Agnes Noy

Come to York and fight antimicrobial resistance with Daniel Cole, @dghilarov and Inspiralis Ltd. MRC DiMeN Doctoral Training Partnership: Computational Drug Discovery Targeting DNA Gyrase to Tackle Antimicrobial Resistance at University of York on FindAPhD.com

Congrats to @JamiesonH - our latest @PhysLifeYork work dissecting the structural landscape of the Rep Helicase is now in Nucleic Acids Research! Huge team effort! @Craggs_Lab @AllisonHSquires @ANoyLab @BPSIYork @mahmoud @DrM_Abdelhamid @Single_Mole 👇 tinyurl.com/bdznxur3

Overall, HU binds DNA in a multi-step process: electrostatic interactions build up gradually until the protein locks onto its target site. This prevents HU from sticking to random DNA along the way.

The switch to high-affinity HU–DNA binding happens only at the target site, helped by DNA’s own flexibility. It suggests a concerted mechanism, bridging the gap between “induced fit” and “conformational selection.”

Check our latest publication in #JACSAu @ACSPublications with @ElliotWChan and @BPSIYork where we describe how the bacterial protein HU binds DNA at atomic resolution. Thanks to @EPSRC and @N8CIR and @hecbiosim for computational resources. See more👇pubs.acs.org/doi/10.1021/ja…

Gave my first talk at the @UniOfYork Grateful to @BPSIYork & @ANoyLab for the opportunity, and to my supervisor @joshiphy for his constant support. It was a truly enriching experience to share my work and interact with such inspiring researchers. Also thnks to @SonamRagha77827

📢 Our article calling for a #FAIR database for #MolecularDynamics simulation data has now been peer-reviewed and published in @naturemethods 📖 Read it here: rdcu.be/ef6YX 📝 Support the statement: bit.ly/3zVS3qm #MDDB #FAIRdata #collaboration

Looking forward to attending this meeting and having interesting discussions about ai vs physics-based modelling approaches 🙂

🚨🚨Please RT! 📢📢 Still time to submit short talk abstract for EdinPBS2025! Five themes this year: · Mechanobiology · Protein pattern formation · 4D Genome · Stochastic biology · Biohydrodynamics bit.ly/EdinPBS2025

This is one of the conferences where I have genuinely learned more. Delighted to contribute to this vision article.

Fundamental research into DNA “bubbles” will improve scientists' understanding of how genetic programs unfold to help in disease detection and treatment @ANoyLab tinyurl.com/3ewa2yz7

Were you interested in our last paper in @PhysRevLet but found it too complex to follow? Then look at this article by @physorg_com, where it is explained in plain terms phys.org/news/2025-02-m…

Thrilled that the paper has just appeared in @PhysRevLett. Excellent work from Matt Burman's @EPSRC -funded PhD. Thanks to @N8CIR and @hecbiosim for computational resources. Check the updated thread in @agnesnoy.bsky.social! journals.aps.org/prl/abstract/1…

Having attended the previous edition, I can vouch for how insightful this conference is. Don’t miss the chance to be part of this vibrant community!

Nearly 50% of researchers quit science within a decade, huge study reveals. women are more likely than men to leave research. nature.com/articles/d4158…

So she was first author on his key paper - in fact she's on most of his key papers, yet she didn't get the Nobel Prize, in spite of the fact they could have given 3 awards, not just 2. Explain to me how STEM is not institutionally sexist.

We visited Tony Maxwell in Norwich last week, and he kindly accommodated us at his home. He mailed the socks I forgot back to me… 😂

A fantastic outcome from @PhysicsofLifeUK summer studentship funding, congratulations @TaniaGardasevic and @ANoyLab on this lovely 🧬paper.