Nicholas Wu

621 posts

Nicholas Wu

Nicholas Wu

@wchnicholas

Associate Professor @UofIllinois studying influenza, SARS-CoV-2, antibodies, evolution, and protein structures.

Urbana, IL Присоединился Aralık 2014
325 Подписки884 Подписчики
Nicholas Wu ретвитнул
Marc Johnson
Marc Johnson@SolidEvidence·
This preprint just came out. @wchnicholas and team reconstructed and tested the NJ Spike and found that it has the tightest ACE2 binding of any SC2 Spike ever measured. 2/ medrxiv.org/content/10.110…
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Marc Johnson
Marc Johnson@SolidEvidence·
This is wild. Remember the NJ crytic lineage? I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out. Some colleagues took me up on it. Guess what they found? 1/ twitter.com/SolidEvidence/…
Marc Johnson@SolidEvidence

New Jersey Cryptic lineage update. Background: Cryptic lineages are evolutionarily advanced SARS-CoV-2 lineages detected in wastewater from an unknown source. We are fairly certain that these are derived from patients with persistent SARS-CoV-2 infections. 1/

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ZiqiFeng
ZiqiFeng@ZiqiFeng_·
Excited to share our recent study (collaborated with @wchnicholas @SolidEvidence) of a wild cryptic lineage, NJ, detected in wastewater. Notably, it carries 39 unique substitutions on the RBD, and exhibits the highest ACE2 binding affinity and extensive antibody evasion.
ZiqiFeng tweet media
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Cell Host & Microbe
Cell Host & Microbe@cellhostmicrobe·
Evolution of Ab cross-reactivity to influenza H5N1 NA: Isolation & characterization of protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas cell.com/cell-host-micr…
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Cell Host & Microbe
Cell Host & Microbe@cellhostmicrobe·
Evolution of Ab cross-reactivity to influenza H5N1 NA: New work isolates & characterizes protective antibody against influenza neuraminidase that acquires cross-reactivity to avian H5N1 as a byproduct of affinity maturation against human H3N2 @wchnicholas cell.com/cell-host-micr…
Cell Host & Microbe tweet media
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Owen Ouyang
Owen Ouyang@WenhaoO·
Excited to share that the oPool⁺ display is on the cover of this week's @ScienceTM! We hope that the future use of this platform can accelerate antibody characterization, benefit therapeutic & vaccine development, and facilitate iterative refinements of antibody AI models.
Science Translational Medicine@ScienceTM

Don't miss the new issue of #ScienceTranslationalMedicine! A clinical study in Nepal shows that waning immunity to Japanese encephalitis virus can worse the severity of dengue, a new platform leapfrogs laborious obstacles in antibody discovery, and more. scim.ag/3JBJc1Y

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Owen Ouyang
Owen Ouyang@WenhaoO·
Reaching out to senior scientists can feel daunting, but it’s often less intimidating—and more rewarding—than you’d expect. In this @ecrLife article, I share my experience as an early-career researcher and encourage others to take that step too. ecrlife.org/reaching-out-t…
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Siyuan Ding
Siyuan Ding@sding88·
We are hiring a highly motivated postdoctoral fellow to study the molecular biology and pathogenesis of enteric viruses that cause diarrhea in human infants. More details on the Ding Lab website - sdinglab.wustl.edu. DM or email me!
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Owen Ouyang
Owen Ouyang@WenhaoO·
In this latest version of the preprint, we are excited to (re)introduce oPool+ display, a high-throughput cell-free platform that enables rapid synthesis and specificity characterization of natively paired antibodies at an unprecedented scale (1/): biorxiv.org/content/10.110…
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Owen Ouyang
Owen Ouyang@WenhaoO·
I am excited to share our latest work, where we developed oPool+ display, a rapid and cost-approach to synthesize and screen natively paired antibodies in a highly parallel fashion (1/14): biorxiv.org/content/10.110…
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Siyuan Ding
Siyuan Ding@sding88·
The Ding Lab at the Washington University in St. Louis (sdinglab.wustl.edu) is hiring! We are looking for motivated postdocs and technicians to study rotavirus biology and vaccines using viral reverse genetics, mouse models, and human intestinal organoids. Spread the word!
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American Society for Virology
American Society for Virology@AmerSocVirol·
Ann Palmenberg Junior Investigator Awardee: Jenna Guthmiller from University of Colorado. Jenna’s work aims to understand how epitope-specific antibodies drive viral evolution and the application to vaccine design. #LoveVirology
American Society for Virology tweet media
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Yiquan Wang
Yiquan Wang@Yiquan_W·
I am so glad to receive travel award for #BPS2024. Come to the poster session on Feb 14th(B477 , 10:30 AM - 12:30 PM) to learn about antibody, deep learning and language model!
Yiquan Wang tweet media
Philadelphia, PA 🇺🇸 English
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Owen Ouyang
Owen Ouyang@WenhaoO·
I love running, and I love helping people more. In 2024, I want to combine two of my favorite things by running the @ChiMarathon as a @MercyHome hero! Please join me in helping children in need, one step at a time:) #Resolutions2024 #_ts=216028265949c31a3f94" target="_blank" rel="nofollow noopener">marathon.mercyhome.org/chicago2024/he…
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Cell Reports
Cell Reports@CellReports·
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem dlvr.it/Sz4Cs3
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@SolidEvidence @ScienceTM @ECRLife @JExpMed @florian_krammer @MichelsonPhils @GuthmillerJenna @AmerSocVirol