James A. Letts

What are respiratory supercomplexes (SCs) doing? Our collaboration with @Holab_DukeNUS shows that an extra large SC forms between complex I and complex III in a mouse model of complex III deficiency. SC-XL rescues the respiratory defect. sciencedirect.com/science/articl…

Stunning work from Kai Zhang lab!

Hello to animation tuesday! 😉 This 👇 animation is the outcome of the work I did for our publication of the human prohibitin complex. Moddeled a mitochondrion and animated one of my beloved flythroughs, et voilà 🥰 #Blender3D #SciComm #SciViz #SciArt #animation

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: doi.org/10.1101/2025.0…

#CryoSPARC v4.7 is out! 🚀  Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more! Full changelog: cryosparc.com/updates #cryoEM

The final version of our work on the in-cell architecture of the mitochondrial respiratory chain is now online in @ScienceMagazine 🎉 You can find the full story here science.org/doi/10.1126/sc… @luminous_lab did a wonderful job on the cover and animation👩‍🎨

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion. Learn more: scim.ag/4iT8mpD

Another wonderful collaboration with @alanbrownhms lab. The Zhang lab together with @PolinaLishko lab (co-first author @QingweiN) contribute the doublet microtubule structure from Crithidia fasciculata, a model organism that infects mosquitoes. science.org/doi/10.1126/sc…

Wonderful turn out at March for Science in Sacramento today! Biomedical research saves lives, promotes innovation, and pays for itself many times over!! It has been a bipartisan issue for decades and made the US truly great! Stand up for science! Support NIH!

Very proud to share our latest work on the ancient the Na+-pumping Rnf complex – now out in Nature Comms. Thank you Schuller & Müller Labs for great collaboration, and @KAWstiftelsen for generous funding nature.com/articles/s4146…

Beautiful animation of metabolic flux in the mitochondrial Kreb (TCA) cycle The three "CO2" coming off the cycle is how you lose weight: carbon from your material body coming off as gas you end up breathing out By @janetiwasa

Unveiling the structure of a photosynthetic catalyst that turns light into hydrogen fuel See a high-resolution view of a hybrid catalyst that combines platinum nanoparticles and protein complexes anl.gov/article/unveil… Explore in 3D at RCSB PDB: rcsb.org/structure/8vu3

science.org/doi/10.1126/sc… Just published! We uncovered a molecular machine that connects the cell's two major structural networks revealing how cells accomplish precise internal reorganization - a process disrupted in diseases ranging from cancer to multiple sclerosis.

Great review on mitochondrial lipids @KatsuFunai why is it critical for the outer and inner membranes to have different lipid composition? cell.com/cell-metabolis…

📢 Submissions are now open for the CellMap Segmentation Challenge. Build the best method for segmenting cellular organelles in vEM using our 289 annotated volumes, 40 organelle classes, and 22 diverse cell and tissue types. 🔗 janelia.org/news/the-compe…

We have an open Postdoc position! Join our lab in Gothenburg at the beautiful west coast of Sweden to work on an exciting project: nature.com/naturecareers/…

I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @MPIbp! 🍃❄️🔬 You can find the paper in open access in @NatureSMB nature.com/articles/s4159…

My home department @MmgUcd @ucdavisbiology @ucdavis is recruiting a faculty member (Associate or Full) in cancer research with a potential synergy w/ dept. members. Plz RT! recruit.ucdavis.edu/JPF06905

Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods "Engineer RuBisCo" And this paper takes us one step closer nature.com/articles/s4158…

Remember learning that #ribosomes are made of 1 large subunit RNA + 1 small subunit RNA? Well, some cells defy this rule, and the most extreme case is #Toxoplasma which makes its mitoribosome from >50 RNA pieces! Wanna know how? Read the next comments.

Interested in #Archaea, #MembraneProteins or #cryoEM? A #postdocposition in @NCN_PL funded project at @JagiellonskiUni awaits you! Join our structure-function research on respiratory supercomplexes of #thermoacidophiles. Details are here: tinyurl.com/sulfolobus3 Please RT