N Molecular Systems

Recent advances reveal architecture of energy transduction systems in pathogens. Heme transporter CydDC promotes assembly/maturation of cytochrome bd (target for development of novel therapeutics). Cover depicts CydDC/heme embedded in bacterial bioenergetic membrane milieu.

(1/3) Molecular defense systems: bacteria deploy motorized spindles to entangle & degrade viral DNA. Checkout this intriguing work!! Structure and mechanism of Zorya anti-phage defence system. Nature (2025) Image for: @NMITaylorLab Created by: N Molecular Systems | @Nth_step

(2/3) Molecular defense systems: bacteria deploy motorized spindles to entangle & degrade viral DNA. Checkout this intriguing work!! Structure and mechanism of Zorya anti-phage defence system. Nature (2025) Image for: @NMITaylorLab Created by: N Molecular Systems | @Nth_step

(3/3) Molecular defense systems: bacteria deploy motorized spindles to trap & degrade viral DNA. Checkout this intriguing work!! Structure and mechanism of the Zorya anti-phage defence system. Nature (2025) Image for: @NMITaylorLab Created by: N Molecular Systems | @Nth_step

Molecular mechanism of substrate recognition and cleavage by human γ-secretase ▼ Science science.org/doi/10.1126/sc…

"Dissecting the conformational complexity and mechanism of a bacterial heme transporter" | A passage for heme | Nature Chemical Biology, August 2023 Vol. 19 No. 8 Open Access pdf: nature.com/articles/s4158… EMD-14640 | 7ZDB, ... emdataresource.org/EMD-14640

HEME TRANSPORTER. Decades-old enigma in bioenergetic membrane biogenesis. Max Planck's @MPIbp @SafarianSchara et al resolved CydDC in 23+ states/conditions 2.7-3.9Å by cryoEM, probing heme structural dynamics via mutations, 20 MD simulations. Image (2021, version B): @Nth_step

Thank you to Max Planck @MPIbp and to Nature @nchembio for selecting the cover. It looks great in print! Congrats to all for the great work @MPIbp @ALIFE_VU @UGent @UniKent @MiChAeL_900922 @AhmadRezaMehdi1 @franziska_f1nke @sonjawelsch @ShepherdLabKent @HummerLab @SafarianSchara

@SafarianSchara @MiChAeL_900922 @franziska_f1nke @AhmadRezaMehdi1 @HummerLab Truly elegant work. "Dissecting the conformational complexity and mechanism of a bacterial heme transporter" | Nature Chemical Biology Open Access: nature.com/articles/s4158…

This one was special! Very proud of our work, despite the long journey and dealing with most hostile reviews ever received. Major credit to @MiChAeL_900922, @franziska_f1nke, @AhmadRezaMehdi1, and @HummerLab

Congratulations to Safarian lab at Max Planck @MPIbp !! It was a real pleasure working with you! @SafarianSchara @MiChAeL_900922 nature.com/nchembio/volum…

Congrats to @NogalesLab @Yildiz_Lab on insights into MAP7 & Kinesin-1 science.org/doi/10.1126/sc… A warm flashback to our formative model (vis-a-vis 2018 "Microtubules: From Atoms to Complex Systems", EMBL) in collab with Ori-McKenney lab. #MAPs #kinesin #microtubules #cellpolarity

Our collaboration on PYRD 310-helical element implicated in human disease & conserved in kinesin superfamily molecular motors, with McKenney/@ucdavisbiology @GennerichLab/@EinsteinMed Niwa/@TohokuUniPR #AccelerateResearch, please read advances.sciencemag.org/content/7/18/e… @KIF1A #KAND #KIF1A

Intriguing aspect of the work @A_Amunts is 20Å gap between exit / insertase, providing for additional factors and #proteinfolding milieu (which differs from bacteria that favor early compaction of TM helices). We visualize 32 AA of #MTATP6 here (red) in place of poly-Ala in 6zm5.

If a machine could talk to us, what would it say? #beautifulmachine #code #recursion #dance youtube.com/watch?v=w0WY0p…