Alexander Chaitoff

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Alexander Chaitoff

Alexander Chaitoff

@AlexChaitoff

Doctoring + Researching @umichmedicine + @VAAnnArbor | Came for #MedTwitter but stay for #Epitwitter hot takes | Opinions My Own + Not Medical Advice

เข้าร่วม Nisan 2011
911 กำลังติดตาม1.6K ผู้ติดตาม
Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
Pharma companies had success increasing med use by sending reps to meet with docs to provide interactive educational sessions. Can that educational model be harnessed for good? Yes! Read our systematic review on Academic Detailing led by @bnrome pubmed.ncbi.nlm.nih.gov/39775805/
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@AdanBecerraPhD @AnnalsofIM I do agree, though one point to add is that though most gabapentin is used for "off-label" indications, the majority of those indications have trial-level evidence of potential benefit (just no financial incentive to get them added to the label of a generic med).
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
🚨New paper in @AnnalsofIM about everybody's favorite medication to hate🚨 Gabapentin is far from the perfect pain med, but the risk/benefit profile may be more complex than papers comparing users to non-users could have you believe Tweetorial en route! pubmed.ncbi.nlm.nih.gov/39761587/
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Alexander Chaitoff รีทวีตแล้ว
Rishi J Desai
Rishi J Desai@Rishidesai11·
In a study @npjDigitalMed led by Bowen Gu and @JieHealthAI, we find that LLMs struggle to convey uncertainty and can be overly confident in their answer even when it is wrong. Imp area for research and improvement for detection of hallucinations.. nature.com/articles/s4174…
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@ProfHayward @f2harrell I think a lot comes down to how you use the data and how you communicate the results. Extrapolating a trial to a population that wasn't studied is just as problematic as issues in observational studies. Precise communication and appropriate caveats for all study types.
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Rod Hayward
Rod Hayward@ProfHayward·
@f2harrell I have 2 thoughts abt this hierarchy: - would put good quasi-experiments b/w true experiments & ObsStudies - I see retrospective below prospective not as inherent, but serving as a marker for retro studies more likely to have low prior, data dredging, more info bias, etc
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Frank Harrell
Frank Harrell@f2harrell·
Randomized experiment > prospective observational study with sound statistical plan > prospective with unsound statistical plan > retrospective with sound stat plan > retrospective with unsound #Statistics
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@Eddie_Cliff @syctong @justin_denholm I really like procalcitonin, and along with D-dimer it's the test example I use when teaching med students and residents about how different pre-test probabilities and different cut-points for a test change posterior probabilities.
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
This is the type of education everybody, but especially pre-meds + medical students, should be getting. Journal clubs are great and can teach some about biased study designs and reporting, but there are so many more lessons for most clinicians here. #Medtwitter #MedEd
@MedEdMustReads@MedEdMustReads

This MUST READ shows how to teach about lateral reading so that individuals can thoughtfully consider whether published articles are biased or credible. @asmeofficial @UMNAlumni @ZekeMD @GlobalHealthDr @ZShaheenMdPhD @ameefacdev @GIMMedEdDoc @MedEdPORTAL tandfonline.com/doi/full/10.10…

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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
Loved what this paper set out to do, but unfortunately my reading is there still isn't good evidence to deprescribe antihypertensive medications in older adults. Come learn why 👇 #Medtwitter #Cardiotwitter
The Curbsiders@thecurbsiders

🤔 #Digest 59: Whether to deprescribe BP Meds–A Confounding Question! Plus COVID/Flu vaccine co-administration safety, GLP-1RAs in the perioperative period, tirzepatide to prevent prediabetes, and the cardiovascular benefits of activity and time in BP range. #meded

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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
Ok most people feel 2nd author is distinct from other middle authors. Follow-up for #Medtwitter / #Epitwitter health services/clinical researchers: What is reasonable to expect from non-2nd middle authors (assume original articles being submitted to clinical journals)?
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@MRothbergMD Something we thought about - in this case we tried to keep it vague and say tolerated for some time hoping folks would insert whatever threshold they had in there. I wonder if it depends on the person, or if the habit forming literature applies.
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Michael Rothberg
Michael Rothberg@MRothbergMD·
@AlexChaitoff So how long does the disutility of a new medication last? When does it switch to the disutilty of a chronic medication?
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
Hey #MedTwitter #Epitwitter and whoever else does health services/clinical research, curious your thoughts about author contributions. Question 1: Assuming >3 authors on a paper, does second author carry any extra weight over being another middle author?
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@dr_dmorgan Really like this - I've been curious the distribution of answers that physicians and patients would provide as far as their expected risk reduction and their expected time horizons for benefit for many chronic disease treatments.
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@CMichaelGibson While cool, what is the clinical use case here? My only thought was hospital at home patients, but they have IVs and could seemingly just take the pill.
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
@MRothbergMD I'd heard that before, but if somebody makes a good argument isn't that how science should work? I guess I have the time now, maybe for senior folks this becomes an issue 😂
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
For me, it's a yes. My practice is to point to very specific deficiencies that would not be addressable with the given data. If it's simply my perception of the importance, I'll try to cite something to support that. I find it adds an extra 15-20ish minutes per paper.
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
Should medical journal editors provide any feedback on papers they desk-reject? #medtwitter what do you think? Please let me know why as well.
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Alexander Chaitoff
Alexander Chaitoff@AlexChaitoff·
We need an index that describes how often your paper is cited vs how often it is read. Said index for "Crossing the Quality Chasm" would be enormous. If you had to prove you read a paper before citing it, 92% of the background sections in the medical literature would be gone.
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ค้นพบ

@bnrome @AnnalsofIM @npjDigitalMed @JieHealthAI @ProfHayward @f2harrell @Eddie_Cliff @justin_denholm