Olga ROSSPOPOFF

I’m excited to share a new preprint from some of my work in the lab of @todd_macfarlan ! 😄 We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice

Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale! biorxiv.org/content/10.110… A 🧵about what it can do:

Find out how genome loci are anchored to the nucleolus! Exciting preprint @Trono_Lab shows that ZNF274 competes with CTCF to keep H3K9me3 silenced genome at the nucleolus periphery, fine-tuning cell-specific gene expression. preLight: @Silviacamoeira ⬇️ prelights.biologists.com/highlights/clu…

@CRougeulle @institut_curie Félicitations @CRougeulle !!!! 🥳

Quel honneur pour moi de prendre la direction de Centre de Recherche de l’@institut_curie

Le Dr Claire Rougeulle, @CRougeulle, est nommée directrice du Centre de recherche de l’@institut_curie. Sa nomination le 3 juillet 2024 par le Directoire de l'Institut Curie, marque le début d'un mandat de 5 ans. ➡️ curie.fr/actualite/inst…

Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development pubmed.ncbi.nlm.nih.gov/38834912/ Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix

Excited to share our effort to understand mechanisms underlying the potential for gastruloids self-organisation! #Gastruloids #InNumberWeTrust #EMT biorxiv.org/content/10.110… 1/11

Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence nature.com/articles/s4146…

How does the segmentation clock instruct cells to form a somite boundary? Read our new pre-print “Clock driven waves of Tbx6 expression prefigure somite boundaries”, by @Olivier_Venzin and colleagues, to find out. biorxiv.org/content/10.110… Summary thread below: 1/15

Check out our latest preprint: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development biorxiv.org/content/10.110…

@TwelveSharp Insense brainstorming 😊

Ten points for cool paper title cell.com/trends/genetic…

Check this out: #lncRNA genes may exert their function through distinct mechanisms in different species. Thanks @JeffOui94 @ORSPF @Huret_C and all for your efforts. Stimulating collaboration with @RuggGunnLab and @heard_lab academic.oup.com/nar/advance-ar…

@JeffOui94 Thank you @JeffOui94 @CRougeulle & all co-authors 🥳

I have to acknowledge the amazing dedication that @ORSPF showed to get this beautiful and thoroughly assembled research during her PhD. Having three reviewers unanimously praise her manuscript was quite fantastic and hopefully, just a good omen for great things to come. 3/

SO HAPPY that this paper is finally out. Congrats to all involved (especially @ORSPF, @CRougeulle) for this career changing endeavour! After several attempts, I'm delighted that this has found a welcoming home in @NAR_Open (🙏 review process) #lncRNA 1/ academic.oup.com/nar/advance-ar…

Express delivery from the @jbloom_lab arrived today! Thank you very much @khdcrawford for sharing your plasmids for #SARSCoV2 neutralization assays from your recent @biorxivpreprint with us - we really appreciate it! biorxiv.org/content/10.110… Let the pseudotyping begin...

Working from home has reached a whole new level! Steve Henikoff is superexcited running his experiments using the CUT&Tag@home setup (PC: Jorja Henikoff). If you want to set this up, here is the link to CUT&Tag@home protocol protocols.io/view/cut-amp-t…

1/3 We had this recent #bioRxiv preprint from @todd_macfarlan and @Trono_Lab at our first Zoom-JC: biorxiv.org/content/10.110…. Very interesting study! Highlights include: large-scale ChIP-seq analysis of young KRAB-ZFPs in mouse followed by megabase CRISPR-deletion of KZFP clusters.

Didier Trono, a professor at @EPFL_en ’s Laboratory of Virology and Genetics, answers some common questions about SARS CoV-2 and the disease it causes, #COVID19. bit.ly/2ULMQt1

Day 1 of remote working due to #coronavirus. Well done @EPFL_en for taking the right measures and sending everyone to work from home - I hope other institutions across Europe do the same! Let's all work together and do our part to #FlattenTheCurve of #COVID19