Cristina Medina

Im your Tyler Durden 😎

I just found out we don't use the suffix 'mab' for new monoclonal antibodies anymore — now it's -tug/-bart/-mig/-ment So, for the new amyloid antibody, Remternetug 'Remter–' is a random prefix; '–ne' is for neurology and '–tug' because it's unmodified and monospecific

@SwitchedOnPop you guys please do an episode on ROSALIAs LUX 🤍🤍🤍🤍🤍

Access our new review on diagnosis, classification, and prognosis of ANCA-associated vasculitis in Nat Rev Rheum for free at rdcu.be/eL3wJ

@f_solorzano Ojalá pronto! Platican todo lo que contaste en misterios de la sala oscura, saludos!

@xtyme Hola, aún no.

Muchas gracias a todos los que han dado RT a esto. Por desgracia nadie ha preguntado por ellos en el teléfono que incluyo. Si alguien de los interesados no ha podido comunicarse con Ángel dígame y con gusto los enlazo. Él asegura que ha estado al pendiente.

3 types of hunger explained "simply" Hunger isn’t just about an empty stomach. Your brain receives signals from body composition, hormones, emotions, and even gut microbes. Here’s how the three major types work: 1️⃣ Homeostatic Hunger (Energy Balance Hunger) This is your body’s “fuel gauge.” It rises and falls based on energy needs and metabolic signals. What drives it: Ghrelin from the stomach stimulates hunger; leptin from fat cells and incretin hormones (GLP-1, PYY, CCK) reduce it. What it does: Ensures your intake matches your energy needs for exercise, growth, and tissue repair. 🟢 Example: After a long run, homeostatic hunger pushes you to replace calories and glycogen. 2️⃣ Hedonic Hunger (Reward-Driven Hunger) This is your “food pleasure” system. It’s triggered by sight, smell, habits, and emotions, not by actual energy needs. What drives it: Brain reward circuits activated by highly palatable foods (sugar, fat, salt). What it does: Encourages eating even when you’re not truly hungry. Weak satiety signals make it harder to stop. 🟢 Example: Craving dessert after dinner even though you’re full. 3️⃣ Microbiota-Driven Hunger (Gut Microbe Hunger) Your gut bacteria also shape hunger signals by producing metabolites that influence hormones and the brain. What drives it: Microbes generate compounds that mimic hunger or satiety signals, affect insulin, and modulate ghrelin, GLP-1, and PYY. What it does: Links gut health to appetite regulation and metabolic control. 🟢 Example: Certain bacterial imbalances may increase cravings or weaken satiety, nudging overeating.

💉 IVIG (Intravenous Immunoglobulin) 🔹 What It Is 🧪 A sterile preparation of pooled IgG antibodies derived from the plasma of thousands of donors. → Acts as immune support or immune modulator, depending on indication. 🔹 Mechanism of Action ⚙️ 💭 Depends on indication: •🛡️ Immunodeficiency: Provides passive immunity (antibody replacement). •🔄 Autoimmune / Inflammatory: • 🧩 Fc receptor blockade → ↓ phagocytosis of autoantibody-coated cells • 🎯 Neutralization of pathogenic autoantibodies • 🔥 Suppression of proinflammatory cytokines • 🌿 Expansion of regulatory T cells (Tregs) • 🧊 Inhibition of complement activation 🔹 Common Clinical Uses 🏥 🧬 Immunodeficiency: •CVID •X-linked agammaglobulinemia ⚡️ Neurology: •Guillain–Barré syndrome •Myasthenia gravis crisis •Multifocal motor neuropathy •Autoimmune encephalitis ❤️ Rheumatology: •Systemic lupus erythematosus (SLE) – esp. refractory cytopenias or neuropsychiatric lupus •Dermatomyositis / Polymyositis – steroid-sparing or rescue therapy •Antisynthetase syndrome •Vasculitis (e.g., ANCA-negative or refractory cases) •Catastrophic antiphospholipid syndrome (CAPS) •Systemic sclerosis overlap syndromes 👶 Other: •Kawasaki disease •Immune thrombocytopenia (ITP) 🔹 Dosing 💊 •Induction: 1–2 g/kg total (over 2–5 days) •Maintenance: 400–600 mg/kg every 3–4 weeks (replacement therapy) 🔹 Adverse Effects ⚠️ •😣 Mild: Headache, fever, chills, fatigue •⚡ Moderate: Aseptic meningitis, thrombosis, hemolysis •🚨 Severe: Renal failure (esp. sucrose-containing IVIG), anaphylaxis (IgA deficiency) 🔹 Monitoring 🧾 •💧 Baseline renal function •🧫 Serum IgG levels (for replacement therapy) •👀 Monitor for thrombosis or hemolysis #RheumatDocX #MedTwitter #RheumTwitter #rheumatology @IhabFathiSulima @DrAkhilX @CelestinoGutirr @Janetbirdope

"Antibiotics Cheat Sheet" linkedin.com/in/shihab-abdu…

Liver Functional Tests

No había twiteado (xteado) en un rato pero esto es importante, @StarbucksMex regresa el biscuit de arándanos y la felicidad a mi vida #JuntosPorElBiscuitDeArandanos @aurixm

@mauri8a Ayyy quiero este secretooo

Encontré un aromatizante que huele igualito al de Siclo y siento que POR FIN vencí al sistema. File in: triunfos señoriles.

@MeDicenBorbon x2

Que puta verga con Boletis y Cercle

@RelatocuriosoK @threadreaderapp unroll

Antiguos Métodos Anticonceptivos Abro hilo🧵

@PopBase Bella Baxter vibes

Lorde watching the solar eclipse in New York.

👀 ⁦@techsantos⁩ podcasts.apple.com/mx/podcast/the…

🐶🐻

Not every trigger finger is caused by A1 annular ligament thickening with consecutive tenosynovitis. In this case, we have just seen today, rheumatoid arthritis is characterized by tenosynovitis of the flexor pollicis longus tendon and submuscular impingement due to proliferative pannus-like tenosynovitis, typical in rheumatoid arthritis

¿Recuerdas cuando te uniste a X? ¡Yo sí! #MiAniversarioDeX Qué es un X

@Pez_out @lasenoracora @threadreaderapp unroll

Si quieren leer la historia completa de Victoria McCandless/Bella Baxter, les dejo aquí un link con el libro de Alastair Gray en EPub (a petición de @lasenoracora): bit.ly/PoorAlasdair ¡Fin y gracias por leer! 16/16

Poor Things empezó por la mentira del marido machista de Victoria McCandless y un manuscrito encontrado en Glasgow. Aquí la chisma del libro de Alasdair Gray y su importancia para entender el contexto de la película. (🧵 con ilustraciones originales y el libro al final) 1/16