Michael J. Robertson

Excited to share our work is out in @Nature! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins. nature.com/articles/s4158…

Nature research paper: Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity go.nature.com/4rtdvbd

@zenbrainest @Nature Thanks Bryan!

@BiophysicsGuy @Nature Truly awesome work. Congrats!!

Excited to share our work is out in @Nature! We used TR cryo-EM to visualize the activation of Gi1 and G11 from NTSR1. With MD sims & work from the Blanchard and Lambert Labs, this revealed key differences driving signaling efficiency between G-proteins. nature.com/articles/s4158…

@Nature Also check out great complimentary work by @emeKato! nature.com/articles/s4158…

New preprint from the Robertson Lab! We used AF ensemble generation for rigidity filtering with generative design to make cryoEM fiducials, enabling rapid inactive states of four drug targets and a beta2 extracellular fiducial to study GPCR activation! biorxiv.org/content/10.648…

@Ella_Maru @Nature Thanks!

@BiophysicsGuy @Nature Congratulations Michael!

Excited to share our study resolving the GTP-induced activation of the mu-opioid receptor-Gi complex with different agonists using cryoEM and MD simulations is live now @Nature, with additional MD sims, fluorescence work, and more! nature.com/articles/s4158…

Happy to share that our paper on Metric Ion Classification (MIC) is now published! nature.com/articles/s4146…

Excited to share our latest preprint! We used cryoEM and MD simulations to look at the GTP-induced activation of the mu-opioid receptor-Gi complex with partial, full, & super agonists resolving Gi activation and how its modulated by different ligands! biorxiv.org/content/10.110…

The Robertson lab has multiple openings for postdocs! Particularly interested in those with experience in either plate reader assays or ML, but all are welcome!; come learn about GPCRs, cryoEM, MD/FEP, drug discovery and more! jobs.bcm.edu/job/Postdoctor…

We are recruiting a young researcher to join our dynamic lab at UCSF - this is a great opportunity if you would like to get some research experience before graduate or medical school! aprecruit.ucsf.edu/JPF05305. Please RT!

Woohoo, our paper on the mechanism of a G protein inhibitor that is specific to one family of G proteins is out! Nice collab with the Blumer nad @AndreaSoranno labs pnas.org/doi/10.1073/pn…

@DamianYoung29 Congrats Damian!

I am extremely grateful to be awarded a $5,000,000 Catalyst Grant from the Welch Foundation. This grant will be focused on further developing the science of DNA-Encoded Libraries (DELs) for generating small molecule ligands toward a broad spectrum of disease-related targets. welch1.org/grants-program…

@CaveneyNA @PharmTox_UofT Congrats!!!

Thrilled to say that I will be joining the Department of Pharmacology and Toxicology at the University of Toronto @PharmTox_UofT this fall as an Assistant Professor!

And it's out! Structure and function of the proline transporter SIT1 in complex with ACE2 Congrats to Huanyu, Ashley, Irina, @robertvandenbe2, Liz Carpenter, @T_dafforn, and the many other collaborators from @CmdOxford, @uobbiosciences, @Sydney_Uni nature.com/articles/s4146…

Calling the #moleculardynamics community – first CASP target ever for predicting water (ensembles) around a macromolecule: predictioncenter.org/casp16/target.… Will be evaluated by direct comparison to #cryoEM on the Tetrahymena ribozyme #RNA!

"Mechanistic insights into G protein coupling with an agonist bound GPCR" Cool work led by the Hildebrand group. linkedin.com/posts/guillerm…

@lbackman21 @Jen_Cash_11 Same!

Hey all new(ish) structural biology PIs out there - I started a slack workspace geared toward us! If you’d like to join, DM me your email and method(s) of choice, and I’ll add you to the group.

1/6 Happy to share our new preprint- biorxiv.org/content/10.110… @lab_stroud, @GuptaLab_, Jeffrey Bennett, @Nikk_click, Andrew Nelson, Peter Hwang, Sergei Pourmal. Huge thanks to the funding agencies @NIHgrants @guthyjacksonfdn @UCSF (pbbr.ucsf.edu) for their support.

Our paper is finally out in it's final form!