The Gu Lab

Now online! Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling dlvr.it/TM00Ph

Ever wonder who your cells are talking to? Now you can find out. Plasmids to perform the non-invasive gap junction tracing described in our recent Cell study are now available from Addgene! You can find them here: addgene.org/browse/article…

We’re excited to share our recent study published in @CellCellPress! In this work, we show that brain endothelial cells, connected by gap junctions, form a signaling highway to enable fast, long-range arterial vasodilation in neurovascular coupling. cell.com/cell/fulltext/…

New paper out in @NatureNeuro! nature.com/articles/s4159…

Congratulations to our newly minted Dr. Hannah Zucker!

Researchers Uncover Signal Needed for Blood-Brain Barrier HMS News article on new research from @SeanMegason, @gulabneuro, Allon M. Klein, and colleagues, first author @NatashaOBrown1 hms.harvard.edu/news/researche…

Out in press! With @AndyShih_Lab @Rconstantino @Mishra_CBF_Lab @Mishra_CBF_Lab @SusanneVanVeluw @Rconstantino spr.ly/6012OzV64

Humbled to participate in this scientific statement - I learned so much! The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the AHA/ASA tinyurl.com/3er68bh5

A new scientific statement examines the neurovasculome, shedding light on the relationship between the brain & its vessels and its roles in cognitive function. ✍️ @costantinoiade1 @GuLabNeuro @Mishra_CBF_Lab @MisraMD @SusanneVanVeluw 📍 @StrokeAHA_ASA: spr.ly/6012OzV64

Happy #FluorescenceFriday Image by @urs_langen, @GuLabNeuro of astrocytes (green, GFAP) in median eminence in touch with blood vessels (red, CD31) Image was acquired on a @LeicaMicro #SP8 confocal and processed using @ImarisSoftware

#FluorescenceFriday image by @urs_langen, @GuLabNeuro @harvardmed - red blood cells (green) in brain capillary (red) Image was acquired on a @LeicaMicro #SP8 confocal and processed using @ImarisSoftware

#microscopymonday image by @xjdumaine, @GuLabNeuro using our #VS120 slide scanner Here is the mouse choroid plexus, a structure in the brain ventricles that produces a clear fluid called CSF that helps to protect the brain and clear waste from it. The choroid plexus consists...

New lab photo + behind the scenes 📸

Farewell happy hour yesterday for our lab manager Chris - we’ll miss you! + congrats to our former postdoc, Swathi, and Chris for their recent paper🎉

We had a lot of fun writing this @NeuroCellPress N&V in Neuron on exciting new story from @GuLabNeuro. identifying a new way for pericytes to suppress BBB transcytosis. Open access @NeuroCellPress authors.elsevier.com/a/1f5cb3BtfH1Y…

@wenbin_tan It doesn’t efficiently transduce ECs in most peripheral organs

@GuLabNeuro Very Exciting! Dr Gu, does it work for ECs from other organs?

Plasmids to generate AAV-BI30, our vector that can specifically manipulate CNS endothelial cells, can be found on Addgene: addgene.org/browse/article…

@RuiBenedito_ Not yet!

@GuLabNeuro This is great...any other AAVs for other organ ECs or pericytes/SMCs ?

Technical Report| @gulabneuro @DevermanLab identify an #AAV variant (AAV-BI30) with high specificity and efficacy for transduction of #endothelial cells across the #CentralNervousSystem. @broadinstitute nature.com/articles/s4416… 👉rdcu.be/cLmoT