CollegeBoundMama

@CraigBrockie Restore

1 in 10 Americans now has an autoimmune disease. Lupus. Crohn's. Hashimoto's. Type 1 diabetes. Multiple sclerosis. Rheumatoid arthritis. Your doctor will tell you it's genetic. Or bad luck. Or that your immune system just "turned on itself." Harvard researchers disagree. A pediatric gastroenterologist at Mass General (Dr. Alessio Fasano) spent 20 years tracking down the missing piece. What he found changed the conversation. Every autoimmune disease he studied shared the same three ingredients: - A specific environmental trigger - Genetic predisposition - A leaky gut Take any one of those away, and the disease doesn't start. The gut isn't just where food gets digested. It's a one-cell-thick wall - The only thing standing between your bloodstream and everything you eat, drink, and swallow. When that wall is tight, your immune system stays calm. When it's leaky, Undigested food particles and bacterial fragments slip through into your blood. Your immune system sees invaders and attacks. But the particles look a lot like your own tissue. Attack the gluten fragments → attack the thyroid (Hashimoto's) Attack the bacterial fragments → attack the joints (rheumatoid arthritis) Attack them over and over → attack the nerves (MS), the gut (Crohn's), the pancreas (Type 1) This is called molecular mimicry. Here's what people report when they heal the gut wall: Skin clearing up Brain fog clearing up Digestion finally working Joint pain fading within weeks Autoimmune flares slowing down Energy returning after years of fatigue The things that punch holes in the gut wall: Gluten (yes, even if you don't have celiac) Glyphosate on conventional crops NSAIDs (ibuprofen, aspirin) Ultra-processed food Chronic stress Antibiotics Poor sleep None of these are rare. Most people have all seven running on autopilot. I've been saying for 30 years: almost every chronic disease traces back to a broken gut. The science keeps catching up. The good news? Unlike your genes, the gut wall is something you can actually rebuild. Comment RESTORE and I'll send you a free guide on how to heal the gut and calm the immune system naturally. P.S. MUST Follow for me to DM you.

@Covid_institute What if you are too nauseous in the morning to drink water or eat?

5/6 What helps: 16 oz water with a quarter teaspoon of salt before your feet hit the floor. Five minutes of supine stretching. Light protein within 30 minutes. Blood volume expands, circulation starts without gravity, amino acids stabilize glucose without the cortisol hit.

The first hour out of bed sets the tone for the entire day in dysautonomia. Four things that worsen morning crashes, and three that help. If your worst hours land before 10 AM, the trigger is usually something you did in the first 30 minutes awake.

@markkaplan20 Thank you for building this. Do you have women doctors on your team? I didn’t see any on your website. If not, please consider adding women’s health experts. Women’s cardiovascular issues are different than men’s.

Mainstream medicine does not tell you this. Your pediatrician won't order genetic testing. Your cardiologist won't either. Neither will your primary care doctor. Insurance won't cover it because there's no billable code that ends in "give this patient a pill." Root-cause prevention doesn't make money. Lifetime drug prescriptions do.

"Heart disease runs in my family." Four words I heard my whole life. Four words millions of people say. They're describing their genes without knowing it. I ignored those words until they nearly killed me at 52. Then I did what nobody had ever told me to do. I tested my genes. What I found changed everything. For me and for my son David. 🧵

@markkaplan20 Thank you for this 🙏

Why we STILL have no FDA-approved therapies for #POTS and #dysautonomia: ❓ Where did we go wrong??? Here is MY take on WHY: 🧠 Labeling it as "complex, multi-systemic, multi-factorial." All true, but in reality -- it creates ambiguity, lack of focus, broad range of phenotypes and etiologies ➡️ Mechanistically, where do you even begin to develop targeted therapies?! 🧠 Trying to add POTS to "autonomic disorders," most of which are RARE by definition -- it creates a huge shortage of physicians who specialize in autonomic disorders ➡️ You want many doctors to diagnose and treat it, not a few, to increase and diversify therapeutic options. 🧠 Excluding POTS from neurologic education: this is a major mistake because the autonomic NERVOUS system is involved ➡️ When most neurologists are not well-versed in diagnosing and treating POTS, patients lose: neurology is not only about migraine or neuropathy! ❓ How to fix this??? Here is MY take on HOW: 🧠 Refocus POTS and dysautonomia on one mechanism instead of "it's everything" ➡️ Consider "neuroimmune" angle and try existing therapies that we have for other neuroimmune conditions (neurologic Sjogren's, lupus, MS) 🧠 Make tilt table tests, QSARTs and skin biopsies accessible and affordable for every community practice/hospital/clinic ➡️ Better diagnostic capabilities and precision diagnosis 🧠 Embrace POTS/dysautonomia as part of neurology residency curriculum - not just autonomic fellowship! ➡️ All neurologists would be required to diagnose and treat POTS in the same way that all neurologists are required to be able to diagnose and treat Parkinson's, diabetic neuropathy, migraine, etc. 🧠 Fund POTS research led by researchers with diverse and multidisciplinary backgrounds ➡️ When research money is going only to the few scientists and academic centers, you lose diversity of ideas and experiences, resulting in "more of the same" research studies. 🧠 Engage with Pharma more and better! ➡️ Learn from our headache medicine colleagues and what they have achieved in partnership with Pharma. Migraine and other headaches have no biomarkers and negative MRI of the brain, but there are over 30 FDA-approved medications and devices for treatment of migraine!

@femalelongevity How does one improve HRV?

Heart rate variability reflects autonomic balance and recovery capacity. Training intensity should be adjusted based on recovery, not just schedule.

@DrJesseMorse This is extremely helpful, I appreciate your sharing your expertise and breaking this down for us. How soon can we expect these treatments to be incorporated by main stream medicine and insurance? And in the meantime, what is a reasonable cost for them?

Here’s a deep dive into stem cells:

@femalelongevity I love your lists with the budget swaps! Thank you

I am Kayla Barnes-Lentz, the most publicly measured female. Follow me @femalelongevity for more longevity content.

Here's exactly what I eat in a day for health, longevity, and hormone optimization, plus budget swaps for everything: (THREAD):

@DrJesseMorse Are there options for people who don’t have professional athlete level funds to get these treatments? I asked my orthopedic doctor about PRP and they offer it for just over $1K per injection and I’m told it usually takes more than 1. Insurance won’t cover it, of course.

I entered the world of non-traditional back in 2020. Going full time into PRP, stem cells, peptides etc I have experienced how amazing the outcomes have been and unfortunately there isn’t a $50 million study confirming what I see everyday. My goal is to help patients the best and safest way I can. I just choose to do it in a different manner. Traditional medicine uses bandaids (cortisone), sometimes gets a little crazy (PRP) and then usually recommends surgery. I live in a different world. I get patients who don’t want the traditional approach. Most have had it and it failed. Or they don’t want surgery. IMO money should not be a rate-limiting factor for care. You think a professional athlete is going to ‘settle’ for PRP, which they’ve likely had access to for over 10 years when they can have something significantly stronger, less pain, faster recovery and the only difference is something they have a lot of (money). It’s an easy decision. They don’t care ‘what do the studies show?’ They care, does it work? Is it safe? Can I return faster to the field/court without having surgery? They only come to me if they were referred by another pro or their trainer/PT (who has other pros treated by me). They wouldn’t be referred if what I did didn’t work, especially if they spent a ton of money. The fact that they reach out means the person referring them believes in what I do and that it obviously worked. The majority of my patients are referred by my current patients.

Useful Victorian phrases for saying no to things. #TuesdayMotivation

@saylordocs Health

Real Luxuries in Life 1. Living 10 minutes from work 2. Living 5 minutes from the gym 3. Having quiet neighbors 4. Having money left at the end of the month and investing it 5. Peace at home 6. Drinking coffee without rushing 7. Sleeping with a clear conscience 8. Laughing with ....Show more

@RogerSeheult We wrote a paper on what not to say to patients with complex chronic illness. mdpi.com/1660-4601/22/2…

🧠 Love that list by Dr. @adamcifu. Here is my "Please do not do that research" list related to #Dysautonomia: 🗒️ 1. Please no studies on exercise and rehab programs in patients with #POTS, #MECFS or #LongCOVID. We get it... exercise is good for you and helps a good subset of patients, but self-selection and other biases in these studies preclude sweeping generalizations. Some patients cannot exercise, period. 2. Please no studies on psychological correlates, personality traits, anxiety, depression or childhood trauma in patients with #Dysautonomia, #MECFS and #LongCOVID. If you don't have at least one control group consisting of patients with MS or lupus, then your findings are useless. 3. Don't waste your time to study psychotherapy in patients with #POTS, #MECFS and #LongCOVID. It'll only work on patients with significant anxiety, poor coping mechanisms and inadequate social support. It won't work for the underlying pathophysiology of these disorders. 4. We get it: salt and compression are good for you if you have #Dysautonomia so we can stop doing these studies, except one.... is long-term increased salt intake associated with a higher risk of autoimmune disorders in patients with #Dysautonomia? We don't have this study and need one to estimate the risk in a population already prone to autoimmune disorders. 5. I really could care less if breathwork, meditation, music therapy or acupuncture are beneficial in patients with #POTS, #MECFS or #LongCOVID. Those things are beneficial for many stressed and overworked individuals, regardless of health or disease. Waste of time and money.... 6. Demographics, phenotypes, loss of smell and taste and other such things that have been studied ad nauseam in #LongCOVID do not need to be repeated in any cohorts from any country. Enough is enough. 7. As an editor and reviewer of many studies on POTS, some comparisons among groups are unnecessary and useless: I don't want to see outcome comparisons between POTS and VVS vs. POTS alone or POTS and EDS vs. POTS alone groups. The more disorders one has, the worse. We know! 8. No offense to my basic science colleagues: love and appreciate your work, but honestly, if you find that muscle sympathetic nerve activity in patients with POTS is higher than in healthy controls, thank you, but it helps nothing and no one. 9. Subjective vs. objective mismatch in patients with POTS/dysautonomia or Long COVID: don't want to hear about it. The autonomic function tests were not designed to assess patients with common autonomic disorders so yes, they will look amazing on the autonomic function tests, scoring 0-1 on CASS score, but they will be very sick and debilitated regardless, and no, it's not because they have anxiety, depression or deconditioning. 10. Finally... when you talk about VO2max as a marker of deconditioning, you're talking about research from decades ago. Reduced VO2max is not caused only by deconditioning: in our patients, it's most likely from mitochondrial and endothelial dysfunction, decreased organ perfusion and cellular metabolism problems. Thank you for reading my list! Please do sensible, logical and clinically relevant research! 👩‍🔬🔬🧬

🚨 Hot off the press: my new paper that moves this field forward 🚀 and changes the narrative on what #POTS, #MECFS and #LongCOVID are... Neuroimmune Disorders! 🧠 The brain and the autonomic nervous system are involved in the immune system regulation. 🧠 There is evidence of autoimmunity, immune dysregulation, cerebral hypoperfusion, neuroinflammation and other mechanisms in all three disorders. 🧠 #Neuroimmunology is a field that should embrace these disorders: #MultipleSclerosis, the staple of neuroimmunology, used to be called hysterical paralysis before CT and MRI were invented. We're at the same crossroads with these disorders. ❌ These disorders are not "mysterious", "anxiety", "deconditioning," "functional neurologic" etc. etc. ‼️ Classifying these disorders as neuroimmune and including them as part of neuroimmunology training is critical. 🛌 #PatientCare and lives of millions of people living with these disabling conditions are at stake! Thanks to my esteemed colleagues and co-authors, Dr. @TaylorDoherty8, immunologist from UC San Diego and Dr. Lawrence Steinman, neuroimmunologist from @StanfordMed, for their support! Read open-access paper here: 👇 dovepress.com/postural-ortho…

@NeurologistMom Thank you for this. I have two chronically ill daughters and relate deeply. I have followed you for a long time, you are an inspiration for me! I think of you and your daughter often and send prayers and positive thoughts for her recovery.

High-Class Social Intelligence: 1. Remembering names 2. Introducing people properly 3. Giving credit publicly 4. Correcting privately 5. Leaving conversations gracefully 6. Making others feel at ease 7. Asking thoughtful questions 8. Respecting boundaries 9. Thank-you notes that mean something 10. Never embarrassing others

@EricTopol Finally some good news today!

A dark chocolate constituent—theobromine—is linked to slower aging by DNA methylation (GrimAge) and telomere length in 2 cohorts. Published today at Aging but not yet on their website; preprint link: biorxiv.org/content/10.110…

Time and time again I see a lot of misconceptions about #POTS and #dysautonomia among physicians of all specialties. I'll repeat as many times as necessary: ‼️ POTS is not a psychiatric or psychological disorder ‼️ POTS is not a functional neurologic disorder or hysteria ‼️ POTS is not the same as anxiety or panic attacks ‼️ POTS is not due to past trauma or childhood adverse experience ‼️ POTS is not caused by deconditioning or laziness: elite athletes can develop POTS. ‼️ POTS is not the latest fad diagnosis: you see more of it because of #COVID, which can cause POTS as part of #LongCOVID. ‼️ POTS patients are no more difficult or whiny or anxious than any other patients with complex, disabling and multisystemic conditions. ‼️ Women with multiple sclerosis used to be labeled as hysterical, anxious and having past trauma: nobody says that about MS anymore so... use the same logic in POTS. #BrainHealth #MedTwitter #NeuroTwitter frontiersin.org/journals/neuro…