Wei Zhang

One of my major postdoc work paper out: Machine learning-based identification of general transcriptional predictors for plant disease nph.onlinelibrary.wiley.com/share/QNHDD6WZ…

To make Evo 2 more accessible, we're releasing Evo 2 20B, a checkpoint that achieves 40B-level performance on a single H100, as a drop-in replacement. This came out of model surgery with @danielchang2002, and we are excited to see people build on it! github.com/ArcInstitute/e…

Read the full paper: nature.com/articles/s4158…

Evo 2 is out in Nature today, showing that genome language models can predict and design across the full complexity of life, from phages to eukaryotes. A few surprises from the project, including how ignoring trillions of nucleotides was key to getting a good model. 🧵

I'm happy to share that since January, I have started my lab at @HelmholtzMunich @CompHealthMuc & Hauner CCRC (LMU) 🎉 We aim to combine single-cell, long-reads, computational modeling, and functional genomics to understand RNA-driven regulation in pediatric diseases.

New online! The AlphaGenome deep learning model predicts effects of non-coding variants dlvr.it/TR786Z

📢 Applications are open! This meeting brings together scientists using data-driven AI to analyze + model neural circuits and uncover how the brain performs complex computations. 🍽️ Meals + lodging covered Apply by May 28 ➡️ janelia.news/NAI26 @hhmi_science @HHMIJanelia

📢 We're searching for talented researchers/engineers to join us in building next-generation of open-source AI-ready datasets and models for microscopy image analysis. We're hiring four positions at Janelia Research Campus as part of the AI@HHMI initiative. Please share broadly with your network & with anyone who might be interested! @HHMIJanelia @HHMIJanelia ai.hhmi.org

Applications are open for Broad’s 2026 Media Boot Camp! Science/health reporters and editors: Join us in Cambridge (April 30–May 1) for a deep dive into emerging stories in biomedicine. Hotel & meals provided. Applications due March 20. Learn more here: broad.io/mediabootcamp

ENCODE’s registry of regulatory elements now includes 2.37M human and 967K mouse cCREs. Integrated annotations can help reveal how genetic variation shapes traits and gene function. nature.com/articles/s4158…

Excited to share VIPerturb-seq! New tech from my lab which aims to improve the cost, data quality, and efficiency of single-cell CRISPR screens so that they are accessible to any lab - even at genome-wide scale Preprint and 🧵 (1/): biorxiv.org/content/10.648…

Interested in 3' UTR changes in scRNA-seq? Check out our: * CPA-Perturb-seq paper * UCSC Perturb-seq tracks (see who regulates your favorite 3’ UTR!) * Seurat extension for polyA site analysis (PASTA) * Deep neural perturbation network (APARENT-Perturb) cell.com/cell/fulltext/…

My lab at the University of California, Davis is hiring a Junior Specialist! Apply by February 23. JPF07490:  Junior Specialist: Vascular Biology – Beleford Lab For more information and to apply: recruit.ucdavis.edu/JPF07490

🧬 We're hiring a postdoc! Come chart somatic evolution with us using cutting-edge long-read & single-cell tech 🔬 Computational bio background + love for complex cancer genomics = perfect fit 📍 Leuven, Belgium 📧 jobs.vib.be/j/129915/ #postdoc #genomics #hiring

[Postdoc Opportunity] Interested in research at the intersection of AI, regulatory genomics, and plant biology? Ware Lab and Koo Lab at CSHL are seeking a highly motivated postdoc fellow to pioneer this space! - Fully funded: Must be US citizens! - DM or email me CV Please RT!

1/13 Excited to share our (@anna_spiro @ChikinaLab @sara_mostafavi) latest preprint! 🧬💻 Personal Genome Prediction isn't just a downstream task—it’s the ultimate end-to-end benchmark for Variant Effect Prediction. We put the new SOTA AlphaGenome to the test and uncovered a striking "Modality Gap" between gene expression and chromatin accessibility. 📄 Link: biorxiv.org/content/10.648… 🧵👇

The next round of FutureHouse Postdoctoral Fellowships is due next week! Apply our AI tools to specific problems in biology and biochemistry, in collaboration with world-leading academic labs: --$125,000 annual stipend. --Access to all tools developed by FutureHouse and Edison Scientific at scale, including Kosmos and several as-of-yet unreleased agents, with under-the-hood access to them to specialize them for your workflows. --Receive dedicated software engineering support. --1 year with possible 1 year extension. Even more exceptional co-advisors than last year. Deadline for applications is February 13th, 2026. Link in next post.

My lab at MSKCC in New York is hiring for two positions. Join us at the frontier of functional genomics, studying fibroblast state transitions, combinatorial genetics, and ECM in disease. Please share with anyone who might be a good fit! (Mustache not required.)

Assistant/Associate/Full Professor of Surgery Genome Editing Delivery Specialist - San Francisco - University of California, San Francisco - jobs.sciencecareers.org/job/676994/ass… #sciencejobs

🚨 Now Open: @ParseBio Single Cell Grant (ANZ) This grant supports #cancer & complex biology projects and removes the usual cost barrier. Sequencing covered by Decode Science & @SA_genomics. Apply now: decodescience.com.au/seminar/parse-… #SingleCell #Genomics

🚀 Interested in a postdoc in computational biology & AI for neuroscience? The NOMIS Synergy Fellowship offers a great opportunity to develop such a position in my lab within the interdisciplinary Synergy excellence cluster. 🔗 synergy-munich.de/news-events/op…