Circulation Research

🚨JUST PUBLISHED 🚨@CircOutcomes focus issue on #CardiovascularEpidemiology led by @KBreathettMD @NorrinaA @emilycob Epidemiology is at an inflection point where we must move from description toward action-oriented science 📖 Read here: ahajournals.org/toc/circpopout… @bnallamo

5/5 USP10 Deubiquitinates MTX2 to Suppress cGAS-STING Signaling in MI by Zhao et al bit.ly/475ih7q

4/5 Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance by @ANASIMONCHICA1 et al @FilgueirasRama" target="_blank" rel="nofollow noopener">bit.ly/4cYdVmi@Filgue…

1/5 New @CircRes podcast #DiscoverCircRes bit.ly/3Ndy2Th @StHilaireLab chats with Drs. John Hall and Ana Omoto about their study Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection bit.ly/4rbYkmt

Zhao & colleagues found how a protective protein, #USP10, helps limit excessive #inflammation after a #HeartAttack, which may open new avenues for treating cardiac injury. Learn more at ahajrnls.org/4bRryCI

Pu et al found the role of #TBK1 in vascular #ECs in the development of #atherosclerosis. Targeting TBK1 is effective to suppress #EMT & atherogenesis. Learn more about TBK1 in atherosclerosis at ahajrnls.org/4sNoL38 @DrRonaldMa1 @LUOJIANGYUN @CityUHongKong

@ANASIMONCHICA1 found persistent #Afib shows differential regional changes in #fibroblast & #myeloid populations with distinctive gene signatures that drive #arrhythmia ahajrnls.org/4sbAWXS @Borjaibanez1 @CarlChiefCard @MCouseloSeijas @manuel_carnero @joa_gr

@CircRes March 13th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Color-coded myeloid cell clusters in driver (top right) and non-driver (bottom left) regions of the atria during persistent atrial fibrillation

📣 Call for Applicants! 📣 @CircOutcomes invites applications for an Associate Editor to join the journal’s new editorial team led by incoming Editor-in-Chief Dr. Dhruv Kazi @kardiologykazi 🗓Apply by April 10 🔗Learn more: ahajournals.org/circpopoutcome… @AHAScience

Caliandro et al demonstrates that a stress-responsive #RNA molecule suppresses a key repair factor in injured heart cells. Learn how removing this brake may enhance the heart's ability to adapt & recover after damage at ahajrnls.org/4bAu0NV @MonikaGladka @DeliZhang2

ICYMI: The latest episode of Discover CircRes podcast is out, and you can listen here: bit.ly/4rt43FN

Omoto et al reveal activating #leptin signaling in the #brain helps the #heart heal after ischemic injury by sending signals to #BrownFat to reduce scarring & improve heart function. Learn about a new brain–fat–heart communication at ahajrnls.org/4cuX6PQ @CVIRLab

📢 #Stroke Webinar: Translational Perspectives in Stroke: Neuroimmune and Biological Mechanisms of Recovery and Cognitive Decline, with @MarionBuckwalt2 @LD_McCullough @Chenhsbbb. 🗓️ March 12, 4:00 PM CT / 21:00 UTC 📎 Register: ahajrnls.org/4tNpmDn

@Fruberto et al found silencing of #lncRNA #CLIPPER drives productive mitochondrial fission through #LPIN1 downregulation & activates cardiomyocyte proliferation, revealing a promising strategy for heart regeneration ahajrnls.org/3OJMNgU @rsyf2 @meekelee @LUCASLU

Sakkers et al found athersclerotic #plaques in women & men are driven by different mechanisms & could lead to more precise, sex-specific strategies to prevent #athersclerosis. #GoRedforWomen ahajrnls.org/4kZQgns @Vascular_Prof @molvascular_TUM @stevejwhite777 @swvanderlaan

Larrinaga et al discovered how #Lmod2 fine-tunes muscle contraction by acting like a "leaky cap" & controlling how #actin filaments grow. Disrupting Lmod2 causes filaments to grow unusually long & perturbs beating of the #heart ahajrnls.org/4kVTFUm @IcahnMountSinai

@CircRes Jan 27th Issue is Out! ahajrnls.org/3wPOBJJ Cover: Disruption of the first actin-binding site in #Lmod2 results in extra-long thin filaments in cardiomyocytes.

ICYMI: The latest episode of Discover CircRes podcast is out, and you can listen here: bit.ly/4rt43FN