Nogales Lab@NogalesLab·20 Eyl

And our work on the activation of automethylated PRC2 by dimerization on chromatin has just been published in @MolecularCell. Congratulations @paulvictorsauer, Egor, @poepsel_lab and everyone else who contributed to this work! cell.com/action/showPdf…

English

158

24.5K

Trinity Cookis@trincookis·3 Nis

@HoorayForZinder Also would recommend pepsin treatment O/N at 37 C - helped me unclog columns in the past

English

Trinity Cookis retweetledi

Meagan Esbin@EsbinMeagan·22 Şub

New study on #transcription regulation in human #placenta development - we find that the transcription factor #TFEB is required for the differentiation of a fusing cell type in the placenta (syncytiotrophoblasts) by controlling cell-cell fusion! biorxiv.org/content/10.110… 🧵

English

11.7K

Trinity Cookis@trincookis·15 Şub

@zhadyra_yerkesh Thank you 😊

English

Zhadyra Yerkesh@zhadyra_yerkesh·14 Şub

Congratulations @trincookis 🥳 so great to see it out!

Trinity Cookis@trincookis

Happy to share the preprint of my first research paper from grad school on how the epigenetic silencer PRC2 is inhibited by histone modifications found at actively transcribed genes - check out the thread for more details!

English

267

Trinity Cookis@trincookis·13 Şub

@ludicroce @NogalesLab Thank you Luciano!!

English

Luciano Di Croce@ludicroce·13 Şub

Beautiful work Trinity. Congratulations to you, to Eva @NogalesLab and the all team !

Trinity Cookis@trincookis

English

1.3K

Trinity Cookis@trincookis·12 Şub

The Nogales Lab@NogalesLab

Check out our latest work on PRC2 and its inhibition by active transcription histone posttranslational modifications led by @trincookis and work from twitterless undergraduate Alexandria Lydecker, @paulvictorsauer, and @vignesh_k757 biorxiv.org/content/10.110…

English

12.9K

Trinity Cookis@trincookis·23 Kas

What a privilege to work with you 🥰💪🏻🏅

The Shaw Prize@ShawPrize

“While science can be a challenge… All that pales in comparison to the thrill of the questions to be asked, of seeing them answered one day.” Prof. Eva Nogales’ acceptance speech at 2023 #ShawPrize Award Presentation Ceremony. youtu.be/PANxrHC-wfw @NogalesLab @UCBerkeley

English

3.4K

Trinity Cookis@trincookis·14 Eki

Happy to see our work on @biorxivpreprint on the activation of PRC2 through automethylation and dimerization! Great collaboration between @poepsel_lab, @paulvictorsauer, Egor Pavlenko, @NogalesLab, @KarissaScience, @EpiStrucStab

English

3.6K

Trinity Cookis retweetledi

The Nogales Lab@NogalesLab·14 Eki

Check out this thread on our story on activation of PRC2 through automethylation and dimerization! Awesome team effort from @paulvictorsauer, Egor Pavlenko, @poepsel_lab, @trincookis @KarissaScience and the rest of our twitterless collaborators!

English

105

16.7K

Trinity Cookis@trincookis·29 Eyl

@AutophaZeke @biorxivpreprint @MinghaoChen10 Congrats Zeke! Awesome work!!

English

Zeke Cook@AutophaZeke·29 Eyl

Happy to say the first paper of my PhD is now up on @biorxivpreprint ! I discovered an activation pathway of an essential protein complex and unexpectedly found that VPS15 is a pseudokinase that binds GTP! Thanks @MinghaoChen10 and Snow Ren and all authors for a great collab :)

Hurley Lab@TheHurleyLab

New preprint! @AutophaZeke’s PI3KC3-C1/RAB1A structure reveals that VPS15 is a GTP-binding pseudokinase that repurposes the kinase fold to regulate a myristoylation, and stabilize a large rotation in the VPS34 lipid kinase to promote membrane binding and PI(3)P synthesis!

English

Trinity Cookis@trincookis·26 Eyl

@danteshepherd I love this 😍

English

Luke Landherr@danteshepherd·22 Eyl

We made a 16-page comic explaining what chemical engineering actually is, through AIChE support, with art by the great Monix Keszler, and script help by my undergrad Ira Hysi. Probably the best educational comic I've ever made. Feel free to use and share! northeastern.edu/landherr/stem-…

English

157

27K

Trinity Cookis@trincookis·14 Eyl

@LugerLab Congratulations!!!

English

114

Trinity Cookis@trincookis·3 Eyl

I had a fantastic time attending my first #cshlmoet meeting - thanks to the organizers for putting together such a great program. Hope to see many of you again in 2025 for more fruitful discussions

English

3.4K

Trinity Cookis@trincookis·22 Tem

@BioS_ME_Alsace @paulvictorsauer @BJ_Greber @IsraelF96135088 Thanks for sharing this! We will have to try that!

English

148

BioS-ME@BioS_ME_Alsace·22 Tem

@paulvictorsauer @BJ_Greber @IsraelF96135088 there is: as presented in our article here, we don't wait for carbon to age, and we age it artificially with liquid hexane. We typically to all steps (carbon pre-coating, aging, and crystallization) in only 1/2 day.nature.com/articles/s4146…

English

1.2K

Israel Fernandez@IsraelF96135088·21 Tem

Try 2 with WonderWoman Zoe Watson on streptavidin grids… looking better! This is neg stain btw! 4 more grids to go…

English

4.2K

Trinity Cookis@trincookis·20 Tem

@IsraelF96135088 @TheBlanchardLab @cate_lab We have developed an optimized protocol in @NogalesLab together with Bob Glaeser to help users of streptavidin grids troubleshoot these types of issues. Happy to share the current version with anyone and we hope it will be out soon!

English

181

Israel Fernandez@IsraelF96135088·20 Tem

Today I learn a lot helping Zoe Watson with streptavidin grid production! Zoe is now a postdoc ⁦@TheBlanchardLab⁩ and she was well trained at the ⁦@cate_lab⁩ Can you see the strep xtal growing on the grid 👇🏽👀? Cryo image from our humble Talos L120C

English

10.6K

Trinity Cookis@trincookis·3 Haz

@DaireGannon @adrianbracken @GerardLBrien @tcddublin @tcdgenmicro Congratulation!!

English

131

Dáire Gannon@DaireGannon·2 Haz

Delighted to have passed my PhD viva today! Thanks to Prof. Yang Shi and Prof. Alastair Fleming for a great discussion. Huge thanks to my supervisor @adrianbracken and to @GerardLBrien for all of their mentorship over the years! @tcddublin @tcdgenmicro

English

3.2K

Trinity Cookis retweetledi

The Nogales Lab@NogalesLab·31 May

A special day for our fearless leader. Congratulations to both Eva, @CramerLab, and all of the lab members who contributed toward our understanding of the molecular mechanisms of transcription initiation.

The Shaw Prize@ShawPrize

The #ShawPrize in #LifeScienceAndMedicine 2023 is awarded in equal shares to Patrick Cramer and Eva Nogales for pioneering structural biology that enabled visualization, at the level of individual atoms, of the protein machines responsible for #genetranscription. #ShawPrize2023

English

269

52.3K

Keşfet

@MolecularCell @zhadyra_yerkesh @ludicroce @NogalesLab @biorxivpreprint @KarissaScience @EpiStrucStab @AutophaZeke