The Align Foundation

🔗 Access the dataset on the Align Data Portal: hubs.la/Q0470NBn0 👏 Huge thanks to our collaborators and everyone involved in making this dataset possible.

This is the result of a fantastic collaboration with David Ross's Lab at @NIST, @simonsnitz at @Harvard and @Damp_Lab. We’re thrilled to make the data publicly accessible to support the broader research community.

🚀 Public Data Release: GROQ-seq Transcription Factor Dataset We’re excited to announce the public release of The Align Foundation's first GROQ-seq dataset, one of the largest high-resolution transcription factor datasets of its kind.

Align and @GoogleDeepMind are partnering to build AI-ready datasets & evaluations for the future of predictive #AMR biology. Researchers worldwide can submit concepts through March 31 w/ roadmapping workshops coming to North America + APAC this spring. 🔗 hubs.la/Q044rDpL0

Designed to be scalable and with closed-loop experimentation, Tesseract will power AI to map sequence → function, predict gene transfer success, and assign function to unknown genes from rich phenotypic signatures. Big thanks to the collaborators+reviewers who helped shape this!

In partnership with @Pioneer__Labs, we’re proposing Tesseract: a large-scale, open microbial phenomics dataset to functionally annotate microbial genomes at scale. 🧬🤖 ✅5M diverse genes x 50 host strains × 100 conditions 🔗 Read the proposal: zenodo.org/records/179902…

🚀 Team growth: 2x growth in team size vs last year to support all this open science. Huge thanks to collaborators, participants, and the entire Align team. You make this possible!

🔬 ALIGN WRAPPED: our year in open science 🔬 Thread 🧵 We turned up the impact. Here are highlights from the past 12 months at The Align Foundation. Want to collaborate or learn more? ✉️ contact@alignbio.org #AIforBiology #OpenScience #ProteinEngineering #Microbes #Data

🎤 Outreach: Attended 30+ conferences to present our work, build partnerships, and spread open science worldwide.

📝 4 peer-reviewed publications: • Data Scaling • Results of the Protein Engineering Tournament • Can protein expression be ‘solved’? • The influence of automation and AI on biology

📦 Data releases: 5 public datasets (>2M data points) live in our Data Portal, plus 7 datasets under embargo (>500K data points) arriving next year and many more in the pipeline.

🌍 Global community: PETase Engineering Tournament has 200+ teams, 600 registered participants from 39 countries.

🔝 3 high-impact projects in-flight: GROQ-seq, Tournament, and Microbes are each driving new methods, benchmarks, and community experiments.

🔗 20 active research collaborations across academia, industry, and government labs; all working together to accelerate reproducible, open science.

DARPA’s Grand Challenge in 2004 sparked the autonomous vehicle industry. 🚗💡 Now, @AlignBio is channeling that same bold energy into AI-driven protein design — where algorithms meet the lab to create enzymes that tackle real-world problems like plastic pollution. 🌍🧬 🔗 Learn more: hubs.la/Q03Qxxny0 Join the teams redefining what AI and biology can do together → hubs.la/Q03QxWCH0 #AI #ProteinEngineering #ClimateTech #CircularEconomy #Benchmarking #EnzymeDesign #Sustainability #Plastics #OpenScience #PETase

The 2025 Protein Engineering Tournament is powered by: 🧬 @TwistBioscience – DNA synthesis 🧠 @evo_scale – ESM compute 💻 @modal- Hundreds of hours of powerful GPUs 📔 @nvidia – BioNeMo lab notebooks Can your model design an improved enzyme that holds up under real lab conditions? Register by Nov 14 → hubs.ly/Q03PLryH0

🌍 Turning Plastic into Progress: AI Models Compete to Design Better Enzymes The Align Foundation’s 2025 Protein Engineering Tournament challenges teams to design plastic-eating enzymes (PETases) using AI + lab testing. 🌍 290+ teams 🧪 40 countries 🤝 Backed by NVIDIA, Twist, Modal, & EvolutionaryScale Join in → hubs.la/Q03PH7Pb0 Read the full press release → hubs.la/Q03PHcXZ0 #AI #ProteinEngineering #Biotech #Sustainability #Plastics #OpenScience

@desai_bijoy is heading to European RosettaCon in Ljubljana, Slovenia on October 20th! Catch him presenting a talk and sharing a poster on two exciting initiatives at @Align_Bio. Going too? Drop a line to connect! #EuropeanRosettaCon 🧬 Talk title: The open datasets initiative and protein engineering tournament. ⏰ Time: Monday, October 20 at 3:45 PM CEST