Hatem Abou-Guendia

@sherifhany اه معاك حق .. يعني الإجراءات فعلا أنقذت اليونان كدولة لكن كانت صعبة على الناس

@hatemoag بس فشخهم برضه

That's actually too low! And weird that it's that low in France and Italy!

@TheAlexArch تقدر تقدم على تمويل الاتحاد الاوروبي من مصر لشغل في مصر

أنا كنت في مؤتمر كده في جامعة أوروبية فالمحاضر بيقولهم انتو لو محتاجين تمويل للأبحاث بتاعتكم عادي ابعتوا للاتحاد الأوروبي هيديكوا تمويل أنا: طب وانا يا حاج ابعت لمين؟ الاتحاد السكندري؟!

هو الحل الأحسن هيكون اننا نزود في ماكينات الفيزا بحيث كل المحلات والخدمات يكون عندها والناس متحتاجش تمسك كاش أصلا

طب ناويين يفتحوا الجنوب العربي على أرض الصومال؟!

@Hadeeremara98 هى أيام الاجازة الرسمي مش كانت بتتخصم من رصيد الاجازات لو يوم بريدج في النص اتاخد؟ يعني لو اخدت اجازة يوم الخميس والسبت يوم الجمعة كان بيتحسب ويتخصم .. ولا الدنيا اتغيرت في وزارة الصحة؟

عمري ما خطر في بالي إن صانع المحتوي المُفضل عندي هيبقي الراجل بتاع تيك توك اللي بيقول Tips and tricks تخلّيك تاخد ٤٧ يوم اجازة بدل ٢١ يوم من غير ما يتعملك انقطاع عن العمل ولا تتحول شئون قانونية.. شكرًا لوزارة الصحة والسكان انها وصلتني لجزء من العالم لم أكن أتوقعه 😂

@porcor0sso جوة الدوران .. في كمان عبور مشاة في النص .. ميدان إيطاليا مثلا:

@hatemoag قصدك على مداخل الدوران ولا جوه الدوران ذات نفسه؟

اعتقد دوران سموحة هو ال roundabout الوحيد في العالم الي فيه اشارة مرور في نصه الي هو أصلا بيدمر فكرة ال roundabout

شخصية سليمى في رواية ثلاثية غرناطة .. زائد رغبتي في تعلم أكتر من مجال في نفس الوقت (كيمياء ونباتات طبية وبيولوجي).. فدخلت صيدلة

This I can confirm.. not only in engineering but also in medicine and biomedical research.

محمد سلام وآمال ماهر في حفلة ايه؟ ايه الرسالة اللي مصر عايزة توصلها؟

Researchers took a DNA repair gene (cGAS) from the longest-living rodent (the naked mole rat) and put it in mice This boosted DNA repair, lowered inflammation, reduced senescence, and slowed aging (less frailty and fewer grey hairs!)

A great week for immunology. The Nobel Prize goes to Tregs this year. It was a pleasure to have Prof. Sakaguchi in Turku last June. What an opportunity for early career researchers like us to discuss with him over dinner and hear his insights about science and life.

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

This 1998 paper is, without question, one of the most beautiful in the history of biology. It answers two questions: First, how does a potassium channel let in K+ ions while excluding Na+ ions? And second, how does it funnel 100 million of those ions through each second? These questions are interesting not only because potassium channels are so deeply involved in our brain's electrical signals, but also because K+ and Na+ both carry a positive charge and have similar sizes! A potassium ion has a Pauling radius (a measure of how far its electron cloud extends from the nucleus) of 1.33 Angstroms, compared to 0.95 for the sodium ion. So a potassium ion is slightly larger, but both ions carry exactly the same charge! And yet, despite these similarities, the potassium channel is “at least 10,000 times more permeant” to K+ than Na+. How did evolution sculpt such an exquisitely-tuned machine? To find out, scientists crystallized potassium channel proteins and solved its structure using X-ray crystallography. From this structure, a few things became immediately clear: First, the potassium channel’s interior measures 12 Angstroms long. And second, the channel's interior is lined with oxygens. Normally, in a cell, ions are surrounded by water molecules. They must shed these waters to pass through the pore, but that's energetically expensive to do! The oxygens inside the channel are positioned at PERFECT locations to make this totally feasible; the K+ ions shed their waters and grab onto the oxygens instead. The structure also revealed why Na+ cannot pass through. Because it is slightly smaller, Na+ ions cannot form contacts with all the oxygen atoms at once. The geometry is slightly off, giving potassium a decisive advantage. Now onto the second question. Namely, how does this channel allow 100 million K+ ions to pass each second? That is very quick, considering these ions get "held" by their contacts with oxygen, presumably slowing them down a great deal. Again, the scientists turned to structure. They again crystallized the potassium channel protein. But this time, they soaked those crystals in a liquid containing rubidium (Rb⁺) and cesium (Cs⁺). These ions behave like potassium but scatter X-rays more strongly, because they are heavier. Thus, they show up more brightly on the X-ray diffraction data. When the scientists compared electron density maps with and without Rb⁺ or Cs⁺, they could literally see peaks where the ions bound inside the channel. From this structure, they discovered that TWO K+ ions sit inside of the channel at once, separated by precisely 7.5 Angstroms. This distance is close enough that the ions "feel" each other’s electric repulsion (like charges repel!), but not so close that they destabilize the protein. This repulsion is used by the channel as a feature, rather than bug! When a third K⁺ ion comes in from the top, the electrostatic “push” kicks the ions forward through the filter. In other words, instead of ions having to crawl through the pore one at a time, the channel uses their mutual repulsion to keep the flow moving; 100 million ions per second. Beautiful paper. A classic in using 3D structures to reveal biophysical mechanisms.

We received 2 CIHR grants to support prenatal nanomedicine projects. 2 PhD positions are available: send cover, CV, 3 referees' contacts to hagar.labouta@unityhealth.to Prior experience: stem/placental biology, organ-on-chip, nanomedicine or lipid/polymer chemistry. Share widely!

In my lab, we use cytomegalovirus as a tool to understand biology. Maybe we can interrogate a virus that increases the cell size how it does it..

Preprint: CMV reshapes lymphoid immunity in aging: a single-cell atlas with predictive modeling biorxiv.org/content/10.110…

@naguib_sarah @LiGanLab @ImmunityCP Very interesting work! Congratulations Sarah 👏

So proud to share my first first-author paper from my postdoc in @LiGanLab out yesterday in @ImmunityCP! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

This is wild! Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol) @NatureChemistry nature.com/articles/s4155… nature.com/articles/s4155…