Marco Pignatelli

Why do individuals with late-stage cancer sometimes struggle with motivation and experience profound apathy? In this multi lab effort ⁦@KepecsLab⁩ ⁦@JanowitzTobias⁩ and my lab we are tackling this question 👇🏻 😊 science.org/doi/10.1126/sc…

@jonykipnis 🤣

My claim that all we do is just trying to find better ways to clear brain waste has finally paid off and I got invited (albeit last minute but exciting nevertheless) to a conference exactly on the topic. Yes! I’m coming 🤩 See y’all there. “We sincerely apologize for this last-minute invitation. As the conference is fast approaching, we are delighted to invite you to participate in the "International Conference on Recycling and Waste Management (ICRWM-2026)," Hybrid event, from July 23–24, 2026 in Vienna, Austria, at the venue - Rainers Hotel.” We are happy to inform you that your impressive work got our attention to brings this invitation, which aligns perfectly with our conference theme.

@FlyBottleEscape Congrats 🎉🥰

tenure time 🍾

@jonykipnis @DrJKhokhar @DuSiling 🥳

cell.com/issue/S0896-62… On the cover: In this issue of Neuron, Du et al. @DuSiling show that repeated microglial depletion enables peripheral monocytes from both the blood and skull bone marrow to infiltrate the brain and engraft as monocyte-derived macrophages with distinct identities. Inspired by a passage from the Zuo Zhuan (“The first beat of the drum rouses the soldiers’ spirits; the second weakens their resolve; by the third, they are exhausted”), the artwork depicts three rounds of microglial depletion gradually exhausting the endogenous microglial niche. The two advancing armies represent distinct peripheral sources of invading cells: one arriving from the blood, illustrated by the army bearing the red flag, and the other emerging from the skull bone marrow, portrayed as descending from the mountains. Artist credit: Ying Xu.

Big deal 🥰

@FlanBrain @katybraden 🎉congrats !

First Castro Lab paper, brought to you by the hard work of Dr. Kathryn Braden @katybraden In this manuscript we investigate the role of endogenous enkephalin or dorsal raphe nucleus. We find that it is incredibly important for buffering negative affect 😱 nature.com/articles/s4138…

@jonykipnis Very cool !

Very interesting work on brain waste clearance through different routes || Physiological brain clearance architecture revealed by neuronal protein tracing: Cell cell.com/cell/fulltext/…

This is pretty neat ! ☺️ Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity | Nature Communications nature.com/articles/s4146…

Today is a sad day. May your soul RIP. In Memory of Howard L. Fields - International Association for the Study of Pain (IASP) iasp-pain.org/publications/i…

A brain reward circuit inhibited by next-generation weight-loss drugs in mice | Nature nature.com/articles/s4158…

@jonykipnis Ah ! 😋

@Pignatelli_Lab Here is to make you really jealous 😉

Another amazing AINI (Italian neuroimmunology society) meeting! This time in Rome 🤩 And I got a very dear Diploma of a honorary speaker with invitation to future meetings 😉🥂

@DavidBarker_PhD 🎉🎉🎉

I don't post here nearly as much as I used to, but happy to report that I've just been promoted to Associate Professor with Tenure at Rutgers. It's been a long hill to climb...

Very nice ! ☺️

Happy Birthday #rome 2779 years and still going strong ❤️

@s_k_inoue 🎉💪🏼

I am honored to receive the Young Scientists’ Award from Japan’s Ministry of Education, Culture, Sports, Science and Technology. これまでのメンター・共同研究者の皆さまに心から感謝し、今後も面白い研究を追及して精進してまいります。mext.go.jp/b_menu/houdou/…

@KaganovskyNeuro @MarkPlitt @lisa_giocomo Super cool ! Congrats @KaganovskyNeuro !💪🏼🎉

Very excited to share the fruits of an epic collaboration with @MarkPlitt from @lisa_giocomo lab: doi.org/10.1016/j.neur…

🧵 We’re hiring a Staff Scientist at @NIH @NIAAAnews ! Ready to lead research that bridges the senses, the brain, and human health? Read on. 👇

Nice ! The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression | Molecular Psychiatry nature.com/articles/s4138…

Great opportunity ! 👇🏻 Staff Scientist | Office of Intramural Training & Education at the National Institutes of Health training.nih.gov/jobs/ss-032426/

A small polymerase ribozyme that can synthesize itself and its complementary strand | Science Molecular basis for the origin of life?! 😊 science.org/doi/10.1126/sc…