Great interview in JAMA with @mcuban about drug pricing, Cost Plug Drugs and PBMs. On the latter: "Part 1: break them up. If I were a Democrat or a Republican, that would be what I was pushing right now." jamanetwork.com/journals/jama/…
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Zach Scheiner
244 posts
Zach Scheiner
@zachscheiner
Healthcare investor @ RA Capital
SF Bay Katılım Ocak 2012
437 Takip Edilen175 Takipçiler
It is hard to imagine investors stepping up to fund any more phase 3 pediatric myopia trials, like we and others did for Sydnexis, if the FDA insists on moving the goalposts for approval.
Wall Street Journal Opinion@WSJopinion
We hope the FDA will stop torpedoing promising drugs, but the story of biotech firm Sydnexis’s battle with the bureaucracy suggests more obstacles ahead. on.wsj.com/4uth57Z
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Zach Scheiner retweetledi
Want to know the craziest part about insurance company Pre Authorization Denials ?
The insurance company defines the network of providers the patient can use
When they deny care, they are effectively saying "we don't trust the judgement of the doctors we require you to use" 🤯🤯🤯
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Zach Scheiner retweetledi
This is what happens when you systematically target an entire industry.
Biotech already runs on brutal economics with massive R and D costs and high failure rates. A handful of winners have to pay for a graveyard of failures.
Now layer on policy risk.
Mandatory Medicaid rebates under the MDRP. Deep statutory discounts under 340B. And if a drug is “too successful,” it gets pulled into government price setting under the IRA.
When returns fall below the cost of capital, investment does not politely stay put. Capital flows to software, energy, AI, anywhere the risk reward profile makes sense.
There is plenty to criticize about pharma. But the basic math still applies. If you throttle returns on the rare breakthrough, you throttle breakthroughs.
You do not get miracle cures by making the business case for curing disease worse.
Crémieux@cremieuxrecueil
This is extremely bad for biotech You can deregulate and make agencies more efficient all you want, but if the regulator can't stick to their word and approve a design whose results they then sign off on, then companies will lose their incentives to invest Too much uncertainty
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Zach Scheiner retweetledi
I've attended the National Prayer Breakfast for much of the past two decades. I staffed the President and worked on his speech there for four years. I wrote extensively about the breakfast in my first book. One purpose of the Breakfast in history has been to position presidents and political leaders in such a way that they are humbled--their remarks typically focused on ways they fell short, the nation's reliance on grace that politics and politicians can't provide, etc.
Not until this president has someone gone to the breakfast to make so much of himself, and so little of God. And he does it every year. These aren't policy disagreements. These aren't differences resulting from Church-State separation. This is Donald Trump going to a convening that has a central focus on the power of relationship with Jesus as the transformative force in the world, and he uses that opportunity to make light of prayer and suggest he'll go to heaven because he's earned his way in. He goes to a convening built on the premise that Jesus transcends all divides in society, including partisan ones, and says an entire group of people *who are specifically recruited and asked to be in the room and on the program* actually do not belong there. Like he did at a memorial service for one of his most prominent supporters, in previous years he's gone to the breakfast to directly contradict Jesus' teachings on loving your enemies.
During the Clinton years, the Clintons sat on the dais while Mother Teresa lovingly confronted him on the issue of abortion. Now, people sit at their own breakfast while this president mocks their deepest beliefs to their face. And he tells them they love it. He tells them they're lucky to have him.
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Love this analysis, worth reading the whole thread, I'm looking forward to reading the full report.
David J. Bier@David_J_Bier
Today @CatoInstitute published our report providing the first look at the fiscal effects of the wave of legal & illegal immigration over the last 3 decades. It shows immigrants created surpluses every year, by a combined $14.5 trillion, even as deficits grew
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@lindsayschwarz I love this so much! I hope your teachers who didn't come to the ceremony don't follow you here 😂
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I’m home receiving an award from my high school and all my favorite teachers (from K to HS) came to the ceremony. Including my HS biology teacher who is 💯 responsible for me becoming a scientist. What a gift to see them all again and thank them!
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Zach Scheiner retweetledi
A hilarious example of how much the administration lies and just how lacking in virtue these people are.
DHS posted a meme with the phrase "We'll have our home again," a phrase from a white supremacist song.
When asked about it by the NYT, Tricia McLaughlin denied that the phrase was related to the song: "There are plenty of references to those words in books and poems."
A NYT reporter points out that when you open the post on Instagram, the white supremacist song itself starts playing.
McLaughlin denies this is true and accuses the reporter of spreading a left-wing conspiracy theory! She says he is the one "mainstreaming racism."
They then delete the post 40 minutes after the interview.
These people just have no honor. They're hateful racists, but not even courageous enough to be honest about it. They lie like most people breathe, and when caught, pivot to another lie. To live like this degrades the soul.
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Zach Scheiner retweetledi
PSA: you are allowed to believe BOTH that border control and law enforcement is important, and ALSO that it was a grave mistake for officers to shoot an innocent US citizen in the back multiple times
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Meet Dan and Jane. Meet "antifa". Meet the "paid protestors". Meet the "far left agitators".
Yoni Appelbaum@YAppelbaum
A remarkable dispatch from the ground in Minneapolis, from @robertfworth
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Thank you for your leadership Congressman.
Rep. Jake Auchincloss 🟧@RepAuchincloss
The ICE agents committing violent crimes, including those involved in the deaths of Renee Good and Alex Pretti, must be prosecuted, and their leaders — including Kristi Noem — must be fired. I have already called for an impeachment inquiry into Noem & am now signing onto the articles of impeachment for her abysmal conduct.
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Looks like a list of 60+ CEOs without spines.
Kyle Griffin@kylegriffin1
The Minnesota Chamber of Commerce has released this letter on behalf of more than 60 CEOs of Minnesota-based companies.
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Powerful words from @PeterKolchinsky linkedin.com/pulse/i-cant-s… I hope more leaders find the courage to speak up
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Zach Scheiner retweetledi
You have to read this. Firsthand affidavit from one of the women who was there and recording the video. She talks about how Alex Pretti was directing traffic when she arrived. She watched him be killed in front of her. She's afraid to go home, worried she'll be arrested.
Josh Gerstein@joshgerstein
JUST IN: Lawyers file declaration in federal court from first-hand witness to immigration agents' shooting of a US citizen onlookers today. Minneapolis Mayor Frey said details would be used to bolster case for ousting ICE from city. Doc: documentcloud.org/documents/2650…
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Zach Scheiner retweetledi
I cannot imagine being a parent facing your worst possible pain and loss only to have the government smear him and slander him to countless millions of Americans. It's all so repugnant and vile that it's hard to process.
Jim Sciutto@jimsciutto
Statement from the family of Alex Pretti, Michael and Susan Pretti: “We are heartbroken but also very angry. Alex was a kindhearted soul who cared deeply for his family and friends and also the American veterans whom he cared for as an ICU nurse at the Minneapolis VA hospital. Alex wanted to make a difference in this world. Unfortunately he will not be with us to see his impact. I do not throw around the hero term lightly. However his last thought and act was to protect a woman. The sickening lies told about our son by the administration are reprehensible and disgusting. Alex is clearly not holding a gun when attacked by Trump’s murdering and cowardly ICE thugs. He has his phone in his right hand and his empty left hand is raised above his head while trying to protect the woman ICE just pushed down all while being pepper sprayed. Please get the truth out about our son. He was a good man. Thank you”
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Zach Scheiner retweetledi
Enraged by the murder of Alex Pretti and politicians lying about what we can all see with our eyes. Wishing strength to the good people of Minneapolis protesting, keep exercising your rights, the vast majority of this country stands with you.
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Zach Scheiner retweetledi
I'm just thinking of all the armed protestors who went to various state capitals in recent years and were not in fact massacred by law enforcement
The Bulwark@BulwarkOnline
Kristi Noem: "I don't know of any peaceful protester that shows up with a gun and ammunition rather than a sign. This is a violent riot when you have someone showing up with weapons and are using them to assault law enforcement officers."
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Zach Scheiner retweetledi
Public safety is the first duty of government. ICE is not just failing to protect public safety in Minnesota – it is an active threat to it. The president must end this operation immediately and allow for a thorough investigation by state and local law enforcement.
Republicans in Congress must agree to Democrats' longstanding demands for root-level reform: disband the paramilitary that has ballooned over the last year, end masking & warrantless street-grabs, and train to the standards of due process and professionalism fitting a free people.
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