Lucia Natarelli

Today "a milestone in the evolution of personalized therapies for rare & ultra-rare inborn errors of metabolism" —the 1st human to undergo custom genome editing —outgrowth of decades of NIH funded research nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… @NEJM nytimes.com/2025/05/15/hea…

Red blood cells drive endothelial dysfunction in #diabetes! Read our article in @jclinicalinvest where we discuss the recent findings from the #PernowLab: jci.org/articles/view/… @CTECresearch #SarahCostantino @shafeeq_moham @GoricaEra

How much do you know about the longest-living Nobel Prize laureate ever? Learn more about medicine laureate Rita Levi-Montalcini who discovered nerve growth factor and was 103 years old when she passed away in 2012. #NobelPrize

#Heterochromatin #Mechanobiolgy Pulsatile #LaminarShearStress induces a sustained ⏫SUV39H1 (histone methyltransferase) & H3K9me3 enrichment on gene promoters of inflammatory genes (E-selectin VCAM1) in #EndothelialCells In contrast, #OscillatoryShearStress only causes a transient (1 h)⏫SUV39H1 & H3K9me3 SUV39H1 physically interacts with Emerin➡️nuclear peripheral enrichment of H3K9me3 & genomic loci of SELE & VCAM1 siRNA knockdown of Emerin⏬EC F-actin, SUV39H1, H3K9me3; ⏫VCAM1 E-selectin likely⏬mechanotransduction into nuclei any impact on alignment to flow?😁 @ucsdbe @PNASNews 2025 pnas.org/doi/10.1073/pn…

Science & fun! Exiting moments at the @EASCongress where also the #ipek Institute from @LMU_Muenchen was here represented by an amazing woman’s team!

🔈Excellent presentations are being delivered at the Workshop on Inflammatory Mechanisms in Atherosclerosis! #EASCongress2025 @society_eas

Super proud of my postdoc Zahra that made her first talk within the SaaG EAS session!!! #EASCongress2025 @society_eas the first of many other amazing moments !!! 😊

Finally here!!! A new exciting experience will start at the #eascongress2025 @EASCongress starting with an amazing landscape of Glasgow!

#ncRNAs #disease

The new Topic "Non-Coding RNAs as Regulators of Cellular Function and Disease" mdpi.com/si/234982 #mdpicells via @Cells_MDPI is open and ready for submissions !

Excited to invite you to contribute at our newly launched Research Topic on Frontiers in Immunology: "Role of Genotoxic Stressors and Survival / Metabolic Pathways in Inflammatory Activation and Cell Recruitment in Cardiovascular Diseases". lnkd.in/dzRY3RR

Congratulations to Broad associate member Gary Ruvkun and Victor Ambros of @UMassChan for receiving the 2024 @NobelPrize in Physiology or Medicine for the discovery of microRNA! #NobelPrize

#avaaz #indigenous #biodiversity #HumanRights

Indigenous Peoples protect the world's forests and precious biodiversity, but they cannot continue to do so if their lives and lands are continually put at risk. Join indigenous leaders demanding land rights here: secure.avaaz.org/campaign/it/co…

7 years ago, I met a junior fellow named @JD_Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (@ajaylabade31, @carolinecomenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

An exciting advance in Type 1 diabetes First person to receive her own stem cells, reprogrammed with transcription factors, to reverse it! @CellCellPress sciencedirect.com/science/articl… @Nature nature.com/articles/d4158…

Our paper defining how distinct DSB repair mechanisms re-assemble shattered chromosomes from micronuclei is now published! @Emily_Qing identified c-NHEJ as the major pathway and monitored the kinetics of repair and DNA rearrangements across the cell cycle. nature.com/articles/s4146…

My continued biological education Histone degradation by the #Proteasome regulates chromatin & cellular plasticity How long-lived Histones get degraded within 1 h upon dissociated with Chromatin? -> Proteasome in nuclei, Autophagy in cytosol When?-> DNA damage, Transcription, Tumor, Neuronal plasticity, Spermatogenesis 1/ Yifat Merbl lab @FEBS_Letters 2021 febs.onlinelibrary.wiley.com/doi/10.1111/fe…

Two papers in @Nature present a new genome editing technique that enables the insertion, inversion and deletion of long DNA sequences at user-specified genome positions. The approach may provide an easier method of genome editing. go.nature.com/3RGkI8M go.nature.com/3RHBvIs