vosslab

We are looking for a motivated PhD student! #SPPL3 #Golgi #glycotime

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!

Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: doi.org/10.1093/nar/gk…. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

Don't miss the 2025 Gordon Conference on "Lysosomal Diseases" in California (March 2 - 7, 2025)! grc.org/lysosomal-dise…

Nikita Sergejevs @NickoSunway123, Pedro Carvalho & team find that that the intramembrane protease SPP conducts topology surveillance of CYP51A1 by initiating quality control of incorrectly inserted molecules. Highlight: journals.biologists.com/jcs/article/13… Article: journals.biologists.com/jcs/article/13…

Our final 2024 issue! Highlight: New players in lysosomal sorting via mannose-6-phosphate mRNA deadenylation & decay relations Plant ALBA proteins facilitate m6A reading and lots more! Cover: Grishma Rane @GrishTweets, Dennis Kappei @denniskappei et al embopress.org/toc/14602075/4…

Interesting paper by Verkerk et al. further supporting that loss of #SPPL3 can lead to tumour immune evasion. onlinelibrary.wiley.com/doi/10.1002/ej…

Great collaboration with the @voss_lab out now in EMBO Journal! Congratulations Matthias for this nice work!

Our new manuscript has been published in eLife. We describe a new method for identifying suitable E3 ligases for PROTACs. Many thanks to everyone involved. pubmed.ncbi.nlm.nih.gov/39641357/

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway Sabrina Jabs, Matthias Voss et al embopress.org/doi/full/10.10…

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway | The EMBO Journal embopress.org/doi/full/10.10…

Out now: Our collaborative #Golgi #glycotime story, which shows (i) that B4GALT5, a Golgi enzyme, is subject to M6P tagging and (ii) that GOLPH3/GOLPH3L stabilize LYSET and the GlcNAc-phosphotranferase complex and thus are crucial to cellular M6P tagging. tinyurl.com/jkv26nhh

New review on the proteolytic cleavage of #Golgi enzymes and its impact on cellular glycosylation #glycotime #Golgi #SPPL3 doi.org/10.1016/j.bbag…

I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or tinyurl.com/yrv4bh22 Get in touch with me! Repost & spread the word!

We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!

Happy Golgi Day

Sekine group is recruiting for curious minds! 🧬🧫🧪🔬Please apply or spread the word 🗣️ ki.varbi.com/what:job/jobID…

Exciting and comprehensive paper - and notably another study that underscores the physiological relevance of SPPL3

Finally managed to find time for another round of #cytosis with the lab.

@hirenj ... or a protease-independent process. Curious also from which tissue(s)/cells NDST1 here is coming.

@hirenj Interesting - and we really don't have much of an idea of SPPL3 regulation. With the many substrates known, not sure it could actually catalyse a somewhat selective release of only one Golgi protein. Could also be another protease at play here...

nature.com/articles/d4158… Obviously lots of circulating glycoproteins, but my eye was drawn to the NDST1 association. Could this actually be suggestive of a hypothetical protective effect of increased shedding by SPPL3? @voss_lab ?