MCRI Jaffe Lab

New from the @IrisJaffeLab! 🙌 Ponatinib, a potent anticancer therapy, activates #EndothelialCells and platelets, driving plaque inflammation and death from MI and stroke in mice, mirroring clinical cardiotoxicities in patients with cancer. | @CircAHA 🔗 bit.ly/4mrUhAz

Tufts Medical Center-Led Study Identifies Safer Path Forward for Cancer Patients at Risk of Heart Disease | ⁦@TuftsMedicalCtr⁩ ⁦@TuftsMedSchool⁩ ⁦@TuftsMCResearch⁩ tuftsmedicine.org/about-us/news/…

Congratulations Tufts MD-PhD student Alec Stepanian and ⁦@TuftsMedicalCtr⁩ Molecular Cardiology research Institute team. ⁦@TuftsMedSchool⁩ ⁦@TuftsMCResearch⁩ pubmed.ncbi.nlm.nih.gov/40762051/

Members of our Molecular Cardiology Research Institute volunteered with @communityserv yesterday to prep medically tailored meals for people with heart failure, diabetes, kidney disease and HIV. Proud to support patients beyond the lab. #TuftsMedicine @irisjaffelab

Happening now at #AACR25 @TuftsMedicine + @TuftsMedSchool's @IrisJaffeLab presents Cardio-Oncology: A Novel Platform for Investigation. Room E353C 10:15am - 11:45am CST. #CancerResearchSavesLives #TuftsMedicine

The talk describes a new mechanism discovered in @IrisJaffeLab showing how drugs that treat certain leukemias also cause heart attacks + strokes in cancer survivors. This research sets the stage for new treatments to protect leukemia survivors from CV side effects #AACR25

Congratulations Alec Stepanian on a fantastic presentation. Alec was one of only 10 MD/PhD students across the country chosen to speak at the ASCI/AAP meeting in Chicago. @TuftsMedSchool @TuftsMedicalCtr @hboucher3

Congratulations Alec Stepanian on a fantastic presentation. Alec was one of only 10 MD/PhD students across the country chosen to speak at the ASCI/AAP meeting in Chicago. ⁦@TuftsMedSchool⁩ ⁦@TuftsMedicalCtr⁩ ⁦@hboucher3⁩

The definition of bridging the #bench-to-bedside divide: Iris Jaffe is the inaugural director of the Tufts University–Tufts Medicine Research Enterprise #transformative @TuftsUniversity @TuftsMedicine @IrisJaffeLab ow.ly/hVF450VFGcq

Congratulations Lauren Biwer on receiving the Early Career Investigator in Atherosclerosis Award at Vascular Discovery. ⁦⁦@TuftsMedicine⁩ ⁦@YaleMed⁩

@yenelizabethmd @PerinatResSoc @mypsanz @tuftsctsi @TuftsMCResearch @womenandinfants @SRWesolowski @LJossMoore @ibuhimschi Congrats Liz

@TuftsMedicalCtr @TuftsMedSchool @w_sarraj_ @ErikaWernerMD @hboucher3 Thank you everyone. I am so honored.

Congratulations to Iris Jaffe, MD, PhD (@irisjaffelab), on receiving the 2025 Barbarajean Magnani Award, recognizing outstanding women’s leadership in medicine and science. #TuftsWiMS @TuftsMedSchool #TuftsMedicine @w_sarraj_ @ErikaWernerMD @hboucher3

#TuftsMedicine’s @NavinKapur4 presents at #THT2025 on Safety and Efficacy of the preCARDIA System to Mechanically Reduce Cardiac Preload for Acutely Decompensated Heart Failure. 📍 Ensemble A-B | Level 2 ⏰ 7:55 – 9:12 am #Cardiology @IrisJaffeLab

Congratulations Alec Stepanian for a fantastic presentation and for winning the Jonathan Epstein Scholar award at the 227th ICC meeting. ⁦@TuftsMedicalCtr⁩ ⁦@TuftsMedSchool⁩ ⁦@TuftsMCResearch⁩

Our amazing #bircwh scholars at the annual meeting @NIH_ORWH @ErikaWernerMD @IrisJaffeLab @TuftsMedSchool @TuftsNutrition

Congratulations Casey Turner on her F32 grant from the NIH and her mentor Jennifer DuPont. @TuftsMedicalCtr @TuftsMCResearch

Congratulations Nicole Wolter, Tufts MD PhD student for her AHA early career travel award. ⁦@TuftsMedSchool⁩ ⁦@hboucher3⁩

Fantastic talk from Alec Stepanian Tufts MD PhD student at AHA Vascular Discovery Conference in Chicago showing his innovative mechanism for arterial thrombosis in cancer patients treated with Ponatinib. ⁦@TuftsMedicalCtr⁩ ⁦@TuftsMedSchool⁩ ⁦⁦@MTChinMDPhD⁩ ⁦

Tufts MD PhD student Nicole Wolter gave a spectacular talk at the AHA Vascular Discovery Conference in Chicago. I couldn’t be more proud. ⁦@TuftsMedicalCtr⁩ ⁦@TuftsMedSchool⁩ ⁦@TuftsMCResearch⁩ ⁦@hboucher3⁩ ⁦@MTChinMDPhD⁩