PathSpotters

Chronic necrotising aspergillosis is locally invasive is seen in patients with immunodeficiency or chronic lung disease. Aspergilloma is a fungus ball that develops in a pre-existing cavity in the lung parenchyma. Acute angled dichotomous branching hyphae found in necrotic tissue

Warthin-like papillary thyroid carcinoma. 🔬Papillae lined with oncocytic cells, with prominent lymphocytic infiltration of stalks. Tumor nuclei are enlarged, irregularly sized with grooves and occasional pseudo-inclusions. Background of lymphocytic thyroiditis.

DEDIFFERENTIATED CHONDROSARCOMA. NB: juxtaposition of lower grade chondrosarcoma with an undifferentiated spindle-pleomorphic cell neoplasm; brisk mitotic activity; necrosis.

REtweet Kikuchi-Fujimoto disease. Necrosis without neutrophils, increased plasmacytoid dendritic cells, CD123 positive

Nodular melanoma: large profusely bleeding “skin tag" present for 3 months in the intergluteal fold. Positive for S100, Melan A, and HMB 45.Classic features: dermal-invasive melanoma with lack of significant radial growth phase (i.e. junctional component)

Metastatic breast IDC with lobular growth pattern in the pleural cavity: Cytology showed abundant atypical cells with cannibalism. Cell blocks were positive for MOC31, GATA-3, GCFDP-15, and negative for mucicarmine, ER, PR, HER2.

Multifocal oncocytoma/oncocytosis of parotid. 🔹multiple nodules, some circumscribed and some not. 🔹some can be clear cell rich. 🔹p63 should show an incomplete outer layer around the nests. But wait…aren’t these supposed to be golden brown grossly? See final pic.