Frank Paul Mora

Feeding microbes to feed the Gut: inulin reprograms intestinal epithelial metabolism and proliferation through HIF1α 👇 #d1e292" target="_blank" rel="nofollow noopener">tandfonline.com/doi/full/10.10…

A microbiota-host axis mediates prostaglandin sensitivity: Lactobacillus crispatus as a biomarker and regulator of human labor induction 👇 nature.com/articles/s4152…

The hidden drivers of Alzheimer’s are not in your brain New science shows Alzheimer’s may be shaped by an organ-brain axis, where the gut, lung, liver, and bladder influence brain inflammation. 1. In Alzheimer’s, immune changes outside the brain may help drive: - chronic neuroinflammation - blood-brain barrier breakdown - harmful microglia and astrocyte activation 2. The gut-brain axis is especially important: - Healthy gut microbes support anti-inflammatory immune balance - Gut dysbiosis can shift immunity toward Th17-driven inflammation - This may worsen brain immune activation and neuronal damage 3. Key protective gut metabolites like SCFAs help: - strengthen the blood-brain barrier - support regulatory T cells - maintain healthy microglia function 4. Other microbial signals, such as AhR-related pathways, may also help suppress excessive inflammation in both the gut and brain. The big takeaway: Alzheimer’s progression may be influenced not only by amyloid and tau, but also by system-wide immune dysfunction. The future of Alzheimer’s treatment may not stop at the brain, it may start with the body.

Researchers show that endogenous VEGF signaling safeguards human primed pluripotency, maintaining stem cell self-renewal and preventing differentiation into trophoblast-like cells. 📕 @NatureComms 🔖 go.nature.com/4smiH1J

@chydorina @loscharlos Hi! We are slated for first-in-human mitochondrial transplantation this year. AND my announcement about the MMT therapy was 100% home-based. I’m excited to provide all sorts of options to all patients. My role is to build functional, actionable toolkits, not to sell magic bullets

Medellín, Colombia dropped its city's warming temps by a whopping 4 degrees Fahrenheit. How? They created "green corridors" of trees and plants throughout the built city. It cost $6.50 per resident, and will save the city millions of dollars each year. We need more of this!

New Research: Spinocerebellar ataxia with mixed tremor and hippocampal atrophy: case report and literature review frontiersin.org/articles/10.33… #FrontiersIn #Neuroscience

Mitochondria in a capsule? Researchers demonstrate mitochondrial transplantation (via erythrocyte membrane encapsulation), rescuing mitochondrial defects in patient-derived cells & #Parkinsons mouse model cell.com/cell/abstract/…

@HatragyiSafarne Modest iron deficiency can actually promote Treg expansion and improve outcomes in autoimmune models like lupus.

The crosstalk between iron metabolism and immune tolerance in autoimmunity 👇 link.springer.com/article/10.100…

Finally received my copy of 'After Covid', a book by @business senior editor @jwgale. Thank you, Jason, for giving scientists like me the space to tell our story without political bias. #COVID and #LongCovid also changed my life. You can get a copy here: press.jhu.edu/books/title/53…

Democrats are forcing a vote to fully fund TSA immediately. Senate Republicans should join us and vote yes to end this chaos. washingtonpost.com/travel/2026/03…

@HatragyiSafarne The treatment restored the Th2/Th17 immune balance, which is often disrupted in allergic conditions.

Human Milk Oligosaccharide Synbiotic Alleviates Food Allergy in Mice by Modulating Gut Microbiota and Increasing Indole-3-lactic Acid Levels 👇 pubmed.ncbi.nlm.nih.gov/41859771/

@AARustom There may be no real time but what we call "time" can be measured.

You are not becoming who you will be. You are aligning with who you already are. A new essay on block universe physics, neural networks, and the strange possibility that the self at the end of your path already exists. Read here: aarustom.substack.com/p/you-already-…

Senolytic treatment induces oligodendrocyte dysfunction and demyelination in the corpus callosum pnas.org/doi/abs/10.107…

Lab-grown oesophagus restores pigs’ ability to swallow @nature nature.com/articles/d4158… @NatureBiotech @ucl 🇬🇧🇮🇹 nature.com/articles/s4158…

Lactobacillus acidophilus combined with Pediococcus acidilactici ameliorates colitis 👇 pubmed.ncbi.nlm.nih.gov/41859447/

Hyperinnervation inhibits organ-level regeneration in mammalian skin: Cell cell.com/cell/fulltext/…

Spatially targeted inhibitory rhythms differentially affect neuronal integration doi.org/10.7554/eLife.… #neuroscience