Maximilian Stötzel

How do embryos and ESCs safeguard pluripotency throughout a state of dormancy? A great collaborative effort of the @bulutkarslioglu -lab & the @MPI_MolGen involving @helenekretzmer @AbhiSampKumar @_taktas_ @VvdWeijden & many more. nature.com/articles/s4159…

@RCarhartHarris Very enjoyable read! Thanks for sharing.

A thoughtful new Substack series by one of our lab members: Decomposing Consciousness: Sentia, Sentience, Sapience. I appreciate the differentiation between sentience and 'sapience'—terms that echo phenomenal vs access consciousness... substack.com/home/post/p-16…

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios. embopress.org/doi/full/10.10…

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @NatureCellBio

📢 Preprint! Does the environment of a father before conception influence offspring? Even more, how do paternal genetics & age interact with exposures to affect F1 outcome? We tested this systematically, with intriguing findings & some cautionary tales biorxiv.org/content/10.110…

What a cool surprise on a Friday afternoon - our story on the cover of @NatureSMB. @bulutkarslioglu @MPI_MolGen

@MatthewKraushar @Tagesspiegel @MPI_MolGen Way to go Matt!

immensely grateful to the @Tagesspiegel Top 100 Minds in Science for this honor to the Kraushar Lab @MPI_MolGen, my mentors, colleagues, scientific community, friends and family near and far, and Berlin - thank you for becoming home ❤️

🎓Join the @bulutkarslioglu lab & our #IMPRS-BAC #gradschool to solve the key questions at the heart of cellular identity! As a PhD student, you will decipher the crosstalk between gene regulatory layers in #stemcells. #molecularbiology #development 👉 molgen.mpg.de/4644617/Bulut-…

I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? biorxiv.org/content/10.110… 1/

A nice video from Fabian Bachinger @VallierLab describing his research on large scale production of hepatocytes for cell based therapy. Thank you @wellcome_leap for supporting us the past 3 years #WellcomeLeap wellcomeleap.org/stories

Honored to receive the @ISSCR Merit Award! It's been a great meeting with inspiring conversations so far!

Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of @dhnisz, @VingronLab and Graf Lab published today in @NatureCellBio nature.com/articles/s4155…

The @dhnisz lab with the @VingronLab found chemical features in transcription factors (TFs) that encode submaximal transcriptional activity. The findings in @NatureCellBio hint ways to create optimized TFs that could be used for regenerative therapies. --> molgen.mpg.de/4726976

Humbled & excited that our paper on molecular recording of cellular decision in Trunk-Like Structures (TLS) got featured on the cover of @Dev_Cell! w/ B. Law, M. Chan @Princeton, Z. Smith @Yale, A. Meissner @MPI_MolGen & @jvveenvliet! Link to the paper: cell.com/developmental-…

1/2 The presence of extraembryonic cells in the developing gut has long puzzled scientists. @BatkiJulia (l) and @hetzel_s (r) (#Meissner lab) now gained new insight into the fate and molecular characteristics of these cells. @NatureCellBio Read more: molgen.mpg.de/4717564/

@_YiBei Congrats!

Great panel discussion on the future of Berlin science with Georg Duda @berlinnovation, @maxplanckpress Vice President @AsifaAkhtar1, Christian Rommel @BayerPharma, and MPIMG Director Alexander Meissner at our #MPIMG60years celebration!

@_taktas_ Thanks @_taktas_. I feel very honored!

Congratulations @Maxistoe et al. When Maxi started working on this project, he wanted to determine RNA targets of TETs and we offered our help. I have never seen someone master a technique so quickly and execute all the experiments in such a short time. Every lab needs a Maxi 😉

8/8 In summary, this work provides a molecular basis of how pluripotency is protected through a state of dormancy. The bookmarking hypothesis we put forward, provides an intriguing explanation of how cells remain dormant but yet maintain their identity once reactivated.

7/8 Using zygotic knockouts, ex-vivo and in-vivo models of diapause we supported the finding that in-vivo dormancy/diapause depends on TET activity. Augmentation of TETs via its known cofactors aKG and VitC increased early survival of blastocysts ex-vivo.

6/8 A combination of histone mod. CUT&Tag and functional readouts using SSEA-1 revealed a TET-dep. bookmarking of active enhancers and L1Mds that is unique within the chromatin landscape. Indicating a preferential react. upon reentering the proliferative phase after dormancy.

5/8 Using TF motif enrichment and TF footprinting we unraveled a TF network that potentially safeguards the pluripotent state. However, not via an immediate effect on transcription. But potentially via bookmarking the dormant genome. I.e. TFE3 accumulation at dormancy targets.