Mounjaro Warlord

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Mounjaro Warlord@MounjaroNotes·3h

@MarcusPeptides High protein and resistance training to preserve lean mass part, agreed. Generalized tesamorelin use part, disagree. That is not a standard conclusion. With due respects, that is n=1 wrapped in peptide marketing.

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Marcus DeLuca@MarcusPeptides·8h

@MounjaroNotes the data is reassuring but real world I see way more LBM loss than trials report. trials select for compliant users who eat protein + train. avg patient crashes to 800 cal/day and skips the gym. protocol education matters more than the molecule itself.

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Mounjaro Warlord@MounjaroNotes·1d

Do people lose more skeletal muscle on Mounjaro/GLP-1s than in non-GLP-1 weight loss? Not clearly. Current evidence suggests the composition of weight lost on tirzepatide is broadly similar to standard weight loss: mostly fat, with some lean tissue.

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Mounjaro Warlord@MounjaroNotes·2d

In a standard well run weight loss journey, a rough rule of thumb is - 70–85% fat 10–20% lean tissue 5–15% water/glycogen fluctuation Not a law of nature, but a useful practical frame.

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Mounjaro Warlord@MounjaroNotes·3d

What do people actually lose during weight loss? Mainly 3 things - 1. Fat mass 2. Skeletal muscle / other lean tissue 3. Water and glycogen Lean mass is not just muscle. It also includes water, organs, connective tissue, etc.

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Mounjaro Warlord@MounjaroNotes·4d

GLP1s help people lose weight. The harder question is what helps them keep it off after stopping. This duodenal resurfacing data is early, but if it holds up, it could be a serious answer to one of obesity medicine’s biggest unsolved problems. reuters.com/business/healt…

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Mounjaro Warlord@MounjaroNotes·5d

67 kg had been playing hide and seek for over a month. Finally 12.5 mg Mounjaro moved the needle.

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Mounjaro Warlord@MounjaroNotes·6d

Very early 12.5 mg signal, but hard to ignore. The day 12.5 mg started, fasting glucose began dropping fast. Calorie intake followed. Weight then started responding. Interesting week!

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Mounjaro Warlord@MounjaroNotes·6d

@DummyBe91015083 None. On the same note, Mounjaro in fact is known to dramatically reduce arthritis pains.

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Milton Keynes@DummyBe91015083·6d

@MounjaroNotes No joint pains?

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Mounjaro Warlord@MounjaroNotes·25 Nis

12.5 mg Mounjaro is clearly more potent. Foul burps are back, hunger is muted, and there is a literal "knot in the stomach" feeling that removes the any urge to eat. My intake had drifted up to 2000 calories, has now crashed back to 1400.

Titrated to 12.5 mg Mounjaro today. Current NovoRapid use is already tiny, 0-2 units for breakfasts and 2-3 units at lunch. The experiment now is simple. Can 12.5 mg push the remaining bolus insulin requirement to zero? The next 4 weeks of data will decide.

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Mounjaro Warlord@MounjaroNotes·24 Nis

The last year on Mounjaro has been so disciplined and ritual driven that I logged almost everything: every calorie, every minute walked, every mg/dL of glucose. I now have 360 days of metabolic data. A proper n=1 study. I do wonder if Lilly would be interested in it.

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Mounjaro Warlord@MounjaroNotes·23 Nis

The math behind my move to 12.5 mg My data suggests every 1 mg increase in mounjaro reduced novorapid use by 1.35 units/day. So 10 → 12.5 mg = +2.5 mg. 1.35 × 2.5 = 3.375 units/day. My current novorapid use is about that. Hence the titration.

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Mounjaro Warlord@MounjaroNotes·22 Nis

@muratkberber Temel sebep, 12,5 mg’ın kalan küçük NovoRapid dozlarını bırakmama yardım edip etmeyeceğini görmek. HbA1c zaten 5,4%, ama bazı öğünlerde hâlâ çok küçük bolus insülin kullanıyorum. Yani bu rastgele doz artırma değil, takip edilen bir titrasyon denemesi.

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MKB@muratkberber·22 Nis

@MounjaroNotes 12,5mg cıkmışsın neden

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Mounjaro Warlord@MounjaroNotes·22 Nis

Titrated to 12.5 mg Mounjaro today. Current NovoRapid use is already tiny, 0-2 units for breakfasts and 2-3 units at lunch. The experiment now is simple. Can 12.5 mg push the remaining bolus insulin requirement to zero? The next 4 weeks of data will decide.

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Mounjaro Warlord@MounjaroNotes·21 Nis

Retatrutide’s “biologic” fight is not pure scientific taxonomy. It is also market control, exclusivity, anti-compounding leverage, and future biosimilar economics. Pharma law is chemistry wrapped in strategy, in the year end reported as earnings per share.

Biologic classification of retatrutide changes the approval pathway, exclusivity rules, biosimilar pathway, and compounding eligibility. In plain English, it can make copycatting and compounding much harder.

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Mounjaro Warlord@MounjaroNotes·20 Nis

Biologic classification of retatrutide changes the approval pathway, exclusivity rules, biosimilar pathway, and compounding eligibility. In plain English, it can make copycatting and compounding much harder.

How many broad types of medicines does FDA approve? 1. Drugs - usually chemically defined products approved through the New Drug Application (NDA) pathway. 2. Biologics - complex biological/protein-type products approved through the Biologics License Application (BLA) pathway.

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Mounjaro Warlord@MounjaroNotes·19 Nis

How many broad types of medicines does FDA approve? 1. Drugs - usually chemically defined products approved through the New Drug Application (NDA) pathway. 2. Biologics - complex biological/protein-type products approved through the Biologics License Application (BLA) pathway.

Lilly is pushing retatrutide to be classified as a biologic, not just a “drug.” FDA disagreed, and Lilly challenged it. A court has now told FDA to reconsider part of its reasoning. But why does @EliLillyandCo want retatrutide treated as a biologic, unlike tirzepatide?

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Mounjaro Warlord@MounjaroNotes·18 Nis

Lilly is pushing retatrutide to be classified as a biologic, not just a “drug.” FDA disagreed, and Lilly challenged it. A court has now told FDA to reconsider part of its reasoning. But why does @EliLillyandCo want retatrutide treated as a biologic, unlike tirzepatide?

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Mounjaro Warlord@MounjaroNotes·17 Nis

@DummyBe91015083 They do. Just took one on this wed. In fact post the forceful wrench, i use a syringe to suck out the remaining and inject that too. I empty the kwikpen completely. Full value extortion.

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Milton Keynes@DummyBe91015083·17 Nis

@MounjaroNotes Are golden doses still working for you? The pens simply aren’t working for the manual wrench for the golden dose like it used to for me.

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Mounjaro Warlord@MounjaroNotes·17 Nis

In India Cipla’s Yurpeak tirzepatide pen has 2.4 mL = 4 doses, so each 10 mg dose costs 4,116 . Lilly’s India pen has 3 mL and if you retrieve the “golden dose,” effective cost per 10 mg dose is 3,547. So Lilly still works out cheaper per dose. (Cost is discounted price)

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