Gupta Lab

The first evidence of in vivo SARS-CoV-2 escape from antibodies: emergent Spike deletion H69/V70 and D796H mutation in a convalescent plasma (CP) treated patient. These mutations conferred reduced susceptibility to the CP and sera from multiple donors. medrxiv.org/content/10.110…

We love it when Lister community members team up 😍 Here, #ListerFellows Ravi Gupta @GuptaR_lab and James Thaventhiran @Thav_Lab look at pandemics and their prevention from different angles. Fabulous to break down disciplinary boundaries

Amazing thread from @LongDesertTrain ! We are learning more about persistence of viruses through careful work in labs around the world. COVID-19 work is critical to gain knowledge ; we have new paradigms for ‘respiratory’ virus persistence @hkjcghi @MedCambridge @AHRI_News

Tuberculosis has been with us for centuries and remains the deadliest infectious killer. At #CITIID @The_MRC LMB, Lalita Ramakrishnan works to understand TB at its roots and tackle drug tolerance & resistance to #EndTB. 🔗buff.ly/hmRgcyK @Cambridge_Uni #WorldTBDay @who

Until now, the broad pattern of SARS-2 evolution has been: 1) Emergence of a saltation variant originating in a chronic infection 2) Rapid growth/global dominance & a variant-driven wave of infection—especially if it emerges in late fall/winter (BA.1, XBB.1.5, JN.1). 2/

🏅Gold Medal at Geneva Inventions! Congrats to Prof Leo Poon Lit‑man @world_epidemic , Co‑Director of @hkjcghi, and his team at @hkumed for a breakthrough intranasal broad‑spectrum coronavirus vaccine that boosts mucosal immunity & blocks transmission. #GlobalHealth

Fantastic evening at the @cambridgesciencefestival alongside ⁦@Thav_Lab⁩ and @Suzanna Rihn speaking to our community about pandemics from pathogen and immunology perspectives. very poignant given my new role as co-director of ⁦@hkjcghi⁩ ⁦@MedCambridge⁩

Join us at @Cambridge_Fest to hear from #CITIID scientists @GuptaR_lab, @Lab_Rihn_th & @Thav_Lab from @MRC_TU 📢 Preparing for the Next Pandemic 🗓️ Tuesday 17 March, 6-7pm 📍 Jeffrey Cheah Biomedical Centre, @CamBioCampus 🔗 Book your place here: bit.ly/46a9elm

Dear students in the UK, if you haven't had your teenage meningitis vaccine or aren't sure if you have had it, PLEASE arrange with your GP to get vaccinated nhs.uk/vaccinations/m… It helps prevent tragic deaths like those that have occured recently in Kent.

Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges | New England Journal of Medicine nejm.org/doi/10.1056/NE…

Terrific meeting Darren Martin - our key genomics partner on Covid-19 projects. Flavour of the month is intrahost recombination and we have some cool stories in the pipeline. Also wish key collaborator and all round star ⁦@LongDesertTrain⁩ could be here ⁦@hkjcghi⁩

Big thank you to @FrankTanser for our meeting at stellenbosch uni and for showing me the Centre for Advanced Studies fellows program funded by Wallenberg. Academics come to spend time here thinking in a serene environment of gardens and of course the western cape climate.

Great to see old friend and ⁦@AHRI_News⁩ colleague Jackson ⁦@mohlopheni⁩ at his new home ⁦@StellenboschUni⁩ - talked infection and immunity collaborations at global scale ⁦@hkjcghi⁩ ⁦@MedCambridge⁩

His name was Satyendra Nath Bose. In the 1920s, he sent a paper to Albert Einstein that would quietly reshape physics. Einstein was impressed enough to translate it into German himself and help publish it. From that collaboration came a new category of particles now called bosons, named after Bose. Bosons include particles that carry fundamental forces and even the famous Higgs boson discovered nearly a century later. These particles do not behave like the matter building blocks we are used to. They can share the same state and act together in remarkable ways. That unusual behavior allows phenomena like lasers and superconductivity to exist. Yet outside scientific circles, Bose remains almost invisible. His contribution was foundational, but he did not chase fame. He worked as a professor, taught students, and continued exploring ideas with quiet dedication. History often shines its brightest spotlight on a few towering figures, leaving others in the shadows. There is something humbling about that. A man whose name labels half the fundamental particles in nature is rarely mentioned in everyday conversations. His work helped unlock some of the deepest laws of reality, yet he never became a household name. The story of Bose reminds us that influence and recognition are not always equal. Some of the most powerful contributions happen quietly. Behind every famous breakthrough, there are often brilliant minds whose names we barely remember. And sometimes, the universe itself carries their legacy forward, even if the world does not.

🔍New study reveals silent mpox circulation in Nigeria Research led by Prof Ravi Gupta @GuptaR_lab, Co‑Director of HKJCGHI and The Hong Kong Jockey Club Professor of Global Health @Cambridge_Uni, published in @NatureComms. Read more: lnkd.in/duDFv8Vv

The Salary Negotiation That Taught Me Everything In 2025 Candidate: "I need 100,000 per month." HR : Our budget is 60,000 per month. Boss: "Pass. Too expensive." HR almost moved on. Almost. But HR asked one question: "What would make 60,000 not work for you?" Candidate : "Honestly? Nothing. I have loans, rent just went up, and I'm tired of being underpaid because I'm 'still learning.' I know my worth now." HR went back to his boss. Showed them the cost of leaving the role open another 3 months. The lost productivity. The team burnout. The recruiter fees if we went external. It was over 50,000. The boss accepted. Here's the part that still gives the HR chills: Six months later, she told HR she had another offer for 130,000 per month but turned it down because they were the only company that fought FOR her, not AGAINST her. Candidates remember who believed in them. They remember who negotiated IN GOOD FAITH versus who played games. Stop treating salary negotiations like a battle to win. Start treating them like the first test of your company culture. Because if you can't advocate for someone BEFORE they join, why would they believe you'll advocate for them AFTER?

BA.3.2 emerged in Nov 2024 after ~3 years of intrahost evolution with >50 new spike AA muts, but since then, it's changed very little. Could the drug molnupiravir (MOV) galvanize BA.3.2 into pursuing new evolutionary paths? A new 89-mut MOV BA.3.2 seq suggests it could. 1/11

We simulated how an H5N1 outbreak might unfold in humans and possible early interventions, using BharatSim. BBC coverage of our work is here. bbc.com/news/articles/…

Very timely publication from the U.K. Chief medical officer. Whilst we are busy trying to forget about infections in the COVID-19 aftermath, infectious diseases have not forgotten about us! gov.uk/government/pub…

Latest insight from @GuptaR_lab on how this discovery upends our understanding of what’s required for curing HIV👇

Impressive number of Lister community members in @Clarivate's Highly Cited Researchers 2025. Our first shoutout to current #ListerFellows 🥇 Marco di Antonio @DiAntonioLAB1 🥇 Ravi Gupta @GuptaR_lab Congrats on your highly influential research 👏 clarivate.com/highly-cited-r…