The Harris Lab

So excited to share our latest work with Sarat Chandarlapaty, @antoniomarraMD, Andrea Gazzo @MSKCancerCenter out today in @NatureGenet! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. 🧵 1/ nature.com/articles/s4158…

Great representation at the 1st Annual Biochemistry Research Day at UTSA.

Carcinogens in tobacco smoke leave the genome vulnerable to deamination by viral restriction factor APOBEC3B. This new pattern of mutations known as “Didyma” can help delineate the origins a different cancers. Check out the full Pre-Print here: biorxiv.org/content/10.110…

🚨 APOBEC3B (A3B) is a major source of🧬mutation in cancer The active site is like Teflon (not much binds) BUT @Ozlem__Dmr discovered a druggable allosteric site 👀 Experiments by @DanHarki @_ChemKat @HarrisLabUTHSA 💪 biorxiv.org/content/10.110…

What a great way to start the day. This superb work from the Pillai lab, driven by Prajwal Boddu and a little help from us @bdelapenavalos is finally in print @MolecularCell Highlight: SF3B1 oncogenic mutations reduce RNAPII gene-body elongation rate. sciencedirect.com/science/articl…

We thank our program committee for creating a great #SABCS24 lineup. @VKaklamani @CarlosArteagaMD @BalkoLab @tperrybrown @heide_ford @HarrisLabUTHSA @TariKingMD @lab_kok @Adrianvlee @itsnot_pink @hmcarthur @dapattmd @c_sotiriou @atanmdlci @NeilVasan @adawaksmd @awolff @AACR_CEO

📣 Hot off the press! @NAR_Open Delighted to share our latest work! Thanks to all collaborators and contributors.

Excited to share that our paper was officially published in Molecular Cancer!👇 Read more about EYA4 and its role in promoting breast cancer progression and metastasis here: rdcu.be/dnzkx A big thanks to @dray_lab and fantastic collaborators @RTropee and @DuijfLab.

Congratulations to Arad and Sofia for defending their respective PhD theses! This marks the official sunset of the Minnesota Harris Lab. We wish them the very best in their next steps!

Happy to share our last findings on HCMV evasion of APOBEC3 restriction!🤩 Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism | Journal of Virology journals.asm.org/doi/10.1128/jv…

Big news from Midwest AViDD Center featuring @elisafanunza @GuptaYogeshTX and Shaun Olsen

Don't miss the great work by members of our virus team this year at ASV! Elisa is sharing her poster at 8:30 PM at P22-23 and Ashley's work can be found at P10-8. #ASV2023 #LoveVirology

Check out the latest publication from PhD student Jordan Naumann! She utilizes the hydrodynamic FAH delivery system to show "DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo" mdpi.com/2312926 #mdpiijms via @IJMS_MDPI

Congratulations to Dr. Amanda Rieffer for a successful PhD thesis defense last Friday! We wish her the very best in all future endeavors!

Beautiful story by our very own @JordanBeckerPhD and student @Ashley_Auerbach Congratulations on the cool discovery!

Don't miss the latest work from our PhD student Arad, his gain-of-signal assay is prominently featured in @ScienceAdvances science.org/doi/10.1126/sc…

Congrats to our student Cameron Durfee and his preprint on #bioRxiv He demonstrates human APOBEC3B can drive tumor formation in vivo. Check out this beautiful story below!

The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to the present day. elifesciences.org/articles/83893…

My 1st first-author manuscript is out in @eLife! This project started back in 2019 with the question “what makes a viral protein evolve a new function?” A thread: doi.org/10.7554/eLife.…

Excited that my first co-first author paper was officially published today on mSphere! Read more about APOBEC3B nuclear localization here: journals.asm.org/doi/10.1128/ms…