Dave Hughes

Final Version of our article on UBR-box E3 ubiquitin ligases, protein synthesis and skeletal muscle size now online 🚨 | @AJPCellPhys @CraigAGoodman1 @DrAdamPSharples | journals.physiology.org/doi/full/10.11… Review in this area recently published here: journals.lww.com/acsm-essr/full… #Myotwitter

Super proud to share the first original research paper from my new lab: "Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans" cell.com/cell-reports-m…

Humans with function-disrupting variants in the myostatin gene (MSTN) have increased skeletal muscle mass and strength, and less adiposity nature.com/articles/s4146…

We are excited to announce the dates for the 2027 Advances is Skeletal Muscle Biology Conference will be March 17-19, 2027! Mark your calendars and plan to join us in Gainesville, FL. on the University of Florida Campus. We look forward to seeing you!

The Lab had a great time contributing to this event and giving back to the wider community 👏🏼👏🏼

Human plasma extracellular vesicles as an exercise mimetic to preserve skeletal muscle plasticity during disuse nature.com/articles/s4152…

Our new study is now published in Advanced Science We show that skeletal muscle retains a molecular memory of disuse Young muscle shows transcriptional resilience Aged muscle shows exaggerated vulnerability advanced.onlinelibrary.wiley.com/doi/10.1002/ad… @nih_sognsvann @nih_physicperf

Now recruiting an experienced Post‑Doc in Skeletal Muscle Molecular Physiology @nih_sognsvann Oslo, Norway Join our multi‑omics EMMA project on mitochondrial epigenetic memory in human muscle aging. 4‑year position Start May 2026 Apply via Jobbnorge: jobbnorge.no/en/available-j…

Thrilled to share our new @ScienceAdvances paper where we provide evidence that mechanical stimuli drive skeletal muscle growth through TWO distinct mechanisms—and use BONCAT to visualize where the growth occurs. Take a look: science.org/doi/10.1126/sc…

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism | Science Advances science.org/doi/10.1126/sc…

Excited to share our new preprint! @NolanJHoffman Subcellular proteomic profiling of human skeletal muscle reveals exercise-induced coordinated and compartment-specific protein remodelling 🧬 We identify novel translational exercise regulator RACK1 biorxiv.org/content/10.648…

New #SkeletalMuscle paper: The transcriptomic signature of age and sex is not conserved in human primary myotubes. tinyurl.com/2jf79e87

@Shenhav_Lab You’re welcome Shenhav. I always look forward to seeing future contributions to the field from your lab 👏🏼👏🏼👏🏼

@HughesDC_Muscle Thank you very much Dave:)

Mechanisms of protein degradation in atrophying muscles: what have we learned during the past decade? Great new review from ⁦@Shenhav_Lab |⁩ #myotwitter 💪 jbc.org/article/S0021-…

Congrats to all our PIs who received grants in 2025! After the year of uncertainty for funding research, these are all big wins for our scientists! 👏🧬🏆

Mechanisms of Skeletal Muscle Mass Regulation and Muscle Memory onlinelibrary.wiley.com/doi/10.1111/ap…

Parkin overexpression attenuates muscle atrophy and improves mitochondrial bioenergetics but not histological features of Duchenne muscular dystrophy in mice | Scientific Reports nature.com/articles/s4159…

Nice feature in @TheAtlantic by @bonnietsui Our lab’s latest study reveals that skeletal muscle doesn’t just remember growth-it also remembers inactivity. Repeated disuse leaves a molecular imprint that shapes future responses. theatlantic.com/health/2026/01…

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging? onlinelibrary.wiley.com/doi/10.1111/ac…

Protein:protein interactions are dynamic so how do we quantify and discover changes in native tissues? Our new study uses qXL-MS and PCP-MS to study dynamic remodeling of interactions following skeletal muscle insulin resistance. biorxiv.org/content/10.648… #myotwitter #proteomics

Congrats to the CMR's @duttmri, @Ben_Leo_Parker and Team for their new Nature Comms paper "Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator" @UniMelbMDHS @UniMelb nature.com/articles/s4146…