Francis O'Reilly

Well how about that

Using single-particle cryo-EM on native samples of the human parasite Toxoplasma gondii, we determined structures of four major components of the conoid, its cell-invasion machinery. This project builds on our continued collaboration with the David Sibley lab at WashU.

Excited to share our latest work with the bullock lab! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. biorxiv.org/content/10.110…

Time to get signed up for the next Symposium on Structural Proteomics! This time in beautiful Milan, 6th-8th October. ssp2025.squarespace.com

RIP Brian Wilson. Sharing BBC Music’s tribute to The Beach Boys “God Only Knows”

Despite the chaos and turmoil, our lab is blessed to have 3 new postdoctoral fellow openings and we would welcome scientists interested in: - combining single-molecule studies with cryo-EM - developing new protein design tools using bioinformatics and structure-based tools - using protein design to develop novel genome-editing tools. Please feel free to reach out to me: Elizabeth.Kellogg@stjude.org with your CV and a few sentences on what you'd like to work on in the lab.

Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. science.org/doi/10.1126/sc…

Ever wondered how several individual RBPs cooperate to repress translation? To figure it out, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! Lead by @MarcoPayr and great collaboration with Hennig lab! biorxiv.org/content/10.110…

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: biorxiv.org/content/10.110… This work spearheaded by PhD Student Sascha Amann Let me walk you through it 🧵 1/9

we are looking for PhD students using time resolved cryoEM or cryoET on topics of the ubiquitin proteasome system. However, there is freedom to shape projects in own ways.

Excited to share some work in our collaboration between @fried_lab and Ed O'Brien @psu_chemistry, just published in @ScienceAdvances : science.org/doi/10.1126/sc…. Here we describe the structural basis for stretched exponential kinetics in protein folding. A thread.

🚨Preprint, RT appreciated🙏 Our work ‘Substrate recognition by human separase’ by @JunYu_unige, Sophia Schmidt, @MargheritaBotto @unige_en @UNIGEnews @MoCel_Geneva @DCI_EM and members from the Morgan @UCSF and @FJ_OReilly labs is online. 🔗biorxiv.org/content/10.110…

Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.

@Liang_Xue_ Good luck, Liang!

I am also glad to tell (again :) that I have left EMBL and started my indepedent group focusing on cryo-ET and in situ structural biology at the Institute of Biophysics in Beijing. Keep connected. Stay tuned.

Truly honored that our work was highlighted as one of many applications where #Alphafold has had an enormous impact. As someone who quickly became obsessed with Alphafold during the early days, it’s particularly special to get recognized by scientists whom I greatly admire.

@rhuttenhain Beautiful logo

Hello world! After my lab has been operating in "stealth mode" for 1.5 years, I am excited to announce that we finally have a website: huttenhainlab.com By the way I'm also hiring and looking for a postdoc with proteomics experience: postdocs.stanford.edu/prospective/op… #TeamMassSpec

Make publication ready figures from your #AlphaFold PAE files. Works on multimer and AlphaFold 3 files. Customize colors and export as an SVG for editing in illustrator! thecodingbiologist.com/tools/pae.html

.@theliulab @MRuwolt @diogobor @milanzord @absea_bio @Julia_RtaAn introduce a XL-MS standard based on human proteins or protein fragments produced in E. coli. The paper also introduces Scout, a search engine for XL-MS studies with cleavable cross-linkers. nature.com/articles/s4159…