Ed Tate

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Ed Tate

Ed Tate

@TateScience

A group of chemical biologists at Imperial College London and the Francis Crick Institute

London Entrou em Mayıs 2012
157 Seguindo2K Seguidores
Ed Tate
Ed Tate@TateScience·
Join our group as a Research Associate in Cancer Drug Discovery! See below for more on the medicinal chemistry challenges of designing novel covalent ligand series against traditionally intractable cancer drug targets imperial.ac.uk/jobs/descripti…
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Ed Tate
Ed Tate@TateScience·
We're looking for a Technical Specialist in Mass Spectrometry to join the Chemistry Department at Imperial's White City campus. Read about how the role can help us get the most of our state-of-the -art instruments tinyurl.com/4kuurhpm
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Ed Tate
Ed Tate@TateScience·
Apply for a fully funded 4 year PhD studentship researching antibody-drug conjugates (ADCs) in collaboration with AstraZeneca. Shortlisting closes by March 23rd! findaphd.com/phds/project/a…
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Ed Tate
Ed Tate@TateScience·
Congratulations to @TateScience members Leran, Dan, @Elena_De_Vita, @scottlovell34, @AndreaGoyaG, and the teams of Aubrey Miller @DrugDiscov_DKFZ, Svend Kjaer @TheCrick and Janosch Hennig @embl on their report @J_A_C_S of a potent and selective probe for KLK6!
J. Am. Chem. Soc.@J_A_C_S

A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion @TateScience @imperialcollege #ActivityBased #PancreaticCancer #Cell #Invasion pubs.acs.org/doi/10.1021/ja…

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Bubeck Lab
Bubeck Lab@BubeckLab·
Computational resources provided by @hecbiosim allowed us to see how the lipid environment could tip the balance between CD59 as an immune regulator or host receptor hijacked by bacterial virulence factors.
Bubeck Lab@BubeckLab

Excited to share new work from the lab explaining how human cells are protected from MAC pores during an immune response. Big thanks to @ERC_Research and @eBIC_Diamond for making this work possible! In collaboration with @TateScience and @pstansfeld biorxiv.org/content/10.110…

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Ed Tate
Ed Tate@TateScience·
Excited to announce CORe, proteome-wide in-cell site-directed mutagenesis screening @NatureMicrobiol! Deconvolute role of any ligandable site, reactive amino acid, PTM, and more, at scale, at endogenous abundance! Fantastic collaboration with @laboratorychild @henrybenns
Nature Microbiology@NatureMicrobiol

Out now, drug discovery for apicomplexans👉CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery @laboratorychild @henrybenns @TateScience @imperialcollege nature.com/articles/s4156…

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Aubry K. Miller
Aubry K. Miller@DrugDiscov_DKFZ·
Thanks @DocKlahn for your input! Always helpful with comments. Anyone else have experiences they are willing to share? Perhaps @StephanHacker2 @LynJonesChemBio @SieberLab @TateScience
Aubry K. Miller@DrugDiscov_DKFZ

#ChemTwitter hive mind. Can CuAAC be done on cell lysates while preserving a disulfide? The bond in question isn’t a protein disulfide, but links a Smol ligand to a protein. I guess TCEP isn’t a good reductant. Ascorbate? Asking when SPAAC and other Click methods aren’t possible.

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Ed Tate
Ed Tate@TateScience·
Many congratulations to @Elena_De_Vita, highly commended finalist in the L'Oreal-UNESCO Rising Talents Life Sciences Award!
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