Keane Lim

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Keane Lim

Keane Lim

@KeaneLim

Interested in psychiatric genetics & neuropsychology · Own views

IMH, Singapore เข้าร่วม Ağustos 2019
84 กำลังติดตาม27 ผู้ติดตาม
ทวีตที่ปักหมุด
Keane Lim
Keane Lim@KeaneLim·
Our new paper out in @SchizBulletin found & replicated 4 distinct cognitive profiles in schizophrenia. Subtypes consists of a “less impaired” subtype, two “intermediate cognitive impairment” subtypes differentiated by executive function, & “globally impaired” subtype.
Schizophrenia International Research Society@SIRSGlobal

Managing heterogeneity of #schizophrenia using cognitive subtyping: A latent profile analysis using data from 762 patients reveals 4 distinct profiles that were stable across time and were associated with clinical outcomes. doi.org/10.1093/schbul… @SchizBulletin @KeaneLim

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Keane Lim
Keane Lim@KeaneLim·
Thank you all participants & co-authors (Jason Smucny, Deanna Barch, @maxzylam, Richard Keefe, Jimmy Lee) for being a part of this work!
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Keane Lim
Keane Lim@KeaneLim·
This 4-profile cognitive solution showed stability across time. CFA revealed cognitive profiles are better explained by distinct profiles rather than a severity continuum.
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Keane Lim
Keane Lim@KeaneLim·
Our new paper out in @SchizBulletin found & replicated 4 distinct cognitive profiles in schizophrenia. Subtypes consists of a “less impaired” subtype, two “intermediate cognitive impairment” subtypes differentiated by executive function, & “globally impaired” subtype.
Schizophrenia International Research Society@SIRSGlobal

Managing heterogeneity of #schizophrenia using cognitive subtyping: A latent profile analysis using data from 762 patients reveals 4 distinct profiles that were stable across time and were associated with clinical outcomes. doi.org/10.1093/schbul… @SchizBulletin @KeaneLim

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Keane Lim
Keane Lim@KeaneLim·
Lastly, thank you all participants & co-authors for being a part of this work!
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Keane Lim
Keane Lim@KeaneLim·
Caveats: The lack of association between our Asian UHR cohort with other psychiatric traits may be due to differing ancestry & sample size of the training & target datasets. Further studies are warranted for replication.
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Keane Lim
Keane Lim@KeaneLim·
"Unlike neurocognitive tasks that are less dependent on cultural specificities, social stimuli are often abstract or utilize words with meanings that are not fully equivalent across cultures" - Hajdúk et al in @SchizRes sciencedirect.com/science/articl…
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Keane Lim รีทวีตแล้ว
Toby Pillinger
Toby Pillinger@tobypill·
Our new @TheLancetPsych paper examines metabolic side effects of 18 antipsychotics in the treatment of schizophrenia: a network meta-analysis of 100 RCTs and over 25,000 patients. Here’s a tour of the paper, with some unexpected results… [thread] 1/n thelancet.com/journals/lanps…
Toby Pillinger tweet media
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Keane Lim
Keane Lim@KeaneLim·
Finally, we would like to thank all our participants who participated in this study! (8/8)
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Keane Lim
Keane Lim@KeaneLim·
Our findings partially replicated SCOPE's where BLERT & ER40 showed best psychometrics. However, its premature to exclude tasks with poor psychometrics for further evaluation as cultural modifications/adaptations may be required (7/8)
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Keane Lim
Keane Lim@KeaneLim·
Excited to share our new work on the psychometrics of social cognitive measures in an Asian schizophrenia sample. Huge thanks to Sara-Ann Lee, Amy Pinkham, @maxzylam , Jimmy Lee for this! Thread follows (1/8) sciencedirect.com/science/articl…
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