Polymnia Georgiou

Tomorrow #ACNP2026 starts! Don't miss our symposium on Mon afternoon 3-5PM in Poseidon III-IV: "How Brain Estrogen Levels, Receptors & Signaling Govern Behaviors Across Sexes: Genes, Circuits, Synapses" w/ @PolymniaG @NeuroHoke Tara LeGates & myself. Looking forward! @ACNPorg

@VannaZachariou Congrats Vanna, very well deserved!

Honored and excited to be part of this group of ASPET Fellows #ASPET

We finally managed to take a new lab photo, with almost everyone! Always grateful for this amazing team and all the energy they bring. 💪

@KirmizisLab Thank you Antoni and thanks for the contributions to the team!

Congratulations Poly!!

@AyaOsman @molpsychiatry @pzanos @BrianMathur1 @KirmizisLab @Michael_Patton1 Thanks a lot Aya!

@PolymniaG @molpsychiatry @pzanos @BrianMathur1 @KirmizisLab @Michael_Patton1 Congratulations Poly! 👏🏾

📢Hot off the press! Excited to share our new paper in @molpsychiatry on the role of ERβ in stress vulnerability. Thanks to all of the authors involved @pzanos @BrianMathur1 @KirmizisLab @Michael_Patton1 nature.com/articles/s4138… A thread🧵

@Pignatelli_Lab @BrianMathur1 @molpsychiatry @pzanos @KirmizisLab @Michael_Patton1 Thanks Marco!

@PolymniaG @BrianMathur1 @molpsychiatry @pzanos @KirmizisLab @Michael_Patton1 🥳👏🏻 congrats !

Calcium activity in ERβ BLA-NAc terminals during social interaction is reduced in orchiectomized, stressed mice, and stimulating this circuit rescues social behavior, demonstrating its causal role in stress susceptibility.

Chemogenetic inhibition of ERβ-expressing BLA-NAc pathway induced social deficits in intact mice following acute mild stress

Thrilled to share our latest research studying the role of HPA axis hormones in major depression and antidepressant effects of ketamine @cazaratejr @baki_kadriu @PeixiongYuan @JenessaJohnson sciencedirect.com/science/articl… #DepressionResearch #Ketamine #HPAaxis #MentalHealthScience

Penn's Department of Genetics has several new tenure-track assistant professor openings. Please help spread the word! apply.interfolio.com/147616

Check our new pre-print out: Network-Based Analysis Identifies Targetable Pathways in Comorbid Type II Diabetes and Neuropsychiatric Disorders biorxiv.org/content/10.110…

@NeuroEndoAWF Thanks Aaron!

@PolymniaG Woohoo! Congrats Poly and team!

📢 Exciting News! Our latest study on the link between major depressive disorder, substance-use disorders l, and premature aging has just been published! 1/n Read the full study here : nature.com/articles/s4159…

@ChristofidesCY Thanks a lot Costa!

@PolymniaG Congratulation!!!

Congrats team! @pzanos @NeuroPharmLab and X-less Anna Onisiforou

-Antidepressants activating the PI3K/Akt/mTOR pathway could accelerate aging, making them unsuitable for MDD patients with dementia. We also highlighted potential anti-aging treatments for MDD, including Deferoxamine, Resveratrol, Estradiol valerate, zinc acetate and genistein.