William Choi

How do psychedelics alter brain activity? 🍄✨ A landmark study published this week in @NatureMedicine by CPCR researchers @FredBarrettPhD, @winstonian3 and a global team of collaborators analyzes the largest human psychedelic fMRI dataset to-date.

🚨 A major Phase 2b trial of psilocybin for treatment-resistant depression just dropped in JAMA Psychiatry. The shock: it MISSED the primary endpoint The save: secondary data still show clinically meaningful antidepressant effects. Let's see if that matters 🧵

Spent an incredible and busy past few days at the #ANPA 2026 conference presenting on catatonia and learning about so many interesting neuropsychiatry topics + the @FASPEnews alumni reunion! So lovely to see so many familiar faces again and to share in fellowship!

Our (@zarmeen_z Jared Hinkle @sdpnayak @ExistWell) State of the Art Review on psychedelic medicine is now out in @bmj_latest. A few thoughts on why we wrote it the way we did. 🧵

And recognize the intrinsic plurality of intuitions and beliefs about death that are met (or not) during NRP. Accepting this plurality opens the door for a choice-based policy about pursuing NRP: a fair and egalitarian option for patients to choose it for themselves.

In this article, I argue that we should take care to avoid the pitfalls of the brain death debate by stepping back from trying to prove the "correct" philosophical account of circulatory death under NRP...

doi.org/10.1136/jme-20… Excited to share this new piece in @JME_BMJ on #NRP! The debate about NRP and whether it is "resuscitative" shares concerning similarities with the debate on brain death, which is facing an ideological gridlock about its legitimacy as a dx of death

The term "PSYCHEDELICS" can cover a broad set of substances, which people define differently. Risks vary by substance, so worth specifying which one(s) you mean whenever you use the term. New article led by Jared Hinkle (MD/PhD), w/ @willjwchoi (med student and researcher) & me:

Check out the full special report here! indd.adobe.com/view/5e75daed-…

We clarify different uses of the term "psychedelic" in reference to the "classic psychedelics" (i.e. psilocybin, LSD, DMT, 5-MeO-DMT), or more expansively including MDMA, ketamine and ibogaine, and their known AEs in clinical trials.

psychiatrictimes.com/view/adverse-e… Excited to share this new Psychiatric Times piece with Dr. Jared Hinkle and @ExistWell on our current knowledge of adverse events (AEs) across different psychedelics!

Do you live with chronic low back pain and depression? You’re not alone. Our research team at Johns Hopkins is studying whether psilocybin may help with pain and mood. If you’d like to learn more or see if you qualify, visit the link below. hopkinspsychedelic.org/backpain You may qualify if you… ✅ Are 21–80 ✅ Have chronic low back pain and depression for 3+ months ✅ Have no recent history of alcoholism or drug abuse

Had a llama-tastic time last week @AmerSocBioHum talking about MAID and NRP! 🦙Can’t wait for next year’s mammal!

4/ It’s a great privilege for me to have written this alongside Cantor’s perspective— from studying his Hastings Center paper during a bioethics class to publishing a piece with him, I greatly enjoyed the process of writing together, and I hope it’s an enjoyable read as well!

3/ But recognizing that dementia patients are capable of determining their own narrative can help clinicians understand that advance directives are not always an accurate reflection of patients’ unfolding narratives

mdpi.com/3042-4518/2/3/… Proud to have co-authored this piece with Norman Cantor and @MJYoung_MD on the ethical dilemma of following an advance directive for a dementia patient who contradicts it. In this point-counterpoint style paper, I take the position that

3/ Which can be categorized as microlevel, mesolevel, macrolevel and metalevel ethical concerns…read more to find out what each of these concerns entail when it comes to AI-assisted elderly care!

2/ We explore what a future of AI-assisted elderly care looks like, and provide an ethics framework called NEAAT (Nested Ethics for Anticipating Advancing Technologies) to evaluate the associated ethical concerns

🚨New paper alert! We performed a review of the state of AI tech as it pertains to elderly care, and propose an exciting new ethical framework to evaluate emerging AI tech! doi.org/10.1007/s43681…