



Vun-Sin Lim, PhD
1.2K posts

@vs_lim
Managing Editor of the Journal of Thoracic Oncology | Tweets are my own | Bluesky handle: https://t.co/K8lNk59Kq3





New in @JThoracOncol: 📌 Compound (PACC/PACC AND PACC/classical) mutations both show enhanced sensitivity to 2nd-gen TKIs (afatinib) over osimertinib in 1L 📌 PACC pts on 1L osimertinib trended toward shorter ToT vs classical (19.5 vs 28.5 mo) 🧬 Bottom line: When you see a compound mutation with a PACC component (G719X, S768I, E709X) — even if paired with L858R or Ex19del — treat it as PACC. Consider 2nd-gen TKIs over osimertinib. ⭐️Still an area of unmet need! Novel agents like firmonertinib, silevertinib enozertinib are being studied. Great effort by @LeXiuning and team! jto.org/article/S1556-…



According to DESTINY-Lung03, T-DXd showed durable antitumor activity and a manageable safety profile in previously treated HER2 IHC 3+/2+ #NSCLC, supporting routine #HER2 IHC testing in diagnostic workup. Read more: bit.ly/4dai726























