Genes & Development

🚨 NEW ISSUE ALERT!!! 🚨 New Research articles and Outlook online now at Genes & Development. Also in this issue, the first in a series of Review articles on Cancer Metabolism. Click on the link to learn more: ➡️ genesdev.cshlp.org/content/40/5-6…

🆕 ADVANCE ONLINE 🆕 RESEARCH COMMUNICATION: Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer By Garcia-Martinez et al. and Lluis Morey ➡️ genesdev.cshlp.org/content/early/… @lluismorey @SylvesterCancer @umiamimedicine #chromatin #transcription

📽️ G&D Tapes 📽️ G&D Author, Chiara Nicoletti, tells us about how MYOD’s context-dependent role as a transcriptional repressor during skeletal muscle development. Learn more here: ➡️ genesdev.cshlp.org/content/39/21-… @C_N1c0L

OUTLOOK: Making order from disorder in the nucleolus By Susan J. Baserga ➡️ genesdev.cshlp.org/content/40/5-6… Also read: ➡️ genesdev.cshlp.org/content/40/5-6… @susanbaserga #ribonucleoproteins #biocondensates #Cajalbodies #proteininteractions

Register now for On Demand Access to @KeystoneSymp RNA Modifications: Bridging Biological Function and Therapeutic Potential, this March to explore emerging research! #KSRNAMod26 For more info: ➡️ hubs.la/Q03-NnlC0

📽 G&D Tapes 📽 G&D Author, Christina McNerney, tells us about their new study in #genesdev showing how enzyme DIO3 coordinates photoreceptor development. Read the full story here: ➡️ genesdev.cshlp.org/content/40/1-2… @BobbyJEyeGuy @JohnsHopkins #photoreceptor #hormone #neurons

🎙️ G&D Voices: Author Robert J. Johnston Jr. 🎙️ At G&D, we publish rigorous, mechanism-focussed research while embracing cutting-edge model systems. Here’s what @BobbyJEyeGuy had to say about publishing in G&D. Learn more here: ➡️ genesdev.cshlp.org

📽️ G&D Tapes 📽️ G&D Author, Ayokunle Araoyinbo, tells us about the compartment-specific roles of Mei2 in yeast RNA regulation and zygotic development. In this issue of #genesdev: ➡️ genesdev.cshlp.org/content/40/5-6… @araoyinbo_ayo @AleksVjestica #RNA #translation #yeast #mitosis

RESEARCH PAPER: Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development By Araoyinbo et al., and Aleksandar Vještica ➡️ genesdev.cshlp.org/content/40/5-6… @araoyinbo_ayo @AleksVjestica #translation #yeast

RESEARCH PAPER: Retrotransposon activation during spermatogenesis achieves massive ecDNA biogenesis but rare integration By Tracy, Chen and ZZ Zhao Zhang ➡️ genesdev.cshlp.org/content/40/5-6… @zz_zhaozhang @DukeU #retrotransposon #Drosophila #spermatogenesis #genomestability #onthecover

RESEARCH PAPER: PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans By Walker et al., and Oliver Hobert ➡️ genesdev.cshlp.org/content/40/5-6… @Columbia @Columbia_Bio @hhmi_science #transcriptionfactor #Celegans #neuron #gut

Researchers in the former #AllisLab discovered that removing a specific region within a protein complex that regulates cell differentiation halts certain types of #cancer, including breast, prostate, blood, and skin cancers. @GenesDev rockefeller.edu/news/39158-thi…

RESEARCH PAPER: Independent control of neurogenesis and dorsoventral patterning by NKX2-2 By Jang et al., and Hynek Wichterle ➡️ genesdev.cshlp.org/content/40/5-6… @Columbia #transcriptionfactor #motorneuron #neurogenesis #spinalpatterning #Tinman

G&D Editor, Eric Sawey, is attending #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery in Breckenridge! #KSDiabetes26 @KeystoneSymp ➡️ hubs.la/Q03X7Ckz0 To share your work with us or learn about the journal — stop by or reach out at sawey@cshl.edu

RESEARCH PAPER: Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli By Meznad et al., and U. Thomas Meier ➡️ genesdev.cshlp.org/content/40/5-6… @EinsteinMed #Cajalbodies #ribonucleoprotein #biocondensate

📽️ G&D Tapes 📽️ G&D Author, Tuo Zhang, tells us about their new study in #genesdev showing how embryonic stem cells can attain a diapause-like state, and maintain their pluripotency and metabolic dormancy. Read the full story here: ➡️ genesdev.cshlp.org/content/40/5-6… @RockefellerUniv

RESEARCH PAPER: Transcriptional derepression of negative regulators of MAP kinase supports maintenance of diapause ES cells in the pluripotent state By Zhang et al., and Alexander Tarakhovsky ➡️ genesdev.cshlp.org/content/40/5-6… @RockefellerUniv #embryo #stemcell #diapause

RESEARCH PAPER: Combinatorial use of VHL and KEAP1 PROTACs reveals unexpected synergy and hook effect relief By Islam et al., and Luca Busino ➡️ genesdev.cshlp.org/content/40/5-6… @businolab @PennMedicine #PROTAC #KRAS #cancer #cancertherapy

CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer By Chrysanthi Moschandrea and Christian Frezza ➡️ genesdev.cshlp.org/content/40/5-6… @FrezzaLab @moschandrea @CECAD_ @UniCologne #cancermetabolism #tumormicroenvironment

G&D Editor, Samantha Cyrill, is attending RNA Modifications: Bridging Biological Function & Therapeutic Potential next week in Keystone! #KSRNAMod26 @KeystoneSymp Happy to chat about your work and the journal. Stop by or reach out at cyrill@cshl.edu ➡️ hubs.la/Q03-NnlC0