Brunet Lab

The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao! nature.com/articles/s4225…

📢 Preprint: we present a whole-mouse-brain in vivo Perturb-seq atlas, 7.7 million cells, 1947 disease-associated perturbations, moving toward direct readout of how human genetics rewires cell states & circuits in vivo. Grateful for the Team! @NVIDIAHealth biorxiv.org/content/10.648…

We are recruiting! If you are passionate about technology development, protein engineering, computational design, directed evolution, chemical biology - please reach out! (The setting is pretty nice too…)

Congratulations to @Stanford's Drs. @QinliSun, Christopher Garcia, & co-authors on their @Nature release. 🥳 They highlight an antigen-specific peripherally induced #Treg induction strategy with therapeutic potential across diverse immune diseases. 🆕 go.nature.com/4cQrog0

Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing. biorxiv.org/cgi/content/sh…

By tracking nearly every movement of a tiny fish’s life from adolescence to death, a new Science study reveals a hidden behavioral blueprint of aging—one that can predict a fish’s age or how long an individual will live. Learn more: scim.ag/4dm1GA9

The study found that young fish that spent more of their waking hours being active tended to live longer than did more-sluggish fish go.nature.com/4sa58Ta

Excited to share this work with an amazing team: @KarlDeisseroth @BrunetLab @Ravi__Nath @scott_linderman Libby Zhang Paper in Science: science.org/doi/10.1126/sc…

From the neuroscience perspective, behavior is unmatched as noninvasive quantitative readout of brain function (and best of all, it is a readout that matters). This initial lifelong continuous screen of behaving vertebrates provided a wealth of new ideas regarding progression and staging of brain function across the adult lifespan. Truly impressive work from Claire, Ravi, and the whole creative and dedicated team. Lifelong work takes a long time, even with killifish!

HUGE congrats to @clairebedbrook and @Ravi__Nath for exciting work on lifelong behavioral tracking in the killifish 🐟😎 Super cool that behavior can define discrete life stages and predict future lifespan!! Awesome collaboration with @scott_linderman and @KarlDeisseroth!

On today's podcast, we talk with neuroscientists Claire Bedbrook and Ravi Nath (@BrunetLab, @KarlDeisseroth Lab) about their new study, which found that an animal's lifespan can be predicted surprisingly early just by observing its behavior. Listen now: neuroscience.stanford.edu/news/why-do-so…

We are excited to present our new study @Nature, led by @DrDrCox and performed in collaboration with the lab of @MaayanLevyPhD, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s4158…

Congrats to CSHL @corina_amor_MD on winning the 2026 @PershingSqFdn @MindPrize! Her lab is developing a CAR-T strategy for Alzheimer’s disease that targets inflammatory aging cells outside the brain—aiming for safer, long-lasting ways to prevent cognitive decline. cshl.edu/corina-amor-ve… #Alzheimers #Dementia

Spotlight on Julia Kaltschmidt, professor of neurosurgery: Her lab studies how groups of neurons in the gut and spinal cord develop and function. stan.md/4sfuzlW @StanfordBrain @StanfordNsurg

If you are into interpretable AI and causal models, and its applications in complex biological problems you should consider this position joint between my lab and @SKonermann at @arcinstitute!

Want to understand how antibodies protect us from disease? Join our team at Arc! We are looking for a PhD-level Scientist, who will develop new approaches for profiling human antibody repertoires and discovering new antibodies. Apply here: bit.ly/HornsLabAbDisc…

✨Registration is open for the 2026 FASEB on Chromatin and Epigenetic in Aging and Disease in Malahide, Ireland✨ Featuring keynotes @DenaDubal and Yang Shi. We have speaker slots! Submit an abstract by Aug. 24th events.faseb.org/event/Chromati…

Help us give a big round of applause to the CCAD 2026 Awardees 👏 Read more in our press release ➡️ bit.ly/46FJ5Lq

Congratulations to Emma, Jing, Tony and the entire team!!! 🤩 Transcriptomic aging atlas in killifish!! 🐟🐟🐟 nature.com/articles/s4358…

🔥 So excited to share that our study "Estropausal gut microbiota transplant improves measures of ovarian function in adult mice" ♀️🐁💩 led by talented postdoc in the lab Dr. #MinhooKim 👩‍🔬 is out today at @NatureAging ! 🔥 @USCLeonardDavis nature.com/articles/s4358…