ทวีตที่ปักหมุด
Stop glamorizing the hustle and start glamorizing the mussel
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Jake Wintermute 🧬/acc
12.1K posts
Jake Wintermute 🧬/acc
@SynBio1
Synthetic Biologist - Foundry Theorist - stay humble biodesigners
Cambridge, MA เข้าร่วม Haziran 2014
404 กำลังติดตาม15.8K ผู้ติดตาม
@notadampaul I mean at least a personal island universe matters to one person
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This is the core problem of the next 5 years in the AI scientist era: infinite hypotheses about which nobody cares
Sayan@thesayannayak
At this rate everyone’s gonna have their own app and zero users.
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@SynBio1 Yes, but not because of what you think is the cause. It will be because humans like you become completely irrelevant.
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@heuristics I love it when math makes useful predictions that matter to people, even if those predictions don’t have “actual explanations” behind them
The problem I’m trying to articulate is that AI can generate infinite predictions that will never be noticed or matter in any way
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@SynBio1 it's a weird thing, natural science has more and more abandoned having actual explanations and are gravitating towards simply having math that makes predictions. Without any reasons for why it is like so.
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@Sandbar101 Ok I’ll tell my wife and son to stop caring about me
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@heuristics Can a hypothesis be “good” if nobody ever notices or cares about it?
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@SynBio1 If one is found that has equal explanatory power but is metaphysically simpler, it’s a good thing, no?
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@Sandbar101 If your goal is to do things nobody cares about then you will surely succeed
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@baym @OmicsOmicsBlog Citrus reticulata getting absolutely frame mogged by Citrus maxima
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Jake Wintermute 🧬/acc รีทวีตแล้ว
Shout out to the absolute legends who somehow packed 19 jokes into their conference talks as documented in this study about the use of humor on scientific talks
royalsocietypublishing.org/rspb/article/2…
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@MPrasad65824 “Does anyone care about this” is a question I take seriously
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@MPrasad65824 I’ve been doing freelance techbio marketing and yes my clients care
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@SynBio1 "This is the core problem of the next 5 years in the AI scientist era: infinite hypotheses about which nobody cares"
That sounds like a great hypothesis! Did you find out if anybody cares?
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Least insane Cell paper
Banana Oncology@Banana_Oncology
Ok this figure is pretty intimidating...
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@JoeMcAuliffe17 @ProfTomEllis This is the most AI-ready problem on the list though
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@ProfTomEllis @SynBio1 If you can’t get patent protection then your entire value proposition is at risk. Of course a drugs has to be safe and effective as well, but the reality is that drug development requires millions of investor dollars.
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Okay here's a game - you're making nanobody therapeutics. AI can help you optimise them, but you need to prioritise order of feature importance. What is your order?
Affinity
Specificity
Expressibility
Clinical toxicity
In vivo stability
Purified stability
Patentability
Other?
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@Koningsbruggen 80 billion dollars can buy a lot of "how"
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@SynBio1 How? Sequencing all the bird DNA and guessing which parts are dino?
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I genuinely, unironically, and in the most literal possible terms believe that we could have brought back the dinosaurs for 80 billion dollars
Polymarket@Polymarket
JUST IN: Meta announces they'll be shutting down the Metaverse, after pouring $80,000,000,000.00 into the project.
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@ImranSHaque Any useful lessons from that history? Comp bio tricks for pulling out interesting hypotheses from the pile?
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This is the experience that every computational scientist has had for decades, we're just bringing it to the masses.
Jake Wintermute 🧬/acc@SynBio1
This is the core problem of the next 5 years in the AI scientist era: infinite hypotheses about which nobody cares
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@malikules Rollercoaster is only fun when it's going down
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