Nathan LeClaire
17.2K posts
@dotpem
DevOps enthusiast and Golang/observability hacker changing the world @typesafeai. alum @docker @honeycombio @Bauplan_labs. i like barbells, EDM and Aeropress
I love all the attention DSPy is getting right now; soon, DSPy will be the only framework worth using. I only use DSPy btw.
@karpathy The only way around this is basically having no dependencies at all, which we are at in the age of LLMs. at the limit, an import will actually be having an LLM hand implement only the brnaches that you need from a public repository and, at the same time, checking for injects
I think you get worse results from LLMs if your messages are full of typos and grammatical mistakes. I’m sure this would not show up in benchmarks, but I still believe it. The models respect you less and become lazier as a result.
Claude 4.6 is a good programmer but writes insanely severe bugs constantly, it won't catch them all in audits, nor will other claudes You need codex 5.4 auditing every commit 4+ times. If you don't believe me, try it. I have an /auditcodex skill for it github.com/sterlingcrispi…
You didn't "lose your edge" in your 30s. Your methylation broke down and nobody told you it was even a thing That sharpness you had at 24 where you could work all day, go out at night, sleep 5 hours, and still think clearly the next morning wasn't youth. It was a body that could process and recycle neurotransmitters efficiently. Dopamine got made. Serotonin got made. They got used and cleared and rebuilt in a loop that ran clean Then your B12 started dropping because your stomach acid declined from years of stress and coffee on an empty stomach. Your folate utilization shifted because you've got an MTHFR variant you've never been tested for. Your homocysteine crept up quietly. Your SAMe production fell off. And now you can't focus. You're irritable for no reason. You have this low-grade brain fog that never fully clears. Caffeine used to sharpen you up and now it just makes you anxious. You forget why you walked into rooms. You used to read for hours and now you can't finish a paragraph You went to your doctor and he said "that's just getting older." Maybe prescribed something for focus or anxiety. Probably didn't test homocysteine. Definitely didn't test methylmalonic acid or run a functional B12 panel You're running a cofactor bottleneck in the one-carbon metabolism cycle that controls how your brain makes, uses, and clears every neurotransmitter you rely on to function. Actually fixing it: Get homocysteine tested. If it's above 8 you have a methylation issue whether you "feel" it or not Active B vitamins (methylfolate + methylcobalamin + P5P). Not the cheap cyanocobalamin garbage in your CVS multivitamin that your body can barely convert Creatine. Handles roughly 40% of your methylation burden and takes pressure off the whole system Eat enough protein. Methionine from animal protein feeds the cycle. Vegans and undereaters run dry here first Glycine and collagen. Glycine is the biggest consumer of methyl groups in the body. Supplementing it directly reduces demand on the cycle Fix the gut (obviously). B12 absorption requires intrinsic factor and adequate stomach acid. If your gut is wrecked, oral B12 barely touches it Your biochemistry is running on empty and every doctor you've seen has mistaken a nutrient bottleneck for time passing. I break down the full methylation pathway, what to test, and exactly how to restore it on my substack. link in bio
Wow, I totally disagree with this statement. At the current state, AI actually amplifies the developer to developer difference. If you were a 10x developer, you had good ideas + architectural clarity, this is a brutal advantage when using AI. Steering is a fundamental part of today's AI development.
