FriendsOfSinclairLab
55 posts
@sinclairfriends
The amazing group of people who support our research aimed at reversing aging in order to treat diseases and dramatically extend healthy lifespan
FDA greenlights Life Biosciences' human clinical trial on a "near total reset" endpoints.news/exclusive-fda-…
We built this demo in collaboration with a clinical pathology lab. It shows a single system doing real lab tasks: tool use, precision manipulation, and high level planning. This was done in one take with no teleop and uses our skills based AI to enable generality while staying deterministic and reliable for real world workflows. See more here: kyberlabs.ai/demos
Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of @hevolution_f and on the board of the @AFARorg. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research
Today’s guest on the Free Radicals podcast is @M_S_Ringel, COO @lifebiosciences and former Managing Director at @BCG. Michael is a leader in longevity and pharma who spent 25+ years advising top pharma companies on their R&D strategy. He is now COO at Life Biosciences where he is bringing the first ever partial epigenetic reprogramming therapy to human clinical trials - a major milestone for the longevity industry. In this episode, we discuss Michael’s insightful paper on why aging is an optimization by evolution, why that means it’s malleable, and how to push the longevity field forward. Michael also sits on the US board of @hevolution_f and on the board of the @AFARorg. Be sure to follow me and @EricDai_BioE to stay up to date on the latest news in longevity biotech! 0:00 Intro 2:30 Why aging is an optimization by evolution 15:10 Why scientists miss the role of evolution in aging 19:31 Evidence that aging is a regulated process 24:40 Hormesis and adaptive stress responses 28:55 The promise of partial epigenetic reprogramming in humans 35:08 Life Bio's first therapy proceeding to clinical trials 47:47 Why targeting the eye, particularly glaucoma and NION, is a strategic choice 52:03 The pharma industry's perspective on anti-aging research 56:39 The importance of public engagement for funding and policy change 1:05:42 Reasons for optimism in longevity 1:08:26 Advice on how to have an impactful and interdisciplinary career 1:11:54 The ethical case for longevity 1:17:34 Concrete steps for audience members to support longevity research
@davidasinclair Incredible to see how this discovery changed the game for longevity science
BREAKTHROUGH 100% Life Extension Achieved in Mouse Study @ImmortaBio youtu.be/oetFLK5z7uc
Very few factors significantly slow epigenetic aging. Strong social connection is one of them. The data keep pointing the same way: healthy relationships are a key to a long and healthy life.
