Max Fottner

Peptide passports: Programmable import fuels novel protein building blocks dlvr.it/TPv3X7

New paper today in @ScienceMagazine shows Nudix hydrolase 5 protein binds adenosine, making some people sensitive to some chemo drugs. Maybe it binds NAD too, and this could desensitize patients to the toxicity science.org/doi/10.1126/sc…

Nature research paper: Hijacking a bacterial ABC transporter for genetic code expansion go.nature.com/3J2iTSE

Happy that this is finally online! Genetic code expansion approaches to decipher the ubiquitin code @ACSChemRev Many congratulations to Vera, Max and Marco! @VeraWanka @MaxFottner @MarkoCigler 🥂🎉🥳 pubs.acs.org/doi/10.1021/ac…

Thank you @GCEcenter @klang @AChemSynBio for the opportunity to share our work and hear what's happening with genetic code expansion at #GCE2024. And what a finish to the evening! 😎

@SatpalVirdee @GCEcenter @KLang @AChemSynBio You are as precise as your Ub probes when it comes to darts unfortunately (but could still improve on tagging @klanglab) 🫣 That one still haunts me 🎯 Officially requesting a Revanche 😬

Proud to see our 'detective story' on uncovering the MoA of Orpinolide published in its final form in @nchembio! Immensely grateful to @georg_e_winter, the Waldmann lab @mpimoph and @laraialab for being part of this fantastic collaboration!

I'm happy to share our News & Views article featured in @NatureChemistry, highlighting the excellent work on site-specific incorporation of glutarylated and succinylated lysine residues into multidomain proteins via genetic code expansion by @klanglab! nature.com/articles/s4155…

Check out our new paper @NatureChemistry where we use microfluidics to identify a mini enzyme from a de novo designed library giving a plausible scenario for emergence of enzymatic function at #OriginOfLife by #DirectedEvolution! nature.com/articles/s4155…

Very excited to co-organize GCE2024 with @AChemSynBio and @Mehl_lab at @GCEcenter! Come to Corvallis, Oregon to hear about the newest in genetic code expansion! We have a stellar speaker lineup from academia and industry!👇 Retweet and register! gceconferences.org

Biocatalysts make chemical industry more sustainable but engineering enzymes is too slow! Check out our preprint @hollfelderlab where we show how microfluidics & AI can help: We rapidly sequence-function profile an IRED in microdroplets and use AI to accelerate its engineering⚡️

Genetically encoding negatively charged lysine PTMs succinylation/glutarylation and studying their funcional roles! Great team effort by first authors @ML_Jokisch and @Maria_Weyh! Congrats @Maria_Weyh @ML_Jokisch @MaxFottner and Anh! 🥳🤩🙌👨‍🔬🧑‍🔬 @klanglab nature.com/articles/s4155…

Check out our latest preprint @hollfelderlab presenting a versatile cascade for enzyme screening in microfluidic droplets! We hope coupled assay like this will make microfluidics more accessible reducing cost and speeding up sustainable biocatalyst discovery timelines 🌱⏰

We have a new doctor in the @klanglab! Well done to Kristina - Dr. Krauskopf - who successfully defended her thesis!🎓🥳👏 Many thanks to @SieberLab and Hubert Gasteiger for being on the committee at TUM! Very sorry for only being present via Zoom and missing the party fun 🤒🦠🙄

Amazing virtual talk by @klanglab at #ESBOC56 @ESBOC_Gregynog. She talked about her group's work on expanding the functions of proteins with non-canonical amino acids. Great applications in bioconjugations, crosslinking and defined ubiquitin conjugates. nature.com/articles/s4146…

I am looking for a #Postdoc! Do you have #molecular_biology experience and are excited about developing top edge #drug_discovery modalities in a young team pomplunlab.com/open-positions/? Join us @LACDR @LeidenScience Please RT! nature.com/naturecareers/…

@ERC_Research funded #postdoc position in my group We are looking for a molecular biologist excited to help developing synthetic tools that can control gene transcription. @UniLeiden @LACDR @LeidenScience Please RT!!! And apply :-) universiteitleiden.nl/en/vacancies/2…

Check out our new paper for site-specific labeling proteins and building defined Ub/Ubl-protein conjugates using a plant Asp-endopeptidase. Great effort by @MaxFottner @jhmgrtnr @MaxGantz_ @RaMue1304 and @NkTimon! Congratulations to all!👩‍🔬👨‍🔬🤩🙌🥳

Site-Specific Protein Labeling & Generation of Defined Ubiquitin-Protein Conjugates Using an Asparaginyl Endopeptidase @ETH_DCHAB @ETH_en @klanglab @TU_Muenchen @MaxFottner #SiteSpecific #ProteinLabelling #Ubiquitin #Conjugates #Asparaginyl #Endopeptidase pubs.acs.org/doi/10.1021/ja…

Sometimes we must create artificial things to understand nature. Kathrin Lang @klanglab, new professor of #ChemicalBiology #LOC, develops special tools and enables deep insights into complex biological systems. Learn more on June 1 #inaugurallecture & on chab.ethz.ch/en/news-and-ev…