Jarosz Lab

@ElliotHershberg Congratulations :)

New hobby: urban rucking.

HUGE congrats to @clairebedbrook and @Ravi__Nath for exciting work on lifelong behavioral tracking in the killifish 🐟😎 Super cool that behavior can define discrete life stages and predict future lifespan!! Awesome collaboration with @scott_linderman and @KarlDeisseroth!

New work describes our efforts to achieve CRISPR editing of the mitochondrial genome. biorxiv.org/lookup/content… The CRISPR toolbox has revolutionized the study of nuclear DNA, but the mitochondrial genome (mtDNA) has remained out of reach, mainly because there are no known ways to deliver sgRNAs across both outer and inner mitochondrial membranes. Yet many organisms have evolved mechanisms to transport RNAs across their mitochondrial membranes. Trypanosomes, for example, do not encode any tRNAs in their mtDNA, and must import all of them from the cytosol to support intra-mitochondrial protein translation. We started with yeast. We engineered a strain that must repair a STOP codon in mtDNA (an arginine biosynthesis gene) to survive. After screening a library of sgRNA import sequences, we identified one that enables a small degree of functional CRISPR editing in mitochondria. Graduate student Sifei Yin obtained these exciting results several years ago, and spent the intervening time understanding how sgRNA import works, and how to make it better. Read the paper to learn what she uncovered!

We don't know the (phenotypic) consequences of most mutations. Good news, the proteome can help! And it predicts phenotypes in new environments. science.org/doi/10.1126/sc…

Our latest: Directly measuring how mutations control proteins is a window into adaptation (w/ @RalserLab). Natural variants dramatically reshape the proteome, often in unexpected ways. Remarkably, these latent genome-proteome connections can predict variants' future consequences. science.org/doi/10.1126/sc…

@Richard_She Many congratulations Richard!

I'm excited to share that I will be starting my lab at NTU Singapore. It is bittersweet to be moving halfway around the world. On one hand, I'm excited for a new adventure. I have spent my entire adult life chasing this dream, and it's finally happening. On the other hand, I still love America and believe in all of the good that it stands for. My parents moved here to give me the gift of the American Dream and I never thought I would experience what it's like to be an immigrant to a new country myself. I can only say that life has a way of offering blessings in disguise, and I’m grateful for this opportunity in every way.

@jacob_hanna Glad to hear you and those in your lab are safe — but so sorry to learn this devastating news

After being stuck in Hong Kong after ISSCR meeting unable to fly back home, I managed to get on a plane to London to stay with family.. only to learn now in the air that our institute was hit. My team is all safe which is what matters. My lab sustained serious blast damage but we shall overcome! #PeaceNow Thanks for all the emails and messages.

@JSheltzer Welcome to Stanford! Looking forward to connecting when you arrive

I’m thrilled to share that I’m joining the faculty at the Stanford University School of Medicine. My lab and I will be relocating to Stanford this summer!

@multicellgenome Will have to visit soon to learn more. Thanks for the constant inspiration!

😻 HUGE NEWS! We've done it! One of the "Magnificent 8" – key missing lineages for understanding animal origins – is ALIVE in our lab! Previously just DNA whispers, Maop 2 could now open a new chapter for research. 📖 We will soon formally "introduce" it to the scientific world. Watch our team’s excitement in the video! Massive thanks to @Luisjagago (isolation wizard!) & @beaplab_ibe (crucial throughout!). @IBE_Barcelona @the_prbb @CSICdivulga @CSIC @ERC_Research #AnimalOrigins #Biodiversity #holozoans #Magnificent8

It is finally out! I am incredibly proud to share that my work has officially been published in Cell @CellCellPress! This work was a product of years of dedication and countless hours of research in the labs of Joanna Wysocka and @JaroszLab @StanfordMed cell.com/cell/fulltext/…

What RNA polymerase gets up to in the genome and how mutations happen! Out in Nature today! Many thanks to many collaborators and congrats to 1st author Jingjing Liu! nature.com/articles/s4158….

Our perspective on Hsp90 as a global modifier of the genotype-phenotype-fitness map, along with its implications for evolution in nature and clinical settings, is now out in JMB. We review the existing literature, identify open questions, contextualize our recent findings on Hsp90, and present new analyses that expand the current understanding of its evolutionary impact. Congrats to @jaguilarrod and Chris Jakobson. Check it out here: sciencedirect.com/science/articl…

Excited to share a fantastic collaboration w/ @RalserLab: Linking natural genetic variants to effects on the proteome revealed how mutations drive rapid adaptation and forecast which were important in new environments! biorxiv.org/content/10.110…

@morris_lab @harvardmed @BrighamWomens Congratulations!! Will be sure to pass by and celebrate when you arrive!

Some exciting news to share! Our lab is relocating to @harvardmed Systems Biology and @BrighamWomens GI & Genetics this fall. We're actively recruiting talented postdocs to join our team. Please RT to spread the word.

@Caroline_Bartma Congratulations!

@ScienceyRosalie @BC_UCLA Congratulations Rosalie!

Thrilled to announce the Lawrence Lab will open its doors within UCLA Biological Chemistry @BC_UCLA in January 2025! I couldn’t be more excited!

@liyuping927 @biozentrum @NCCR_AntiResist @UniBasel_en @ElginKorkmazhan So happy for you! Many congratulations!!

I am thrilled to start my lab as an assistant professor @biozentrum & @NCCR_AntiResist of @UniBasel_en this fall. I will continue my research interest in bacteria & jumbophage interactions. Equally thrilled to be closer to our families after 10+ years.